St. John's Wort Attenuates Colorectal Carcinogenesis in Mice through Suppression of Inflammatory Signaling
Manna SK, Golla S, Golla JP, Tanaka N, Cai Y, Takahashi S, Krausz KW, Matsubara T, Korboukh I, Gonzalez FJ. St. John's Wort Attenuates Colorectal Carcinogenesis in Mice through Suppression of Inflammatory Signaling. Cancer Prevention Research 2015, 8: 786-795. PMID: 26069204, PMCID: PMC4584416, DOI: 10.1158/1940-6207.capr-14-0113.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsAnticarcinogenic AgentsAzoxymethaneCarcinogenesisCell Transformation, NeoplasticColonColorectal NeoplasmsDietDietary SupplementsDisease Models, AnimalExtracellular Signal-Regulated MAP KinasesHypericumInflammationMaleMiceNF-kappa BOligonucleotide Array Sequence AnalysisOligonucleotidesPlant ExtractsSignal TransductionConceptsDiet-fed miceSJW extractColorectal carcinogenesisAzoxymethane-induced colorectal carcinogenesisAIN-93G dietLong-term treatment regimensAzoxymethane-treated miceEffect of SJWNuclear factor kappa BBody weight lossWort extractTotal tumor volumeFactor kappa BSt. John's wort extractDose-dependent mannerAzoxymethane treatmentSJW administrationRectal bleedingOverall survivalTreatment regimensColorectal cancerProinflammatory processesTumor multiplicityLarge tumorsCholesterol levels