2012
Marginal Zone B Cells Mediate Alloantibody Formation to a Clinically Significant Human RBC Antigen in a Murine Model
Girard-Pierce K, Stowell S, Smith N, Henry K, Zimring J, Hendrickson J. Marginal Zone B Cells Mediate Alloantibody Formation to a Clinically Significant Human RBC Antigen in a Murine Model. Blood 2012, 120: 843. DOI: 10.1182/blood.v120.21.843.843.Peer-Reviewed Original ResearchMZ B cellsHemolytic transfusion reactionsTransfusion of RBCsC57BL/6 recipient miceRecipient miceAlloimmune responseB cellsRBC antigensRBC alloimmunizationAlloantibody responsesPost transfusionMouse modelRBC clearanceFlow cytometryNovel transgenic mouse modelBlood borne antigensConsequences of alloimmunizationControl recipient miceDays post transfusionHuman KEL glycoproteinRBC-specific expressionB-cell depletionRed blood cell antigensAntibody-mediated immunityMarginal zone B cells
2009
Leukoreduction Decreases Alloimmunogenicity of Transfused Murine HOD RBCs.
Hendrickson J, Hod E, Spitalnik S, Hillyer C, Zimring J. Leukoreduction Decreases Alloimmunogenicity of Transfused Murine HOD RBCs. Blood 2009, 114: 640. DOI: 10.1182/blood.v114.22.640.640.Peer-Reviewed Original ResearchWhite blood cellsHOD RBCsPost-transfusion survivalCytometric crossmatchingRBC alloimmunizationLeukoreduction filtersHen egg lysozymeRBC antigensFlow cytometryRBC-specific expressionRed blood cell antigensReductionist murine modelHemolytic transfusion reactionsMinority of miceLateral tail veinAntigen hen egg lysozymeBlood cell antigensEffect of leukoreductionResidual white blood cellsPropridium iodideAltered clearanceHLA alloimmunizationSingle transfusionHLA antigensTransfusion reactions