2023
Antibody-mediated antigen loss switches augmented immunity to antibody-mediated immunosuppression
Jajosky R, Patel K, Allen J, Zerra P, Chonat S, Ayona D, Maier C, Morais D, Wu S, Luckey C, Eisenbarth S, Roback J, Fasano R, Josephson C, Manis J, Chai L, Hendrickson J, Hudson K, Arthur C, Stowell S. Antibody-mediated antigen loss switches augmented immunity to antibody-mediated immunosuppression. Blood 2023, 142: 1082-1098. PMID: 37363865, PMCID: PMC10541552, DOI: 10.1182/blood.2022018591.Peer-Reviewed Original ResearchConceptsAntibody-mediated immunosuppressionRBC alloantigensImmune responseFetal red blood cell antigensTarget antigenRed blood cell antigensRh immune globulinMaternal immune responseBlood cell antigensInclusion of antibodiesRBC removalAnti-RhD antibodiesAbility of antibodiesImmune globulinAntibody responseHemolytic diseaseRBC clearanceCell antigensFetal RBCsAntibody characteristicsAlloantigensSimilar interventionsAntibodiesAntigenPolyclonal antibody preparation
2013
Storage-Induced Clearance Of RBCs Following Transfusion Occurs Independent Of RBC Age
Arthur C, Smith N, Zimring J, Hendrickson J, Stowell S. Storage-Induced Clearance Of RBCs Following Transfusion Occurs Independent Of RBC Age. Blood 2013, 122: 792. DOI: 10.1182/blood.v122.21.792.792.Peer-Reviewed Original ResearchOld RBCsPost transfusionPositive RBCsEnhanced clearanceRBC ageCytometric analysisPreferential clearanceCitrate phosphate dextrose adenineDays post transfusionPercent of RBCsRBC removalRed blood cell storageClearance of RBCsFlow cytometric analysisTransfused RBCsB6 miceDonor RBCsTransfusionSenescent markersRBC clearanceGradual clearanceClearance phaseRapid clearanceClearanceStored RBCs