2022
CatSper and Two-Pore channels (TPC) in GtoPdb v.2022.1
Chung J, Clapham D, Garbers D, Grimm C, Ren D. CatSper and Two-Pore channels (TPC) in GtoPdb v.2022.1. IUPHAR/BPS Guide To Pharmacology CITE 2022, 2022 DOI: 10.2218/gtopdb/f70/2022.1.Peer-Reviewed Original ResearchTwo-pore channelsCatSper channelsCatSper subunitsLike subunitsPlasma membraneSperm tailPrinciple pieceCatSperIndividual domainsTPC1TPC3Number of TMGtoPdb v.TPC2SubunitsProteinVoltage-activated calcium channelsPermeant channelsChannel inhibitorsPatch clampCalcium channelsEndosomesMammalsCatSper1Lysosomes
2019
CatSper and Two-Pore channels (version 2019.4) in the IUPHAR/BPS Guide to Pharmacology Database
Chung J, Clapham D, Garbers D, Ren D. CatSper and Two-Pore channels (version 2019.4) in the IUPHAR/BPS Guide to Pharmacology Database. IUPHAR/BPS Guide To Pharmacology CITE 2019, 2019 DOI: 10.2218/gtopdb/f70/2019.4.Peer-Reviewed Original ResearchTwo-pore channelsCatSper channelsCatSper subunitsLike subunitsPlasma membraneSperm tailIUPHAR/BPS GuidePrinciple pieceCatSperIndividual domainsTPC1Number of TMTPC3TPC2SubunitsProteinVoltage-activated calcium channelsPermeant channelsChannel inhibitorsPatch clampCalcium channelsEndosomesMammalsPharmacology DatabaseCatSper1
2000
Functional impairment of lens aquaporin in two families with dominantly inherited cataracts
Francis P, Chung JJ, Yasui M, Berry V, Moore A, Wyatt MK, Wistow G, Bhattacharya SS, Agre P. Functional impairment of lens aquaporin in two families with dominantly inherited cataracts. Human Molecular Genetics 2000, 9: 2329-2334. PMID: 11001937, DOI: 10.1093/oxfordjournals.hmg.a018925.Peer-Reviewed Original ResearchConceptsAQP0 proteinMutant proteinsWater channel activityDominant-negative behaviorOocyte plasma membraneOocyte expression systemXenopus laevis oocyte expression systemLens aquaporinsDifferent point mutationsPlasma membraneExpression systemSevere defectsPoint mutationsMissense mutationsProteinChannel activityAQP2 proteinRecessive traitFunctional defectsPathophysiological relevanceMutationsCongenital cataractFamilyCataract formationAQP0