2022
Identification of growth hormone receptor as a relevant target for precision medicine in low‐EGFR expressing glioblastoma
Verreault M, Vilchis I, Rosenberg S, Lemaire N, Schmitt C, Guehennec J, Royer‐Perron L, Thomas J, Lam TT, Dingli F, Loew D, Ducray F, Paris S, Carpentier C, Marie Y, Laigle‐Donadey F, Rousseau A, Pigat N, Boutillon F, Bielle F, Mokhtari K, Frank SJ, de Reyniès A, Hoang‐Xuan K, Sanson M, Goffin V, Idbaih A. Identification of growth hormone receptor as a relevant target for precision medicine in low‐EGFR expressing glioblastoma. Clinical And Translational Medicine 2022, 12: e939. PMID: 35808822, PMCID: PMC9270581, DOI: 10.1002/ctm2.939.Peer-Reviewed Original ResearchMeSH KeywordsBrain NeoplasmsCell Line, TumorErbB ReceptorsGlioblastomaHumansPrecision MedicineReceptors, SomatotropinConceptsEpidermal growth factor receptorGrowth hormone receptorPatient-derived cell linesOncogenic mechanismsGene expression profilesCell linesGain of functionHormone receptorsExpression of proteinsCellular movementGrowth factor receptorHuman GBM samplesExpression profilesCell migrationCommon oncogenic mechanismThird of patientsDistinct molecular subsetsGBM samplesPromoter hypermethylationNew therapeutic approachesFactor receptorCell proliferationPharmacological inhibitionRelevant targetsOverexpression
2014
Tumor and Endothelial Cell Hybrids Participate in Glioblastoma Vasculature
Hallani S, Colin C, Houfi Y, Idbaih A, Boisselier B, Marie Y, Ravassard P, Labussière M, Mokhtari K, Thomas JL, Delattre JY, Eichmann A, Sanson M. Tumor and Endothelial Cell Hybrids Participate in Glioblastoma Vasculature. BioMed Research International 2014, 2014: 827327. PMID: 24868550, PMCID: PMC4017715, DOI: 10.1155/2014/827327.Peer-Reviewed Original ResearchAntigens, CDBrain NeoplasmsCadherinsCell DifferentiationCell ProliferationCoculture TechniquesEndoglinEndothelial CellsErbB ReceptorsGene Expression Regulation, NeoplasticGlioblastomaGreen Fluorescent ProteinsHuman Umbilical Vein Endothelial CellsHumansIn Situ Hybridization, FluorescenceLentivirusMicrocirculationNeoplasmsNeovascularization, PathologicPhenotypePlatelet Endothelial Cell Adhesion Molecule-1Receptors, Cell Surface