The Xenopus tadpole: An in vivo model to screen drugs favoring remyelination
Mannioui A, Vauzanges Q, Fini JB, Henriet E, Sekizar S, Azoyan L, Thomas JL, Du Pasquier D, Giovannangeli C, Demeneix B, Lubetzki C, Zalc B. The Xenopus tadpole: An in vivo model to screen drugs favoring remyelination. Multiple Sclerosis Journal 2017, 24: 1421-1432. PMID: 28752787, DOI: 10.1177/1352458517721355.Peer-Reviewed Original ResearchConceptsSphingosine-1-phosphate receptor 5Receptor 5Sphingosine-1-phosphate receptor 1Efficacy of siponimodNumber of oligodendrocytesSpontaneous remyelinationMultiple sclerosisOptic nervePromyelinating effectE. coli nitroreductaseRemyelinationDual agonistsVivo modelReceptor 1SiponimodConditional ablationOligodendrocytesXenopus tadpolesVivo screeningCRISPR/Cas9 gene editingVivoCas9 gene editingDemyelinationSclerosisGreen fluorescent protein reporter