Effects of genetic, epigenetic, and environmental factors on alloimmunization to transfused antigens: Current paradigms and future considerations
Zimring J, Stowell S, Johnsen J, Hendrickson J. Effects of genetic, epigenetic, and environmental factors on alloimmunization to transfused antigens: Current paradigms and future considerations. Transfusion Clinique Et Biologique 2012, 19: 125-131. PMID: 22682308, DOI: 10.1016/j.tracli.2012.03.002.Peer-Reviewed Original ResearchConceptsImmune systemLarge observational studiesMinority of recipientsHuman immune systemTransfused cellsContext of transfusionRed blood cellsTransfusion therapyObservational studyImmune responseAdditional antibodiesCoagulation factorsAlloimmunizationClinical barriersBlood cellsRecent mechanistic studiesRecipientsTransfusionPatientsPotential causesAntigenAntibodiesMicrobial pathogensCellsResponse