Signal requirements for the generation of CD4+ and CD8+ T-cell responses to human allogeneic microvascular endothelium.
Pardi R, Bender J. Signal requirements for the generation of CD4+ and CD8+ T-cell responses to human allogeneic microvascular endothelium. Circulation Research 1991, 69: 1269-1279. PMID: 1934357, DOI: 10.1161/01.res.69.5.1269.Peer-Reviewed Original ResearchConceptsT cell precursorsEndothelial cellsInterleukin-2T cellsT lymphocytesMicrovascular endotheliumT cell-mediated immune responsesMajor T cell subsetsSpecific cytotoxic T lymphocytesMonocyte/macrophage seriesMHC class II determinantsCD3/T cell receptor complexIndividual cell subsetsGeneration of CD4Effector T cellsClass II determinantsT cell responsesT cell subsetsAdoptive transfer experimentsAllogeneic endothelial cellsClass I determinantsSelf-MHC moleculesCytotoxic T lymphocytesMonocytes/macrophagesT cell receptor complex