A Worldwide Map of Plasmodium falciparum K13-Propeller Polymorphisms
Ménard D, Khim N, Beghain J, Adegnika A, Shafiul-Alam M, Amodu O, Rahim-Awab G, Barnadas C, Berry A, Boum Y, Bustos M, Cao J, Chen J, Collet L, Cui L, Thakur G, Dieye A, Djallé D, Dorkenoo M, Eboumbou-Moukoko C, Espino F, Fandeur T, Ferreira-da-Cruz M, Fola A, Fuehrer H, Hassan A, Herrera S, Hongvanthong B, Houzé S, Ibrahim M, Jahirul-Karim M, Jiang L, Kano S, Ali-Khan W, Khanthavong M, Kremsner P, Lacerda M, Leang R, Leelawong M, Li M, Lin K, Mazarati J, Ménard S, Morlais I, Muhindo-Mavoko H, Musset L, Na-Bangchang K, Nambozi M, Niaré K, Noedl H, Ouédraogo J, Pillai D, Pradines B, Quang-Phuc B, Ramharter M, Randrianarivelojosia M, Sattabongkot J, Sheikh-Omar A, Silué K, Sirima S, Sutherland C, Syafruddin D, Tahar R, Tang L, Touré O, Tshibangu-wa-Tshibangu P, Vigan-Womas I, Warsame M, Wini L, Zakeri S, Kim S, Eam R, Berne L, Khean C, Chy S, Ken M, Loch K, Canier L, Duru V, Legrand E, Barale J, Stokes B, Straimer J, Witkowski B, Fidock D, Rogier C, Ringwald P, Ariey F, Mercereau-Puijalon O. A Worldwide Map of Plasmodium falciparum K13-Propeller Polymorphisms. New England Journal Of Medicine 2016, 374: 2453-2464. PMID: 27332904, PMCID: PMC4955562, DOI: 10.1056/nejmoa1513137.Peer-Reviewed Original ResearchConceptsK13 mutationsRing-stage survival assayK13-propeller polymorphismsPlasmodium falciparum resistanceA578S mutationParasite clearanceRare nonsynonymous mutationsFalciparum resistanceAntimalarial resistanceArtemisinin resistanceNationwide surveillanceGlobal burdenSentinel sitesGeographic disparitiesSurvival assaysP. falciparum genesMalariaPropeller domainMajor determinantArtemisininMutationsNonsynonymous mutationsSuch resistancePolymorphismPatientsGenomic epidemiology of artemisinin resistant malaria
Amato R, Miotto O, Woodrow C, Almagro-Garcia J, Sinha I, Campino S, Mead D, Drury E, Kekre M, Sanders M, Amambua-Ngwa A, Amaratunga C, Amenga-Etego L, Andrianaranjaka V, Apinjoh T, Ashley E, Auburn S, Awandare G, Baraka V, Barry A, Boni M, Borrmann S, Bousema T, Branch O, Bull P, Chotivanich K, Conway D, Craig A, Day N, Djimdé A, Dolecek C, Dondorp A, Drakeley C, Duffy P, Echeverry D, Egwang T, Fairhurst R, Faiz A, Fanello C, Hien T, Hodgson A, Imwong M, Ishengoma D, Lim P, Lon C, Marfurt J, Marsh K, Mayxay M, Michon P, Mobegi V, Mokuolu O, Montgomery J, Mueller I, Kyaw M, Newton P, Nosten F, Noviyanti R, Nzila A, Ocholla H, Oduro A, Onyamboko M, Ouedraogo J, Phyo A, Plowe C, Price R, Pukrittayakamee S, Randrianarivelojosia M, Ringwald P, Ruiz L, Saunders D, Shayo A, Siba P, Takala-Harrison S, Thanh T, Thathy V, Verra F, Wendler J, White N, Ye H, Cornelius V, Giacomantonio R, Muddyman D, Henrichs C, Malangone C, Jyothi D, Pearson R, Rayner J, McVean G, Rockett K, Miles A, Vauterin P, Jeffery B, Manske M, Stalker J, MacInnis B, Kwiatkowski D. Genomic epidemiology of artemisinin resistant malaria. ELife 2016, 5: e08714. PMID: 26943619, PMCID: PMC4786412, DOI: 10.7554/elife.08714.Peer-Reviewed Original ResearchMeSH KeywordsAfricaAntimalarialsArtemisininsAsia, SoutheasternDrug ResistanceMalaria, FalciparumMolecular EpidemiologyPlasmodium falciparumConceptsKelch13 mutationsArtemisinin-resistant Plasmodium falciparumArtemisinin-resistant malariaResistant Plasmodium falciparumGenomic epidemiologyLarge global surveyPublic health surveillanceArtemisinin resistanceResistant malariaCurrent epidemicHealth surveillancePlasmodium falciparumAmino acid changesEpidemiologyKelch13Non-synonymous mutations