2023
Evaluating the PEN-FAST Clinical Decision-making Tool to Enhance Penicillin Allergy Delabeling
Su C, Belmont A, Liao J, Kuster J, Trubiano J, Kwah J. Evaluating the PEN-FAST Clinical Decision-making Tool to Enhance Penicillin Allergy Delabeling. JAMA Internal Medicine 2023, 183: 883-885. PMID: 37338869, PMCID: PMC10282954, DOI: 10.1001/jamainternmed.2023.1572.Peer-Reviewed Original ResearchA safe, effective, and single-day protocol for rapid drug desensitization to intravenous iron dextran
Belmont A, Liao J, Hsu F, Kwah J. A safe, effective, and single-day protocol for rapid drug desensitization to intravenous iron dextran. The Journal Of Allergy And Clinical Immunology In Practice 2023, 11: 3242-3244.e1. PMID: 37329952, DOI: 10.1016/j.jaip.2023.06.018.Peer-Reviewed Original ResearchAntibiotic choice for Group B Streptococcus prophylaxis in mothers with reported penicillin allergy and associated newborn outcomes
Snider J, Mithal L, Kwah J, Rhodes N, Son M. Antibiotic choice for Group B Streptococcus prophylaxis in mothers with reported penicillin allergy and associated newborn outcomes. BMC Pregnancy And Childbirth 2023, 23: 400. PMID: 37254067, PMCID: PMC10228028, DOI: 10.1186/s12884-023-05697-0.Peer-Reviewed Original ResearchConceptsGroup B streptococcus prophylaxisReported penicillin allergyPenicillin allergyGBS prophylaxisLab drawsNeonatal outcomesNewborn outcomesAntibiotic administrationMedical recordsPregnant individualsIntrapartum group B streptococcus prophylaxisNeonatal intensive care unit admissionDesignThis retrospective cohort studyIntensive care unit admissionSelf-reported penicillin allergyNeonates of mothersCare unit admissionIntrapartum antibiotic prophylaxisRetrospective cohort studyWeeks of gestationMother-infant pairsMother-infant dyadsBeta-lactam antibioticsAntibiotic prophylaxisUnit admissionCephalosporins can be safely administered to patients with verified penicillin allergy
Belmont A, Su C, Kwah J. Cephalosporins can be safely administered to patients with verified penicillin allergy. The Journal Of Allergy And Clinical Immunology In Practice 2023, 11: 2933-2935.e2. PMID: 37245737, DOI: 10.1016/j.jaip.2023.05.027.Peer-Reviewed Original ResearchDelayed Intradermal Skin Testing to Diagnose Culprits Drugs in Drug Reaction With Eosinophilia and Systemic Symptoms (DRESS)
Kwah J, Banerji A. Delayed Intradermal Skin Testing to Diagnose Culprits Drugs in Drug Reaction With Eosinophilia and Systemic Symptoms (DRESS). The Journal Of Allergy And Clinical Immunology In Practice 2023, 11: 1572-1573. PMID: 37150547, DOI: 10.1016/j.jaip.2023.02.013.Peer-Reviewed Case Reports and Technical Notes
2022
Clinical Phenotypes of Immediate First-Dose Reactions to mRNA COVID-19: A Multicenter Latent Class Analysis
Stone CA, Robinson LB, Li L, Krantz MS, Kwah JH, Ortega G, Mancini C, Wolfson AR, Saff RR, Samarakoon U, Hong DI, Koo G, Chow TG, Gruchalla R, Liao JX, Kuster JK, Price C, Ahola C, Khan DA, Phillips EJ, Banerji A, Blumenthal KG. Clinical Phenotypes of Immediate First-Dose Reactions to mRNA COVID-19: A Multicenter Latent Class Analysis. The Journal Of Allergy And Clinical Immunology In Practice 2022, 11: 458-465.e1. PMID: 36108922, PMCID: PMC9468049, DOI: 10.1016/j.jaip.2022.08.048.Peer-Reviewed Original ResearchConceptsMRNA COVID-19 vaccineNovel clinical phenotypesCOVID-19 vaccineDose 1Second doseClinical phenotypeObjective signsLatent class analysisMRNA coronavirus disease 2019 (COVID-19) vaccinesDose toleranceAllergy/immunology specialistsMRNA COVID-19 vaccinationCoronavirus disease 2019 (COVID-19) vaccinesSelf-limiting symptomsFirst-dose reactionsU.S. academic medical centersLog-binomial regressionCOVID-19 vaccinationDistinct clinical phenotypesAcademic medical centerImmediate reactionsImmunology specialistsClass analysisAllergic symptomsRetrospective studySurvey of Obstetric Providers to Assess the Knowledge and Management of a Reported Penicillin Allergy in Pregnant Women
Cate JJM, Burn M, Kwah J, Liao J, Illuzzi J, Reddy U, Son M. Survey of Obstetric Providers to Assess the Knowledge and Management of a Reported Penicillin Allergy in Pregnant Women. American Journal Of Perinatology 2022, 40: 001-008. PMID: 35709740, DOI: 10.1055/a-1877-9970.Peer-Reviewed Original ResearchConceptsPenicillin skin testingReported penicillin allergyPenicillin allergyObstetric providersPractice patternsEducational sessionsAllergy knowledgeProvider knowledgeEducational interventionSingle academic medical centerPenicillin allergy delabelingPenicillin allergy evaluationPenicillin allergy testingPercentage of patientsIdentification of patientsClinical practice patternsSmall group educational sessionsAcademic medical centerChi-square testAllergy evaluationPenicillin allergicPerinatal outcomesPregnant patientsDrug allergyAllergy testingDefining Clinical and Immunological Predictors of Poor Immune Responses to COVID-19 mRNA Vaccines in Patients with Primary Antibody Deficiency
Shin JJ, Par-Young J, Unlu S, McNamara A, Park HJ, Shin MS, Gee RJ, Doyle H, Afinogenova Y, Zidan E, Kwah J, Russo A, Mamula M, Hsu FI, Catanzaro J, Racke M, Bucala R, Wilen C, Kang I. Defining Clinical and Immunological Predictors of Poor Immune Responses to COVID-19 mRNA Vaccines in Patients with Primary Antibody Deficiency. Journal Of Clinical Immunology 2022, 42: 1137-1150. PMID: 35713752, PMCID: PMC9203263, DOI: 10.1007/s10875-022-01296-4.Peer-Reviewed Original ResearchMeSH KeywordsAntibodies, ViralCD8-Positive T-LymphocytesCommon Variable ImmunodeficiencyCOVID-19COVID-19 VaccinesHumansImmunity, CellularImmunoglobulin AImmunoglobulin GMRNA VaccinesPrimary Immunodeficiency DiseasesRNA, MessengerSARS-CoV-2Spike Glycoprotein, CoronavirusVaccinationVaccinesVaccines, SyntheticConceptsCommon variable immune deficiencyT cellsImmune responseIgG responsesCVID patientsMRNA vaccinesB cellsCoronavirus disease 2019 (COVID-19) mRNA vaccinesCOVID-19 mRNA vaccinesBaseline immune profileHistory of autoimmunityPrimary antibody deficiencyT cell responsesCellular immune responsesPoor immune responseVariable immune deficiencyMemory B cellsSARS-CoV-2 spike proteinBaseline IgGCVID diagnosisEM CD8Immunological predictorsPAD cohortSpecific CD4Immune profileOutpatient penicillin allergy evaluation during pregnancy and associated clinical outcomes
Kwah JH, Burn MS, Liao J, Cate J, Son M. Outpatient penicillin allergy evaluation during pregnancy and associated clinical outcomes. American Journal Of Obstetrics & Gynecology MFM 2022, 4: 100674. PMID: 35691578, DOI: 10.1016/j.ajogmf.2022.100674.Peer-Reviewed Original ResearchConceptsPenicillin allergy evaluationPenicillin allergyPregnant womenAllergy evaluationHospital stayNeonatal outcomesClinical benefitIntensive care unit admissionBirth hospitalization lengthUnverified penicillin allergyCare unit admissionNeonatal adverse outcomesRetrospective cohort studyMedical record reviewPostpartum hospital stayAdditional clinical benefitLarge academic hospitalElectronic medical recordsBeta-lactam antibioticsPostpartum infectionReferred womenUnit admissionMaternal outcomesCohort studyTrue allergy
2021
Safety Evaluation of the Second Dose of Messenger RNA COVID-19 Vaccines in Patients With Immediate Reactions to the First Dose
Krantz MS, Kwah JH, Stone CA, Phillips EJ, Ortega G, Banerji A, Blumenthal KG. Safety Evaluation of the Second Dose of Messenger RNA COVID-19 Vaccines in Patients With Immediate Reactions to the First Dose. JAMA Internal Medicine 2021, 181: 1530-1533. PMID: 34309623, PMCID: PMC8314170, DOI: 10.1001/jamainternmed.2021.3779.Peer-Reviewed Original Research
2020
Clinical factors associated with acute exacerbations of chronic rhinosinusitis
Kwah JH, Somani SN, Stevens WW, Kern RC, Smith SS, Welch KC, Conley DB, Tan BK, Grammer LC, Yang A, Schleimer RP, Peters AT. Clinical factors associated with acute exacerbations of chronic rhinosinusitis. Journal Of Allergy And Clinical Immunology 2020, 145: 1598-1605. PMID: 32004523, PMCID: PMC8177481, DOI: 10.1016/j.jaci.2020.01.023.Peer-Reviewed Original ResearchConceptsFrequent acute exacerbationsChronic rhinosinusitisAcute exacerbationAllergic rhinitisClinical factorsEosinophil countAutoimmune diseasesSignificant health care burdenSinus disease severityRetrospective cohort studySystemic corticosteroid useHealth care burdenHigh-risk phenotypeAntibiotic allergyExacerbation frequencyFrequent exacerbationsSinus symptomsCorticosteroid useCohort studyLower FEVNasal polyposisAntibody deficiencyImpaired qualityImmunologic diseasesOdds ratio
2019
Nasal polyps and rhinosinusitis.
Kwah JH, Peters AT. Nasal polyps and rhinosinusitis. Allergy & Asthma Proceedings 2019, 40: 380-384. PMID: 31690375, DOI: 10.2500/aap.2019.40.4252.Peer-Reviewed Original ResearchConceptsAspirin-exacerbated respiratory diseaseChronic rhinosinusitisNasal polypsNasal congestionEthmoid sinusSinus cavityCiliated columnar epithelial cellsPolyp sizeAcute sinus infectionsTopical nasal steroidsAnterior ethmoid sinusChronic mucosal inflammationAllergic fungal rhinosinusitisMajority of patientsTreatment of choiceParanasal sinus mucosaPosterior ethmoid sinusColumnar epithelial cellsAspirin desensitizationIntranasal corticosteroidsNasal steroidsOral steroidsAcute rhinosinusitisMaintenance therapyPersistent asthmaAsthma in adults: Principles of treatment.
Kwah JH, Peters AT. Asthma in adults: Principles of treatment. Allergy & Asthma Proceedings 2019, 40: 396-402. PMID: 31690379, DOI: 10.2500/aap.2019.40.4256.Peer-Reviewed Original ResearchConceptsAllergen immunotherapyAllergic asthmaBetter long-term controlModerate allergic asthmaT2-high asthmaType 2 inflammationGastroesophageal reflux diseasePrevention of exacerbationsAllergen-specific immunotherapyEmergency department visitsPhysical examination findingsExpiratory flow rateGoal of treatmentPrinciples of treatmentReduction of symptomsSeverity of symptomsNormal activity levelsLong-term controlReflux diseaseSevere asthmaAllergic rhinitisAsthma symptomsBiologic therapyPulmonary functionSelect patientsAsthma and allergies in pregnancy.
Kwah JH, Stevens WW. Asthma and allergies in pregnancy. Allergy & Asthma Proceedings 2019, 40: 414-417. PMID: 31690383, PMCID: PMC8242985, DOI: 10.2500/aap.2019.40.4260.Peer-Reviewed Original ResearchConceptsMedical therapyStandard medical therapyNormal physiologic changesCommon respiratory diseasesCourse of asthmaBenefits of medicationsEvaluation of symptomsUncontrolled asthmaAllergic rhinitisPulmonary functionVasomotor rhinitisComorbid conditionsPregnant womenPhysiologic changesPatient educationRespiratory diseaseAsthmaGeneral populationMost womenPregnancyAppropriate managementEnvironmental exposuresRhinitisTherapyRiskPrevalence and characterization of chronic rhinosinusitis in patients with non‒cystic fibrosis bronchiectasis at a tertiary care center in the United States
Somani SN, Kwah JH, Yeh C, Conley DB, Grammer LC, Kern RC, Prickett M, Schleimer RP, Smith SS, Stevens WW, Tan BK, Welch KC, Peters AT. Prevalence and characterization of chronic rhinosinusitis in patients with non‒cystic fibrosis bronchiectasis at a tertiary care center in the United States. International Forum Of Allergy & Rhinology 2019, 9: 1424-1429. PMID: 31589811, PMCID: PMC6913921, DOI: 10.1002/alr.22436.Peer-Reviewed Original ResearchConceptsPresence of CRSTertiary care centerChronic rhinosinusitisCare centerNon-cystic fibrosis bronchiectasisPrevalence of CRSConcomitant chronic rhinosinusitisRetrospective cohort studyGastroesophageal reflux diseasePeripheral eosinophil countPulmonary function testingTertiary medical centerNumerous comorbid conditionsTreatment of patientsUnited States populationBronchiectasis patientsFibrosis bronchiectasisReflux diseaseAllergic rhinitisCohort studyRadiographic evidenceAntibody deficiencyComorbid conditionsEosinophil countFunction testing