2017
Modulation of Endothelial Bone Morphogenetic Protein Receptor Type 2 Activity by Vascular Endothelial Growth Factor Receptor 3 in Pulmonary Arterial Hypertension
Hwangbo C, Lee HW, Kang H, Ju H, Wiley DS, Papangeli I, Han J, Kim JD, Dunworth WP, Hu X, Lee S, El-Hely O, Sofer A, Pak B, Peterson L, Comhair S, Hwang EM, Park JY, Thomas J, Bautch VL, Erzurum SC, Chun HJ, Jin SW. Modulation of Endothelial Bone Morphogenetic Protein Receptor Type 2 Activity by Vascular Endothelial Growth Factor Receptor 3 in Pulmonary Arterial Hypertension. Circulation 2017, 135: 2288-2298. PMID: 28356442, PMCID: PMC5523010, DOI: 10.1161/circulationaha.116.025390.Peer-Reviewed Original ResearchConceptsBMP receptor type 2Vascular endothelial growth factor receptor 3Growth factor receptor 3Zebrafish embryosPulmonary arterial endothelial cellsArterial endothelial cellsVEGFR3 expressionBone morphogenetic protein (BMP) signalingPulmonary arterial hypertensionMorphogenetic protein signalingEndothelial cellsFamilial pulmonary arterial hypertensionBMPR2 functionsPrimary lung endothelial cellsImpaired BMPBMP signalingBMP stimulationProtein signalingReceptor 3Endothelial-specific deletionEctopic angiogenesisKey regulatorHuman endothelial cellsArterial hypertensionLung endothelial cells
2015
Vascular remodeling is governed by a VEGFR3-dependent fluid shear stress set point
Baeyens N, Nicoli S, Coon BG, Ross TD, Van den Dries K, Han J, Lauridsen HM, Mejean CO, Eichmann A, Thomas JL, Humphrey JD, Schwartz MA. Vascular remodeling is governed by a VEGFR3-dependent fluid shear stress set point. ELife 2015, 4: e04645. PMID: 25643397, PMCID: PMC4337723, DOI: 10.7554/elife.04645.Peer-Reviewed Original Research
2012
Molecular Parallels between Neural and Vascular Development
Eichmann A, Thomas JL. Molecular Parallels between Neural and Vascular Development. Cold Spring Harbor Perspectives In Medicine 2012, 3: a006551. PMID: 23024177, PMCID: PMC3530036, DOI: 10.1101/cshperspect.a006551.Peer-Reviewed Original ResearchConceptsCentral nervous systemAdult neurogenic nichesMolecular parallelsNeural stem cellsCardiac outputMolecular mechanismsBlood vesselsNeurovascular interactionsVascular developmentHuman diseasesStem cellsCNS blood vesselsHuman central nervous systemBlood-brain barrierVascular endothelial growth factorNeurogenic nicheCell populationsEndothelial growth factorGrowth factorEndothelial cellsBlood glucoseNervous systemImportant roleCellsUnique population
2007
Activation of the UNC5B receptor by Netrin-1 inhibits sprouting angiogenesis
Larrivée B, Freitas C, Trombe M, Lv X, DeLafarge B, Yuan L, Bouvrée K, Bréant C, Del Toro R, Bréchot N, Germain S, Bono F, Dol F, Claes F, Fischer C, Autiero M, Thomas JL, Carmeliet P, Tessier-Lavigne M, Eichmann A. Activation of the UNC5B receptor by Netrin-1 inhibits sprouting angiogenesis. Genes & Development 2007, 21: 2433-2447. PMID: 17908930, PMCID: PMC1993874, DOI: 10.1101/gad.437807.Peer-Reviewed Original ResearchConceptsNetrin receptor UNC5BFull-length receptorVascular patterningEmbryonic developmentPotential anti-angiogenic targetCell repulsionGenetic lossSprouting angiogenesisAdult vasculaturePathological angiogenesisReceptor UNC5BUNC5B receptorUNC5BAnti-angiogenic targetAxonal growthAngiogenesisNetrin-1InhibitsActivation inhibitsReceptorsNetrinAngiogenesis inhibitionPatterningMatrigelIntracellular
2004
The netrin receptor UNC5B mediates guidance events controlling morphogenesis of the vascular system
Lu X, le Noble F, Yuan L, Jiang Q, de Lafarge B, Sugiyama D, Bréant C, Claes F, De Smet F, Thomas JL, Autiero M, Carmeliet P, Tessier-Lavigne M, Eichmann A. The netrin receptor UNC5B mediates guidance events controlling morphogenesis of the vascular system. Nature 2004, 432: 179-186. PMID: 15510105, DOI: 10.1038/nature03080.Peer-Reviewed Original ResearchConceptsNetrin receptor UNC5BEndothelial tip cell filopodiaTip cell filopodiaReceptor UNC5BEndothelial tip cellsVascular systemNetrin-1aTip cellsEndothelial cellsProper wiringAxon guidanceCell filopodiaNetrin receptorsGuidance eventsFilopodial retractionMorphogenesisUNC5BVessel branchingAberrant extensionAnatomical similaritiesNetrin-1CellsZebrafishGenesGuidance function