Live Imaging of Targeted Cell Ablation in Xenopus: A New Model to Study Demyelination and Repair
Kaya F, Mannioui A, Chesneau A, Sekizar S, Maillard E, Ballagny C, Houel-Renault L, DuPasquier D, Bronchain O, Holtzmann I, Desmazieres A, Thomas JL, Demeneix BA, Brophy PJ, Zalc B, Mazabraud A. Live Imaging of Targeted Cell Ablation in Xenopus: A New Model to Study Demyelination and Repair. Journal Of Neuroscience 2012, 32: 12885-12895. PMID: 22973012, PMCID: PMC3460536, DOI: 10.1523/jneurosci.2252-12.2012.Peer-Reviewed Original ResearchConceptsDemyelination/remyelination processesProcess of demyelinationAxonal damageRemyelination processMyelin repairOligodendrocyte ablationMTZ treatmentTwo-photon imagingVivo modelTargeted cell ablationMetronidazoleTherapeutic agentsConditional ablationRetinoic acidOligodendrocytesDemyelinationRemyelination