2022
CatSper and Two-Pore channels (TPC) in GtoPdb v.2022.1
Chung J, Clapham D, Garbers D, Grimm C, Ren D. CatSper and Two-Pore channels (TPC) in GtoPdb v.2022.1. IUPHAR/BPS Guide To Pharmacology CITE 2022, 2022 DOI: 10.2218/gtopdb/f70/2022.1.Peer-Reviewed Original ResearchTwo-pore channelsCatSper channelsCatSper subunitsLike subunitsPlasma membraneSperm tailPrinciple pieceCatSperIndividual domainsTPC1TPC3Number of TMGtoPdb v.TPC2SubunitsProteinVoltage-activated calcium channelsPermeant channelsChannel inhibitorsPatch clampCalcium channelsEndosomesMammalsCatSper1LysosomesC2cd6-encoded CatSperτ targets sperm calcium channel to Ca2+ signaling domains in the flagellar membrane
Hwang JY, Wang H, Lu Y, Ikawa M, Chung JJ. C2cd6-encoded CatSperτ targets sperm calcium channel to Ca2+ signaling domains in the flagellar membrane. Cell Reports 2022, 38: 110226. PMID: 34998468, PMCID: PMC8857959, DOI: 10.1016/j.celrep.2021.110226.Peer-Reviewed Original ResearchConceptsFlagellar membraneFlagellar membrane targetingC2 domain proteinsCatSper channelsCatSper channel complexMammalian sperm cellsSperm hyperactivated motilityMale fertilityMembrane targetingTrafficking machineryDomain proteinsLoss of functionHyperactivated motilitySpatiotemporal CaChannel assemblyMolecular mechanismsSperm cellsChannel complexFlagellaMotilityC2CD6MembraneCalcium channelsMachineryProtein
2019
CatSper and Two-Pore channels (version 2019.4) in the IUPHAR/BPS Guide to Pharmacology Database
Chung J, Clapham D, Garbers D, Ren D. CatSper and Two-Pore channels (version 2019.4) in the IUPHAR/BPS Guide to Pharmacology Database. IUPHAR/BPS Guide To Pharmacology CITE 2019, 2019 DOI: 10.2218/gtopdb/f70/2019.4.Peer-Reviewed Original ResearchTwo-pore channelsCatSper channelsCatSper subunitsLike subunitsPlasma membraneSperm tailIUPHAR/BPS GuidePrinciple pieceCatSperIndividual domainsTPC1Number of TMTPC3TPC2SubunitsProteinVoltage-activated calcium channelsPermeant channelsChannel inhibitorsPatch clampCalcium channelsEndosomesMammalsPharmacology DatabaseCatSper1Dual Sensing of Physiologic pH and Calcium by EFCAB9 Regulates Sperm Motility
Hwang JY, Mannowetz N, Zhang Y, Everley RA, Gygi SP, Bewersdorf J, Lishko PV, Chung JJ. Dual Sensing of Physiologic pH and Calcium by EFCAB9 Regulates Sperm Motility. Cell 2019, 177: 1480-1494.e19. PMID: 31056283, PMCID: PMC8808721, DOI: 10.1016/j.cell.2019.03.047.Peer-Reviewed Original Research