1999
Anchorage dependence of mitogen-induced G1 to S transition in primary T lymphocytes.
Geginat J, Bossi G, Bender J, Pardi R. Anchorage dependence of mitogen-induced G1 to S transition in primary T lymphocytes. The Journal Of Immunology 1999, 162: 5085-93. PMID: 10227977, DOI: 10.4049/jimmunol.162.9.5085.Peer-Reviewed Original ResearchMeSH KeywordsAntibodies, MonoclonalCalcium-Calmodulin-Dependent Protein KinasesCell AdhesionCell CycleCell Cycle ProteinsCell SizeCyclin-Dependent Kinase 4Cyclin-Dependent Kinase 6Cyclin-Dependent Kinase Inhibitor p27Cyclin-Dependent KinasesDown-RegulationEnzyme ActivationG1 PhaseGene Expression RegulationGenes, fosGenes, junHumansInterleukin-2InterphaseKineticsLymphocyte Function-Associated Antigen-1Microtubule-Associated ProteinsMitogensProtein Serine-Threonine KinasesProto-Oncogene ProteinsReceptors, Antigen, T-CellS PhaseT-LymphocytesTumor Suppressor ProteinsConceptsNormal T cellsT lymphocytesT cellsPrimary T lymphocytesRetinoblastoma protein inactivationCytokines IL-2Function-blocking mAbsIL-2ICAM-1Mitogen-activated protein kinase activationCyclin-dependent kinase inhibitor p27kipIntegrins actMitogenic responseMitogenic cytokinesGrowth factorLymphocytesCell cycle progressionTCR stimulationLate componentsProtein kinase activationLeukocyte integrinsAnchorage dependenceTCR triggeringCycle progressionCellular requirements
1989
Heterogeneous distribution and transmembrane signaling properties of lymphocyte function-associated antigen (LFA-1) in human lymphocyte subsets.
Pardi R, Bender J, Dettori C, Giannazza E, Engleman E. Heterogeneous distribution and transmembrane signaling properties of lymphocyte function-associated antigen (LFA-1) in human lymphocyte subsets. The Journal Of Immunology 1989, 143: 3157-66. PMID: 2553807, DOI: 10.4049/jimmunol.143.10.3157.Peer-Reviewed Original ResearchMeSH KeywordsAdultAntigens, DifferentiationCell AdhesionCell MembraneCross-Linking ReagentsEndothelium, VascularHumansHydrolysisInterphaseLymphocyte Function-Associated Antigen-1LymphocytesMembrane GlycoproteinsN-Acetylneuraminic AcidPhosphatidylinositolsReceptors, Leukocyte-AdhesionSialic AcidsSignal TransductionStructure-Activity RelationshipConceptsLymphocyte subsetsLFA-1Lymphocyte function-associated antigenDifferent lymphocyte subsetsHuman lymphocyte subsetsFunction-associated antigenAnti-beta subunit antibodiesCell surface densityPhosphoinositide hydrolysisSialic acid contentSubunit antibodiesVariable expressionIntegrin supergene familyLFA-1 alpha subunitNatural ligandCell bindingNeuraminidase digestionActivation eventsRelative increaseAlpha subunitSupergene familySubsetBeta subunit