2004
Vascular cell adhesion molecule-1-targeted detection of endothelial activation in human microvasculature
Sadeghi MM, Schechner JS, Krassilnikova S, Gharaei AA, Zhang J, Kirkiles-Smith N, Sinusas AJ, Zaret BL, Bender JR. Vascular cell adhesion molecule-1-targeted detection of endothelial activation in human microvasculature. Transplantation Proceedings 2004, 36: 1585-1591. PMID: 15251390, DOI: 10.1016/j.transproceed.2004.05.060.Peer-Reviewed Original ResearchConceptsChimeric human/mouse modelHuman/mouse modelHuman skin graftsEndothelial activationSkin graftsEndothelial cellsMouse modelIsotype-matched control antibodySCID/beige miceTumor necrosis factorEndothelial adhesion moleculesMurine VCAM-1Murine red blood cellsRed blood cellsHuman endothelial cellsControl antibodyInflammatory responseNecrosis factorBeige miceTc-99mVCAM-1Tissue vascularityMonoclonal antibodiesBlood cellsAdhesion molecules
2002
Endothelial cell seeding influences lesion development following arterial injury in the cholesterol-fed rabbit
Conte MS, VanMeter GA, Akst LM, Clemons T, Kashgarian M, Bender JR. Endothelial cell seeding influences lesion development following arterial injury in the cholesterol-fed rabbit. Cardiovascular Research 2002, 53: 502-511. PMID: 11827702, DOI: 10.1016/s0008-6363(01)00486-2.Peer-Reviewed Original ResearchConceptsFinal lumen areaEndothelial cellsEndothelial restorationNeointimal areaLumen areaAutologous venous endothelial cellsLarger neointimal areaPositive remodeling indexBalloon catheter injuryTime of injuryHigh-grade stenosisCholesterol-fed rabbitsCholesterol-supplemented dietVessel wall repairVenous endothelial cellsIntact endothelial monolayerCatheter injuryRemodeling indexArterial injuryBalloon angioplastyIliofemoral arteriesContralateral vesselLuminal diameterVascular remodelingGrade stenosis