2024
A simple, field-applicable method to increase the infectivity of wild isolates of Plasmodium falciparum to mosquito vectors
Ouattara S, Hien D, Nao E, Paré P, Guissou E, Cohuet A, Morlais I, Yerbanga R, Dabiré K, Ouédraogo J, Mouline K, Lefèvre T. A simple, field-applicable method to increase the infectivity of wild isolates of Plasmodium falciparum to mosquito vectors. Malaria Journal 2024, 23: 135. PMID: 38711028, PMCID: PMC11075210, DOI: 10.1186/s12936-024-04969-0.Peer-Reviewed Original ResearchConceptsDirect membrane feeding assaysGametocyte densityHuman-to-mosquito transmissionDonor bloodLow gametocyte densitiesMembrane feeding assaysPlasmodium falciparum gametocytesTransmission-blocking interventionsWhole bloodInfection rateFalciparum gametocytesInfectious reservoirNaive serumAsymptomatic individualsMosquito infectionHuman donorsRemoval of plasmaEndemic countriesSerumPlasmodiumParasite isolatesInfectionBlood treatmentGametocytesPlasma volume
2023
Tracking antimalarial drug resistance using mosquito blood meals: a cross-sectional study
Ehrlich H, Somé A, Bazié T, Ebou C, Dembélé E, Balma R, Goodwin J, Wade M, Bei A, Ouédraogo J, Foy B, Dabiré R, Parikh S. Tracking antimalarial drug resistance using mosquito blood meals: a cross-sectional study. The Lancet Microbe 2023, 4: e461-e469. PMID: 37086737, PMCID: PMC10365133, DOI: 10.1016/s2666-5247(23)00063-0.Peer-Reviewed Original ResearchConceptsMosquito blood mealsAntimalarial drug resistanceSurvey 3Blood-fed mosquitoesBlood samplesSurvey 1Survey 2Blood mealDrug resistanceUltrasensitive quantitative PCRHuman blood samplesCross-sectional studyMargin of equivalenceStrong surveillance systemCross-sectional surveySupplementary Materials sectionMarker of clonalityPragmatic thresholdAntimalarial resistanceDrug susceptibilityInfectious diseasesPlasmodium falciparumNational InstituteTolerabilityMaterial section
2022
Evaluation of the Pfs25-IMX313/Matrix-M malaria transmission-blocking candidate vaccine in endemic settings
Mulamba C, Williams C, Kreppel K, Ouedraogo J, Olotu A. Evaluation of the Pfs25-IMX313/Matrix-M malaria transmission-blocking candidate vaccine in endemic settings. Malaria Journal 2022, 21: 159. PMID: 35655174, PMCID: PMC9161629, DOI: 10.1186/s12936-022-04173-y.Peer-Reviewed Original ResearchConceptsEndemic settingsMalaria transmission-blocking vaccineHuman vaccine trialsTransmission-blocking vaccinesPublic health importanceMosquito vectorsMiddle-income settingsAnti-malarial drugsImmunological mechanismsCandidate vaccinesVaccine trialsHealthy individualsIncome settingsTransmission blockingHealth importanceMalaria controlMalaria parasitesVaccineLocal interventionsDrugsInterventionSettingSexual stagesPfs25Disease
2021
Contrasting effects of the alkaloid ricinine on the capacity of Anopheles gambiae and Anopheles coluzzii to transmit Plasmodium falciparum
Hien D, Paré P, Cooper A, Koama B, Guissou E, Yaméogo K, Yerbanga R, Farrell I, Ouédraogo J, Gnankiné O, Ignell R, Cohuet A, Dabiré R, Stevenson P, Lefèvre T. Contrasting effects of the alkaloid ricinine on the capacity of Anopheles gambiae and Anopheles coluzzii to transmit Plasmodium falciparum. Parasites & Vectors 2021, 14: 479. PMID: 34526119, PMCID: PMC8444468, DOI: 10.1186/s13071-021-04992-z.Peer-Reviewed Original ResearchConceptsAnopheles coluzziiAnopheles gambiaeCastor bean Ricinus communisSecondary phytochemicalsKey phenotypic traitsNovel control agentsPlant-derived sugarsAbility of mosquitoesPhenotypic traitsPlasmodium falciparumParasite growth ratePlant sugarsPlant nectarFeeding assaysControl agentsMosquito physiologyGrowth rateAnopheles speciesSensu latoAnopheles gambiae sensu latoColuzziiGambiae sensu latoPutative roleP. falciparum infectionMosquito survivalInsecticide resistance profiles in malaria vector populations from Sud-Kivu in the Democratic Republic of the Congo
N'Do S, Bandibabone J, Soma D, Musaka B, Prudhomme J, Habamungu C, Namountougou M, Sangaré I, Kientega M, Kaboré D, Bayili K, Yerbanga R, Diabate A, Dabire R, Ouedraogo J, Belem A, Boëte C, Guardiola-Claramonte M, Chimanuka B. Insecticide resistance profiles in malaria vector populations from Sud-Kivu in the Democratic Republic of the Congo. Transactions Of The Royal Society Of Tropical Medicine And Hygiene 2021, 115: 1339-1344. PMID: 34324683, DOI: 10.1093/trstmh/trab116.Peer-Reviewed Original ResearchConceptsA. gambiaeInsecticide resistance profileInsecticide resistanceAce-1R mutationMalaria vector populationsVector populationsInsecticide susceptibility bioassaysWild populationsAce-1RPiperonyl butoxideAnopheles gambiaeKdr mutationSusceptibility bioassaysSusceptibility of vectorsMosquito speciesGambiaeAnopheles funestusVector susceptibilitySud-KivuMutationsA. funestusVector control toolsResistance statusEffect of seasonal malaria chemoprevention plus azithromycin on Plasmodium falciparum transmission: gametocyte infectivity and mosquito fitness
Yaméogo K, Yerbanga R, Ouattara S, Yao F, Lefèvre T, Zongo I, Nikièma F, Compaoré Y, Tinto H, Chandramohan D, Greenwood B, Belem A, Cohuet A, Ouédraogo J. Effect of seasonal malaria chemoprevention plus azithromycin on Plasmodium falciparum transmission: gametocyte infectivity and mosquito fitness. Malaria Journal 2021, 20: 326. PMID: 34315475, PMCID: PMC8314489, DOI: 10.1186/s12936-021-03855-3.Peer-Reviewed Original ResearchConceptsAddition of azithromycinMalaria chemopreventionSulfadoxine-pyrimethamineGametocyte infectivityAsexual Plasmodium falciparumDirect membrane feeding assaysSeasonal malaria chemopreventionPlacebo-controlled trialPlasmodium falciparum transmissionMembrane feeding assaysInfectivity of gametocytesControl of malariaPresence of malariaMalaria transmission periodDays post treatmentAnopheles gambiae mosquitoesGametocyte prevalenceMethodsThe studyConclusionThis studyMalaria transmissionP. falciparumControl childrenMosquito transmissionAppropriate interventionsChemoprevention
2020
High Plasmodium infection intensity in naturally infected malaria vectors in Africa
Bompard A, Da D, Yerbanga S, Morlais I, Awono-Ambéné P, Dabiré R, Ouédraogo J, Lefèvre T, Churcher T, Cohuet A. High Plasmodium infection intensity in naturally infected malaria vectors in Africa. International Journal For Parasitology 2020, 50: 985-996. PMID: 32681932, DOI: 10.1016/j.ijpara.2020.05.012.Peer-Reviewed Original ResearchConceptsOocyst-positive mosquitoesInfectious blood mealEfficacy of transmissionControl of malariaWild malaria vectorsMalaria parasite transmissionCross-sectional surveyInfection loadSalivary gland sporozoitesMalaria vectorsMalaria endemicityNumber of oocystsInfected mosquitoesMalaria transmissionOocyst prevalenceStrong positive associationPrevalencePositive associationBlood mealOocyst loadInfection intensityEpidemiologyEfficacyParasite transmissionInterventionDifferent distribution of malaria parasite in left and right extremities of vertebrate hosts translates into differences in parasite transmission
Pigeault R, Isaïa J, Yerbanga R, Dabiré K, Ouédraogo J, Cohuet A, Lefèvre T, Christe P. Different distribution of malaria parasite in left and right extremities of vertebrate hosts translates into differences in parasite transmission. Scientific Reports 2020, 10: 10183. PMID: 32576924, PMCID: PMC7311528, DOI: 10.1038/s41598-020-67180-6.Peer-Reviewed Original ResearchConceptsGametocyte densityMosquito infection ratesBlood samplesInfection rateNew malaria control strategiesMajor global causeMalaria control strategiesLow parasite burdenGametocyte burdenGametocyte carriersParasite transmissionPlasmodium infectionMosquito transmission potentialRight extremitiesTransmissible stagesParasite burdenMosquito transmissionMalaria parasitesPlasmodium sppGlobal causeTransmission potentialGametocytesVector-borne diseasesDiseaseExtremities
2019
Chromatin changes in Anopheles gambiae induced by Plasmodium falciparum infection
Ruiz J, Yerbanga R, Lefèvre T, Ouedraogo J, Corces V, Gómez-Díaz E. Chromatin changes in Anopheles gambiae induced by Plasmodium falciparum infection. Epigenetics & Chromatin 2019, 12: 5. PMID: 30616642, PMCID: PMC6322293, DOI: 10.1186/s13072-018-0250-9.Peer-Reviewed Original ResearchConceptsTranscription factorsHistone modificationsChromatin changesGenome-wide distribution mapsInfection-responsive genesHuman malaria parasite Plasmodium falciparumPeptide-encoding genesMalaria parasite Plasmodium falciparumHistone modification enrichmentDorsal transcription factorParasite Plasmodium falciparumImmunity gene expressionJAK/STATHuman malaria parasiteAnopheles gambiae mosquitoesEpigenetic basisFunctional annotationMotif analysisChIP-seqPhenotypic traitsRNA-seqRegulatory elementsGenetic manipulationNatural isolatesAnopheles gambiae
2018
Antibody Persistence at the Population Level 5 Years After Mass Vaccination With Meningococcal Serogroup A Conjugate Vaccine (PsA-TT) in Burkina Faso: Need for a Booster Campaign?
Yaro S, Lafourcade B, Ouangraoua S, Ouoba A, Kpoda H, Findlow H, Tall H, Seanehia J, Martin C, Ouedraogo J, Gessner B, Meda N, Borrow R, Trotter C, Mueller J. Antibody Persistence at the Population Level 5 Years After Mass Vaccination With Meningococcal Serogroup A Conjugate Vaccine (PsA-TT) in Burkina Faso: Need for a Booster Campaign? Clinical Infectious Diseases 2018, 68: 435-443. PMID: 30481265, DOI: 10.1093/cid/ciy488.Peer-Reviewed Original ResearchConceptsPre-vaccination levelsAge groupsBooster campaignAntibody persistenceMeningococcal serogroup A conjugate vaccineSerum bactericidal antibody titersBactericidal antibody titersYounger age groupsOlder age groupsImmunoglobulin G concentrationCross-sectional surveyTime of returnDifferent age groupsConjugate vaccineAntibody titersImmune protectionGeneral populationMass vaccinationSerological surveyComplete returnOlder individualsMass campaignsBurkina FasoGeometric meanBobo-DioulassoEffectiveness of a community-based educational programme in reducing the cumulative incidence and prevalence of human Taenia solium cysticercosis in Burkina Faso in 2011–14 (EFECAB): a cluster-randomised controlled trial
Carabin H, Millogo A, Ngowi H, Bauer C, Dermauw V, Koné A, Sahlu I, Salvator A, Preux P, Somé T, Tarnagda Z, Gabriël S, Cissé R, Ouédraogo J, Cowan L, Boncoeur-Martel M, Dorny P, Ganaba R. Effectiveness of a community-based educational programme in reducing the cumulative incidence and prevalence of human Taenia solium cysticercosis in Burkina Faso in 2011–14 (EFECAB): a cluster-randomised controlled trial. The Lancet Global Health 2018, 6: e411-e425. PMID: 29530423, PMCID: PMC5873982, DOI: 10.1016/s2214-109x(18)30027-5.Peer-Reviewed Original ResearchConceptsCumulative incidenceHuman cysticercosisActive cysticercosisHuman Taenia solium cysticercosisCommunity-based educational interventionDrug-free interventionsTaenia solium transmissionCommunity-based educational programTaenia solium cysticercosisLow-resource settingsPrevalence of cysticercosisEligible villagesPrimary outcomeUS National InstitutesSolium transmissionBlood samplesFinal sample sizeControl groupSolium cysticercosisCysticercosisCysticercosis prevalenceRandomisationEducational interventionPrevalenceIncidence
2017
Epigenetic regulation of Plasmodium falciparum clonally variant gene expression during development in Anopheles gambiae
Gómez-Díaz E, Yerbanga R, Lefèvre T, Cohuet A, Rowley M, Ouedraogo J, Corces V. Epigenetic regulation of Plasmodium falciparum clonally variant gene expression during development in Anopheles gambiae. Scientific Reports 2017, 7: 40655. PMID: 28091569, PMCID: PMC5238449, DOI: 10.1038/srep40655.Peer-Reviewed Original ResearchConceptsAP2 transcription factorsVar genesTranscription factorsAntisense long non-coding RNAProtein-coding transcriptsSingle var geneLong non-coding RNAsVariant gene expressionNon-coding RNAsVar gene transcriptionChromatin statePhenotypic plasticityHistone modificationsMultigene familyEpigenetic regulationAntisense lncRNAsGene transcriptionAnopheles gambiaeGene expressionIntraerythrocytic cycleMosquito hostSporogonic developmentTranscriptionParasite developmentGenes
2016
Plant-Mediated Effects on Mosquito Capacity to Transmit Human Malaria
Hien D, Dabiré K, Roche B, Diabaté A, Yerbanga R, Cohuet A, Yameogo B, Gouagna L, Hopkins R, Ouedraogo G, Simard F, Ouedraogo J, Ignell R, Lefevre T. Plant-Mediated Effects on Mosquito Capacity to Transmit Human Malaria. PLOS Pathogens 2016, 12: e1005773. PMID: 27490374, PMCID: PMC4973987, DOI: 10.1371/journal.ppat.1005773.Peer-Reviewed Original ResearchConceptsImportant African malaria vectorsHost resource availabilityMalaria parasitesMalaria vectorsSugar sourcesSugar mealsAfrican malaria vectorsToxic secondary metabolitesNutritional ecologyPlant speciesMosquito traitsMosquito competenceNatural diversityFeeding assaysLannea microcarpaMosquito's capacityEcological contextSecondary metabolitesMolecular aspectsMalaria transmissionParasite growthResource availabilityDirect membrane feeding assaysDevelopment durationHuman malariaNeemazal ® as a possible alternative control tool for malaria and African trypanosomiasis?
Yerbanga R, Rayaisse J, Vantaux A, Salou E, Mouline K, Hien F, Habluetzel A, Dabiré R, Ouédraogo J, Solano P, Lefèvre T. Neemazal ® as a possible alternative control tool for malaria and African trypanosomiasis? Parasites & Vectors 2016, 9: 263. PMID: 27146309, PMCID: PMC4857419, DOI: 10.1186/s13071-016-1538-x.Peer-Reviewed Original ResearchConceptsAfrican trypanosomiasisEffect of bloodOral dosesBehavioral alterationsConclusionThis studyAnthropophilic rateDifferent dosesMembrane feedingAlternative control toolsDosesCalf odourPromising activityMalariaMiceBloodDoseVector control programsHost stimuliAdditional researchControl programsPlant remediesBehavioral responsesG. palpalis gambiensisTrypanosomiasisBloodmealEvaluation of the Antiplasmodial Activity and Lethality of the Leaf Extract of <I>Cassia alata</I> L. (Fabaceae)
Da O, Yerbanga R, Traore/Coulibaly M, Koama B, Kabre Z, Tamboura S, Dakuyo Z, Sekhoacha M, Matsabisa M, Nikiema J, Ouedraogo J, Ouedraogo G. Evaluation of the Antiplasmodial Activity and Lethality of the Leaf Extract of Cassia alata L. (Fabaceae). Pakistan Journal Of Biological Sciences 2016, 19: 171-178. PMID: 29022993, DOI: 10.3923/pjbs.2016.171.178.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsAntimalarialsCassiaDisease Models, AnimalFemaleLethal Dose 50L-Lactate DehydrogenaseMalaria, FalciparumMaleMaximum Tolerated DoseMethanolMethylene ChlorideMiceParasitic Sensitivity TestsPhytotherapyPlant ExtractsPlant LeavesPlants, MedicinalPlasmodium falciparumProtozoan ProteinsSolventsConceptsVivo antiplasmodial activityBody weightAntiplasmodial activityPlasmodium falciparumMean percent suppressionDay suppressive testChloroquine-sensitive strainNon-lethal doseParasite lactate dehydrogenase assayAnimal body weightMaximum non-lethal doseMethanol leaf extractSuppressive testSignificant changesLactate dehydrogenase assayOral routePercent suppressionHematological parametersHigh dosesHaematological parametersPlasmodium bergheiMiceAntimalarial potentialLeaf extractCassia alata
2015
Meningococcal Seroepidemiology 1 Year After the PsA-TT Mass Immunization Campaign in Burkina Faso
Tall H, Yaro S, Kpoda H, Ouangraoua S, Trotter C, Lafourcade B, Findlow H, Bai X, Martin C, Nwakamma I, Ouedraogo J, Gessner B, Borrow R, Mueller J. Meningococcal Seroepidemiology 1 Year After the PsA-TT Mass Immunization Campaign in Burkina Faso. Clinical Infectious Diseases 2015, 61: s540-s546. PMID: 26553686, PMCID: PMC4639492, DOI: 10.1093/cid/civ519.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAdultAnimalsAntibodies, BacterialBlood Bactericidal ActivityBurkina FasoChildChild, PreschoolComplement System ProteinsFemaleHumansImmunoglobulin GInfantMaleMass VaccinationMeningitis, MeningococcalMeningococcal VaccinesNeisseria meningitidis, Serogroup ARabbitsSeroepidemiologic StudiesYoung AdultConceptsAntibody titersSerum bactericidal antibody titersVaccine-eligible age groupsBactericidal antibody titersGeometric mean titersAfrican meningitis beltPopulation-level immunitySpecific antibody titersMass immunization campaignOptimal vaccination strategyImmunoglobulin G concentrationLong-term controlPsA-TTMean titersVaccine coverageProtective antibodiesMeningitis beltBlood drawVaccination strategiesImmunization campaignRabbit complementGroup AHigh seroprevalenceStandardized interviewAge groupsPlasmodium transmission blocking activities of Vernonia amygdalina extracts and isolated compounds
Abay S, Lucantoni L, Dahiya N, Dori G, Dembo E, Esposito F, Lupidi G, Ogboi S, Ouédraogo R, Sinisi A, Taglialatela-Scafati O, Yerbanga R, Bramucci M, Quassinti L, Ouédraogo J, Christophides G, Habluetzel A. Plasmodium transmission blocking activities of Vernonia amygdalina extracts and isolated compounds. Malaria Journal 2015, 14: 288. PMID: 26208861, PMCID: PMC4513948, DOI: 10.1186/s12936-015-0812-2.Peer-Reviewed Original ResearchConceptsEarly sporogonic stagesOocyst prevalenceVivo transmissionHuman parasite P. falciparumP. berghei parasitesMalaria control toolsAnopheles stephensi mosquitoesEthanolic leaf extractVernonia amygdalina extractPreventive treatmentBerghei parasitesField isolatesAnopheles coluzzii mosquitoesParasite P. falciparumP. falciparumBackgroundMedicinal plantsStephensi mosquitoesPlasmodium transmissionHerbal medicineMurine parasitePlasmodium falciparumLeaf extractPrevalenceCytotoxic effectsSporogonic stagesAntibiotics in ingested human blood affect the mosquito microbiota and capacity to transmit malaria
Gendrin M, Rodgers F, Yerbanga R, Ouédraogo J, Basáñez M, Cohuet A, Christophides G. Antibiotics in ingested human blood affect the mosquito microbiota and capacity to transmit malaria. Nature Communications 2015, 6: 5921. PMID: 25562286, PMCID: PMC4338536, DOI: 10.1038/ncomms6921.Peer-Reviewed Original ResearchConceptsMass drug administration programsHigh antibiotic usageDrug administration programsBlood of childrenAnopheles gambiae mosquitoesMalaria infectionAntibiotic exposureMosquito bitesHigh riskAntibiotic usageMalaria reductionGut microbiotaMalaria transmissionCommunicable diseasesPlasmodium falciparumBloodIngested bloodGambiae mosquitoesAntibioticsHuman bloodDisease transmissionDiseaseMosquito survivalMosquito microbiotaVectorial capacity
2014
Experimental study of the relationship between Plasmodium gametocyte density and infection success in mosquitoes; implications for the evaluation of malaria transmission-reducing interventions
Da D, Churcher T, Yerbanga R, Yaméogo B, Sangaré I, Ouedraogo J, Sinden R, Blagborough A, Cohuet A. Experimental study of the relationship between Plasmodium gametocyte density and infection success in mosquitoes; implications for the evaluation of malaria transmission-reducing interventions. Experimental Parasitology 2014, 149: 74-83. PMID: 25541384, DOI: 10.1016/j.exppara.2014.12.010.Peer-Reviewed Original ResearchConceptsGametocyte densityParasite densityBlood samplesInfected bloodMouse bloodInfectious blood samplesMembrane feeding assaysPlasmodium berghei infectionTransmission-reducing interventionsPlasmodium falciparum samplesBlood dilutionEvaluation of transmissionInfected mouse bloodBerghei infectionPlasmodium infectionMosquito infectivityAnopheles coluzzii mosquitoesInhibitory factorMonoclonal antibodiesBloodAccurate relative measuresInfectionUninfected bloodHost bloodColuzzii mosquitoesTransmission blocking activity of Azadirachta indica and Guiera senegalensis extracts on the sporogonic development of Plasmodium falciparum field isolates in Anopheles coluzzii mosquitoes
Yerbanga R, Lucantoni L, Ouédraogo R, Da D, Yao F, Yaméogo K, Churcher T, Lupidi G, Taglialatela-Scafati O, Gouagna L, Cohuet A, Christophides G, Ouédraogo J, Habluetzel A. Transmission blocking activity of Azadirachta indica and Guiera senegalensis extracts on the sporogonic development of Plasmodium falciparum field isolates in Anopheles coluzzii mosquitoes. Parasites & Vectors 2014, 7: 185. PMID: 24735564, PMCID: PMC3996177, DOI: 10.1186/1756-3305-7-185.Peer-Reviewed Original ResearchConceptsOocyst prevalencePlasmodium falciparum fieldMalaria control toolsLate-stage gametocytesAnopheles coluzzii femalesEvidence of transmissionPharmacological strategiesAntiplasmodial effectCombination treatmentAnopheles coluzzii mosquitoesAntimalarial drugsMalaria controlMalaria parasitesPlasmodium falciparumMembrane feedingMosquito midgutHerbal formulationsGuiera senegalensisEthyl acetate extractPlant extractsEthanol extractHuman hostColuzzii mosquitoesNeem tree Azadirachta indicaOocyst density