2000
Localization, allelic heterogeneity, and origins of the hemochromatosis gene
Raha-Chowdhury R, Gruen J. Localization, allelic heterogeneity, and origins of the hemochromatosis gene. 2000, 75-90. DOI: 10.1017/cbo9780511666476.008.Peer-Reviewed Original ResearchMajor histocompatibility complexHemochromatosis geneIron absorptionDisease of adultsHLA class IExcessive iron absorptionEnhanced iron absorptionCommon autosomal recessive disorderAutosomal recessive disorderNeonatal hemochromatosisOrgan damageChildhood onsetFifth decadeClinical heterogeneityHLAHemochromatosisIntroduction HemochromatosisIron accumulationHistocompatibility complexClass IRecessive disorderDiseaseDifferent diseasesVariables ageChromosomal translocations
1992
Physical and genetic mapping of the telomeric major histocompatibility complex region in man and relevance to the primary hemochromatosis gene (HFE)
Gruen J, Goei V, Summers K, Capossela A, Powell L, Halliday J, Zoghbi H, Shukla H, Weissman S. Physical and genetic mapping of the telomeric major histocompatibility complex region in man and relevance to the primary hemochromatosis gene (HFE). Genomics 1992, 14: 232-240. PMID: 1427838, DOI: 10.1016/s0888-7543(05)80211-3.Peer-Reviewed Original ResearchConceptsPhysical mapGenomic DNACell linesRadiation hybrid cell linesHigh-resolution physical mapLong-range physical mapGenetic mapping studiesHuman genomic DNAPulsed-field gel electrophoresisHybrid cell linesRestriction fragment banding patternsMajor histocompatibility complex regionGenetic mappingMajor histocompatibility complex (MHC) class I regionHuman genomeHLA-F geneBanding patternsClass I regionGenesDisequilibrium analysisGel electrophoresisMapping studiesDNAI regionClass I