2021
Altered type 1 interferon responses in alloimmunized and nonalloimmunized patients with sickle cell disease
Madany E, Lee J, Halprin C, Seo J, Baca N, Majlessipour F, Hendrickson JE, Pepkowitz SH, Hayes C, Klapper E, Gibb DR. Altered type 1 interferon responses in alloimmunized and nonalloimmunized patients with sickle cell disease. EJHaem 2021, 2: 700-710. PMID: 35128535, PMCID: PMC8813163, DOI: 10.1002/jha2.270.Peer-Reviewed Original ResearchPeripheral blood mononuclear cellsSickle cell diseaseCell diseaseRace-matched healthy controlsType 1 interferon responseFrequency of alloimmunizationNon-alloimmunized patientsBlood mononuclear cellsType 1 interferonExpression of ISGsGene scoreNonalloimmunized patientsRBC alloimmunizationPlasma cytokinesSCD patientsMononuclear cellsHealthy controlsHigh prevalenceBlood leukocytesAlloimmunizationViral immunityPatientsIFNISG expressionInterferon response
2020
Type I Interferon Gene Signature in Peripheral Blood Mononuclear Cells of Sickle Cell Disease Patients and a Connection to RBC Alloimmunization
Madany E, Lee J, Hendrickson J, Gibb D. Type I Interferon Gene Signature in Peripheral Blood Mononuclear Cells of Sickle Cell Disease Patients and a Connection to RBC Alloimmunization. Blood 2020, 136: 26-27. DOI: 10.1182/blood-2020-142935.Peer-Reviewed Original ResearchFrequency of alloimmunizationInterferon Stimulated GenesHigher IFN scoresInterferon gene signatureSS patientsSickle cell patientsIFN scoreSickle cell diseaseSS diseaseHealthy controlsGene signatureRBC alloimmunizationCell patientsCell diseaseType I interferon gene signaturePeripheral blood mononuclear cellsSickle cell disease patientsInflammatory autoimmune diseaseWhole bloodChronic inflammatory stateType 1 IFNBlood mononuclear cellsIFN gene signatureType 1 interferonMyxovirus resistance protein 1A potential association of an interferon gene signature with RBC alloimmunization in sickle cell disease
Madany E, Kadi N, Pandya S, Hendrickson J, Gibb D. A potential association of an interferon gene signature with RBC alloimmunization in sickle cell disease. The Journal Of Immunology 2020, 204: 145.18-145.18. DOI: 10.4049/jimmunol.204.supp.145.18.Peer-Reviewed Original ResearchSickle cell diseaseInterferon-stimulated genesRBC alloimmunizationMore alloantibodiesGene signatureSCD patientsCell diseaseFrequency of alloimmunizationChronic inflammatory stateInterferon gene signatureProduction of alloantibodiesMultiple interferon-stimulated genesType 1 interferonMyxovirus resistance protein 1Resistance protein 1Alloimmunization frequencyCompatible RBCsRBC transfusionInflammatory stateMxA expressionDisease populationTransfusion modelAlloimmunizationPatientsSiglec-1
2019
Increased Expression of Type 1 Interferon Stimulated Genes in Sickle Cell Disease and a Potential Association with RBC Alloimmunization
Madany E, Kadi N, Pandya S, Hendrickson J, Gibb D. Increased Expression of Type 1 Interferon Stimulated Genes in Sickle Cell Disease and a Potential Association with RBC Alloimmunization. Blood 2019, 134: 716. DOI: 10.1182/blood-2019-124899.Peer-Reviewed Original ResearchSickle cell diseaseFrequency of alloimmunizationSickle cell patientsInterferon Stimulated GenesSS patientsCell diseaseType 1 interferonMore alloantibodiesMxA levelsCell patientsSS diseaseRBC alloimmunizationSiglec-1Gene signatureElevated levelsNon-alloimmunized patientsInflammatory autoimmune diseaseChronic inflammatory stateProduction of alloantibodiesHemolytic transfusion reactionsIFN gene signatureExpression of MxAMann-Whitney U testMean fluorescence intensityMyxovirus resistance protein 1
2018
Influenza Infection Induces RBC Alloimmunization By a Type 1 Interferon Dependent Mechanism
Gibb D, Liu D, Liu J, Santhanakrishnan M, Eisenbarth S, Hendrickson J. Influenza Infection Induces RBC Alloimmunization By a Type 1 Interferon Dependent Mechanism. Blood 2018, 132: 743. DOI: 10.1182/blood-2018-99-110884.Peer-Reviewed Original ResearchIFNα/βInfluenza-infected miceRBC alloimmunizationWildtype miceInfluenza infectionTransfusion recipientsRed blood cell transfusionFollicular helper cell differentiationDependent mechanismCompatible blood productsFrequency of alloimmunizationVirus 3 daysBlood cell transfusionIFNα/β productionCertain autoimmune diseasesPro-inflammatory stimuliT cell proliferationInterferon-dependent mechanismRisk of alloimmunizationType 1 interferonLow baseline levelsHelper cell differentiationCell transfusionAlloimmune responseIgG responses
2016
Type 1 Interferon Regulates Inflammation Associated RBC Alloimmunization By Promoting Monocyte-Derived Dendritic Cell Erythrophagocytosis in Mice
Gibb D, Natarajan P, Liu J, Santhanakrishnan M, Iwasaki A, Hendrickson J. Type 1 Interferon Regulates Inflammation Associated RBC Alloimmunization By Promoting Monocyte-Derived Dendritic Cell Erythrophagocytosis in Mice. Blood 2016, 128: 19. DOI: 10.1182/blood.v128.22.19.19.Peer-Reviewed Original ResearchMonocyte-derived dendritic cellsReactivity of seraPeak antibody responseWT miceIfnar1-/- miceType 1 interferonDendritic cellsRBC transfusionPeripheral bloodAntibody responseRBC alloimmunizationAlloimmune responseSpecific IgGIgG antibodiesInflammatory diseasesMouse modelRBC antigensIndividual miceCCR2-/- miceFrequency of alloimmunizationHuman KEL glycoproteinFlow cytometric crossmatchActivation marker expressionDendritic cell activationRole of inflammation