2020
A potential association of an interferon gene signature with RBC alloimmunization in sickle cell disease
Madany E, Kadi N, Pandya S, Hendrickson J, Gibb D. A potential association of an interferon gene signature with RBC alloimmunization in sickle cell disease. The Journal Of Immunology 2020, 204: 145.18-145.18. DOI: 10.4049/jimmunol.204.supp.145.18.Peer-Reviewed Original ResearchSickle cell diseaseInterferon-stimulated genesRBC alloimmunizationMore alloantibodiesGene signatureSCD patientsCell diseaseFrequency of alloimmunizationChronic inflammatory stateInterferon gene signatureProduction of alloantibodiesMultiple interferon-stimulated genesType 1 interferonMyxovirus resistance protein 1Resistance protein 1Alloimmunization frequencyCompatible RBCsRBC transfusionInflammatory stateMxA expressionDisease populationTransfusion modelAlloimmunizationPatientsSiglec-1
2019
Increased Expression of Type 1 Interferon Stimulated Genes in Sickle Cell Disease and a Potential Association with RBC Alloimmunization
Madany E, Kadi N, Pandya S, Hendrickson J, Gibb D. Increased Expression of Type 1 Interferon Stimulated Genes in Sickle Cell Disease and a Potential Association with RBC Alloimmunization. Blood 2019, 134: 716. DOI: 10.1182/blood-2019-124899.Peer-Reviewed Original ResearchSickle cell diseaseFrequency of alloimmunizationSickle cell patientsInterferon Stimulated GenesSS patientsCell diseaseType 1 interferonMore alloantibodiesMxA levelsCell patientsSS diseaseRBC alloimmunizationSiglec-1Gene signatureElevated levelsNon-alloimmunized patientsInflammatory autoimmune diseaseChronic inflammatory stateProduction of alloantibodiesHemolytic transfusion reactionsIFN gene signatureExpression of MxAMann-Whitney U testMean fluorescence intensityMyxovirus resistance protein 1