2023
Antibody-mediated antigen loss switches augmented immunity to antibody-mediated immunosuppression
Jajosky R, Patel K, Allen J, Zerra P, Chonat S, Ayona D, Maier C, Morais D, Wu S, Luckey C, Eisenbarth S, Roback J, Fasano R, Josephson C, Manis J, Chai L, Hendrickson J, Hudson K, Arthur C, Stowell S. Antibody-mediated antigen loss switches augmented immunity to antibody-mediated immunosuppression. Blood 2023, 142: 1082-1098. PMID: 37363865, PMCID: PMC10541552, DOI: 10.1182/blood.2022018591.Peer-Reviewed Original ResearchConceptsAntibody-mediated immunosuppressionRBC alloantigensImmune responseFetal red blood cell antigensTarget antigenRed blood cell antigensRh immune globulinMaternal immune responseBlood cell antigensInclusion of antibodiesRBC removalAnti-RhD antibodiesAbility of antibodiesImmune globulinAntibody responseHemolytic diseaseRBC clearanceCell antigensFetal RBCsAntibody characteristicsAlloantigensSimilar interventionsAntibodiesAntigenPolyclonal antibody preparationEnhanced IgG immune response to COVID‐19 vaccination in patients with sickle cell disease
Nakahara H, Cheedarla N, Verkerke H, Cheedarla S, Wu S, Hendrickson J, Chang A, McLemore M, Rassi F, Roback J, Neish A, Fasano R, Stowell S. Enhanced IgG immune response to COVID‐19 vaccination in patients with sickle cell disease. British Journal Of Haematology 2023, 202: 937-941. PMID: 37287128, PMCID: PMC10751105, DOI: 10.1111/bjh.18899.Peer-Reviewed Original ResearchConceptsSickle cell diseaseCOVID-19 vaccinationAntibody responseCell diseaseSARS-CoV-2 vaccinationIgG immune responseSimilar antibody responsesOptimal vaccination strategyIgG titresIgG responsesVaccination strategiesImmune responseSCD controlsGeneral populationPatientsVaccinationDiseaseResponseCohortTitres
2022
Antibody-Mediated Antigen Loss Can Switch an Augmented Immune Response to Antibody-Mediated Immunosuppression
Jajosky R, Allen J, Zerra P, Maier C, Chonat S, Luckey C, Roback J, Fasano R, Josephson C, Manis J, Chai L, Hendrickson J, Hudson K, Arthur C, Stowell S. Antibody-Mediated Antigen Loss Can Switch an Augmented Immune Response to Antibody-Mediated Immunosuppression. Blood 2022, 140: 73-74. DOI: 10.1182/blood-2022-170081.Peer-Reviewed Original Research
2021
The lysophospholipid‐binding molecule CD1D is not required for the alloimmunization response to fresh or stored RBCs in mice despite RBC storage driving alterations in lysophospholipids
Medved J, Knott BM, Tarrah SN, Li AN, Shah N, Moscovich TC, Boscia AR, Salazar JE, Santhanakrishnan M, Hendrickson JE, Fu X, Zimring JC, Luckey CJ. The lysophospholipid‐binding molecule CD1D is not required for the alloimmunization response to fresh or stored RBCs in mice despite RBC storage driving alterations in lysophospholipids. Transfusion 2021, 61: 2169-2178. PMID: 34181769, PMCID: PMC8856511, DOI: 10.1111/trf.16554.Peer-Reviewed Original ResearchMeSH KeywordsAlarminsAnimalsAntibody SpecificityAntigens, CD1dBlood PreservationBlood TransfusionDuffy Blood-Group SystemErythrocytesFemaleImmunizationImmunoglobulin GImmunoglobulin MIsoantibodiesIsoantigensLysophospholipidsMaleMass SpectrometryMiceMice, Inbred StrainsMice, KnockoutMice, TransgenicMuramidaseOvalbuminReceptors, Cell SurfaceTransfusion ReactionConceptsCD1d-deficient miceCD1d deficiencyRBC alloimmunizationImmune activationNonclassical major histocompatibility complex class IWild-type control miceMajor histocompatibility complex class IHistocompatibility complex class IAdverse clinical consequencesSignificant adverse clinical consequencesLow baseline levelsRBC storageComplex class IHOD RBCsMolecule CD1dRBC transfusionWT miceControl miceImmune responseClinical consequencesMouse modelCD1dCD1d recognitionPolyclonal immunoglobulinsBaseline levels
2018
3 The Importance of CD4 Cells and CD40/CD40 Ligand Interactions in Humoral Immune Responses to Transfused KEL RBCs in Mice
Madrid D, Gibb D, Natarajan P, Santhanakrishnan M, Liu J, Hendrickson J. 3 The Importance of CD4 Cells and CD40/CD40 Ligand Interactions in Humoral Immune Responses to Transfused KEL RBCs in Mice. American Journal Of Clinical Pathology 2018, 149: s164-s164. DOI: 10.1093/ajcp/aqx149.372.Peer-Reviewed Original ResearchCD40/CD40 ligand interactionsCD40 ligand interactionsCD40/CD40L blockadeWild-type animalsRed blood cellsNonresponder animalsCD40L blockadeWeeks posttransfusionType animalsIgG antibodiesT cellsImmune responseMonoclonal antibodiesAbsence of CD4CD40 ligand blockadeHuman KEL glycoproteinFlow cytometric crossmatchHemolytic transfusion reactionsDurable immune responsesHumoral immune responseWild-type miceDevelopment of alloantibodiesT cell interactionsMurine red blood cellsAlloantibody responses
2017
Red blood cell alloimmunisation: induction of immunity and potential mitigation strategies
Hendrickson J. Red blood cell alloimmunisation: induction of immunity and potential mitigation strategies. ISBT Science Series 2017, 13: 105-111. DOI: 10.1111/voxs.12360.Peer-Reviewed Original ResearchAnimal modelsChronic inflammatory disease statesRBC unitsAntigen-specific toleranceT-cell markersInduction of immunityInflammatory disease statesHumoral immune responseHumoral immune responsivenessAlloantibody developmentRBC alloimmunisationDonor antigensDendritic cellsRBC alloantibodiesRBC transfusionTransfusion recipientsImmune responsivenessRBC exposureRisk factorsMurine studiesForeign antigensImmune responseCD 4Danger signalsImmune system
2015
Innate and adaptive immune responses to transfused alloantigens
Zimring J, Hudson K, Hendrickson J. Innate and adaptive immune responses to transfused alloantigens. Pathology 2015, 47: s41. DOI: 10.1097/01.pat.0000461433.20240.46.Peer-Reviewed Original ResearchInnate immune activationRed blood cellsImmune activationMurine modelToll-like receptor agonistsAdaptive immune responsesExposure of recipientsRBC alloantigensSubsequent transfusionsMultiple transfusionsRBC alloantibodiesRBC transfusionTLR agonistsReceptor agonistImmune responseMouse modelTransfusionHuman studiesInnate immunityAlloimmunisationAlloantigensBlood cellsSuch exposureRecipientsAgonistsInnate and adaptive immune responses to transfused alloantigens
Zimring J, Hudson K, Hendrickson J. Innate and adaptive immune responses to transfused alloantigens. Pathology 2015, 47: s34. DOI: 10.1097/01.pat.0000461421.80336.37.Peer-Reviewed Original ResearchInnate immune activationRed blood cellsImmune activationMurine modelToll-like receptor agonistsAdaptive immune responsesExposure of recipientsRBC alloantigensSubsequent transfusionsMultiple transfusionsRBC alloantibodiesRBC transfusionTLR agonistsReceptor agonistImmune responseMouse modelTransfusionHuman studiesInnate immunityAlloimmunisationAlloantigensBlood cellsSuch exposureRecipientsAgonists
2012
Effects of genetic, epigenetic, and environmental factors on alloimmunization to transfused antigens: Current paradigms and future considerations
Zimring J, Stowell S, Johnsen J, Hendrickson J. Effects of genetic, epigenetic, and environmental factors on alloimmunization to transfused antigens: Current paradigms and future considerations. Transfusion Clinique Et Biologique 2012, 19: 125-131. PMID: 22682308, DOI: 10.1016/j.tracli.2012.03.002.Peer-Reviewed Original ResearchConceptsImmune systemLarge observational studiesMinority of recipientsHuman immune systemTransfused cellsContext of transfusionRed blood cellsTransfusion therapyObservational studyImmune responseAdditional antibodiesCoagulation factorsAlloimmunizationClinical barriersBlood cellsRecent mechanistic studiesRecipientsTransfusionPatientsPotential causesAntigenAntibodiesMicrobial pathogensCellsResponse
2011
Central T Cell Tolerance and Peripheral B Cell Tolerance for An RBC Autoantigen Are Incomplete in Healthy Mice; Implications for AIHA Pathogenesis
Hudson K, Hendrickson J, Cadwell C, Iwakoshi N, Zimring J. Central T Cell Tolerance and Peripheral B Cell Tolerance for An RBC Autoantigen Are Incomplete in Healthy Mice; Implications for AIHA Pathogenesis. Blood 2011, 118: 693. DOI: 10.1182/blood.v118.21.693.693.Peer-Reviewed Original ResearchAutoimmune hemolytic anemiaT cell toleranceOVA/CFAB cell tolerancePathogenesis of AIHAReactive T cellsT cellsHOD antigenAdoptive transferPeripheral toleranceCell toleranceB cellsB6 miceHen egg lysozymeHOD RBCsReactive CD4Humoral toleranceF1 miceImmune responseAntigen expressionTransgenic miceWild-type B6 miceWild-type C57BL/6 micePeripheral B cell toleranceOT-II CD4
2006
Recipient Inflammation That Increases Alloimmunization Also Enhances Consumption of Transfused RBCs by Dendritic Cells.
Hendrickson J, Roback J, Hillyer C, Zimring J. Recipient Inflammation That Increases Alloimmunization Also Enhances Consumption of Transfused RBCs by Dendritic Cells. Blood 2006, 108: 23. DOI: 10.1182/blood.v108.11.23.23.Peer-Reviewed Original ResearchLiver dendritic cellsDendritic cellsT cellsRBC antigensRed blood cellsImmune responseSplenic macrophagesB cellsRBC consumptionCo-stimulatory molecule expressionBlood cellsRed blood cell antigensMajority of patientsC57BL/6 recipient micePresence of inflammationAbsence of inflammationRole of antigenLymph node macrophagesBlood cell antigensRBC alloimmunizationRecipient inflammationAlloantibody responsesLymph nodesRBC transfusionPotent APCs