2023
Lysophosphatidic acid triggers inflammation in the liver and white adipose tissue in rat models of 1-acyl-sn-glycerol-3-phosphate acyltransferase 2 deficiency and overnutrition
Sakuma I, Gaspar R, Luukkonen P, Kahn M, Zhang D, Zhang X, Murray S, Golla J, Vatner D, Samuel V, Petersen K, Shulman G. Lysophosphatidic acid triggers inflammation in the liver and white adipose tissue in rat models of 1-acyl-sn-glycerol-3-phosphate acyltransferase 2 deficiency and overnutrition. Proceedings Of The National Academy Of Sciences Of The United States Of America 2023, 120: e2312666120. PMID: 38127985, PMCID: PMC10756285, DOI: 10.1073/pnas.2312666120.Peer-Reviewed Original Research
2017
Metabolomic Analysis of Mice Exposed to Gamma Radiation Reveals a Systemic Understanding of Total-Body Exposure
Golla S, Golla JP, Krausz KW, Manna SK, Simillion C, Beyoğlu D, Idle JR, Gonzalez FJ. Metabolomic Analysis of Mice Exposed to Gamma Radiation Reveals a Systemic Understanding of Total-Body Exposure. Radiation Research 2017, 187: 612-629. PMID: 28467754, PMCID: PMC5539505, DOI: 10.1667/rr14592.1.Peer-Reviewed Original ResearchConceptsTotal body exposureRadiation exposureUltra-performance liquid chromatography-electrospray ionization-quadrupole timeBile acid metabolismChronic radiation toxicityMultiple radiation exposuresTissue-specific biomarkersMetabolomic analysisPotential novel approachGamma-irradiated groupsRadiation toxicityResponse markersBone marrowFunctional alterationsLiquid chromatography-electrospray ionization-quadrupole timeTriage protocolSpecific biomarkersDiagnostic markerMetabolic signaturesRadiosensitive tissuesMetabolic changesH postirradiationBiomarkersAcid metabolismTissue-level responses
2015
St. John's Wort Attenuates Colorectal Carcinogenesis in Mice through Suppression of Inflammatory Signaling
Manna SK, Golla S, Golla JP, Tanaka N, Cai Y, Takahashi S, Krausz KW, Matsubara T, Korboukh I, Gonzalez FJ. St. John's Wort Attenuates Colorectal Carcinogenesis in Mice through Suppression of Inflammatory Signaling. Cancer Prevention Research 2015, 8: 786-795. PMID: 26069204, PMCID: PMC4584416, DOI: 10.1158/1940-6207.capr-14-0113.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsAnticarcinogenic AgentsAzoxymethaneCarcinogenesisCell Transformation, NeoplasticColonColorectal NeoplasmsDietDietary SupplementsDisease Models, AnimalExtracellular Signal-Regulated MAP KinasesHypericumInflammationMaleMiceNF-kappa BOligonucleotide Array Sequence AnalysisOligonucleotidesPlant ExtractsSignal TransductionConceptsDiet-fed miceSJW extractColorectal carcinogenesisAzoxymethane-induced colorectal carcinogenesisAIN-93G dietLong-term treatment regimensAzoxymethane-treated miceEffect of SJWNuclear factor kappa BBody weight lossWort extractTotal tumor volumeFactor kappa BSt. John's wort extractDose-dependent mannerAzoxymethane treatmentSJW administrationRectal bleedingOverall survivalTreatment regimensColorectal cancerProinflammatory processesTumor multiplicityLarge tumorsCholesterol levels