Evaluation of the Antiplasmodial Activity and Lethality of the Leaf Extract of <I>Cassia alata</I> L. (Fabaceae)
Da O, Yerbanga R, Traore/Coulibaly M, Koama B, Kabre Z, Tamboura S, Dakuyo Z, Sekhoacha M, Matsabisa M, Nikiema J, Ouedraogo J, Ouedraogo G. Evaluation of the Antiplasmodial Activity and Lethality of the Leaf Extract of Cassia alata L. (Fabaceae). Pakistan Journal Of Biological Sciences 2016, 19: 171-178. PMID: 29022993, DOI: 10.3923/pjbs.2016.171.178.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsAntimalarialsCassiaDisease Models, AnimalFemaleLethal Dose 50L-Lactate DehydrogenaseMalaria, FalciparumMaleMaximum Tolerated DoseMethanolMethylene ChlorideMiceParasitic Sensitivity TestsPhytotherapyPlant ExtractsPlant LeavesPlants, MedicinalPlasmodium falciparumProtozoan ProteinsSolventsConceptsVivo antiplasmodial activityBody weightAntiplasmodial activityPlasmodium falciparumMean percent suppressionDay suppressive testChloroquine-sensitive strainNon-lethal doseParasite lactate dehydrogenase assayAnimal body weightMaximum non-lethal doseMethanol leaf extractSuppressive testSignificant changesLactate dehydrogenase assayOral routePercent suppressionHematological parametersHigh dosesHaematological parametersPlasmodium bergheiMiceAntimalarial potentialLeaf extractCassia alata