Efficacy and Day 7 Plasma Piperaquine Concentrations in African Children Treated for Uncomplicated Malaria with Dihydroartemisinin-Piperaquine
Zongo I, Somé FA, Somda SA, Parikh S, Rouamba N, Rosenthal PJ, Tarning J, Lindegardh N, Nosten F, Ouédraogo JB. Efficacy and Day 7 Plasma Piperaquine Concentrations in African Children Treated for Uncomplicated Malaria with Dihydroartemisinin-Piperaquine. PLOS ONE 2014, 9: e103200. PMID: 25133389, PMCID: PMC4136730, DOI: 10.1371/journal.pone.0103200.Peer-Reviewed Original ResearchConceptsDHA-PQRecurrent malariaDaily dosePlasma concentrationsSingle-arm open-label trialHigher median plasma concentrationsFalciparum malaria treatmentMedian daily dosePharmacokinetics of piperaquineRate of recrudescenceOpen-label trialUncomplicated falciparum malariaMedian plasma concentrationVenous plasma concentrationsSuccessful treatment outcomeDihydroartemisinin-PiperaquineExploratory endpointsParasitological efficacyPiperaquine concentrationsUncomplicated malariaOverall recurrenceYounger patientsFalciparum malariaClinical efficacyCombination therapy