2018
Corticotrophin releasing factor receptor 1 antagonists prevent chronic stress-induced behavioral changes and synapse loss in aged rats
Dong H, Keegan JM, Hong E, Gallardo C, Montalvo-Ortiz J, Wang B, Rice KC, Csernansky J. Corticotrophin releasing factor receptor 1 antagonists prevent chronic stress-induced behavioral changes and synapse loss in aged rats. Psychoneuroendocrinology 2018, 90: 92-101. PMID: 29477954, PMCID: PMC5864558, DOI: 10.1016/j.psyneuen.2018.02.013.Peer-Reviewed Original ResearchMeSH KeywordsAge FactorsAnimalsAnxietyBehaviorBehavior, AnimalCorticotropin-Releasing HormoneDepressionDisease Models, AnimalFemaleHypothalamo-Hypophyseal SystemMalePituitary-Adrenal SystemPyrimidinesPyrrolesRatsRats, Sprague-DawleyReceptors, Corticotropin-Releasing HormoneStress, PsychologicalSynapsesConceptsStress-induced behavioral changesStress-induced anxietyAnxiety-related behaviorMemory deficitsChronic stressSynapse lossCRF1 antagonistsFactor receptor 1 antagonistCortical dendritic spinesHPA axis dysfunctionBody weight lossReceptor 1 antagonistMonths of ageSubset of animalsBehavioral changesFactor receptor 1Axis dysfunctionAged brainAged ratsPotential therapyDendritic spinesAnimal modelsCorticosterone levelsAlzheimer's diseaseReceptor 1
2014
Effects of corticotrophin-releasing factor receptor 1 antagonists on amyloid-β and behavior in Tg2576 mice
Dong H, Wang S, Zeng Z, Li F, Montalvo-Ortiz J, Tucker C, Akhtar S, Shi J, Meltzer HY, Rice KC, Csernansky JG. Effects of corticotrophin-releasing factor receptor 1 antagonists on amyloid-β and behavior in Tg2576 mice. Psychopharmacology 2014, 231: 4711-4722. PMID: 24862368, PMCID: PMC4233002, DOI: 10.1007/s00213-014-3629-8.Peer-Reviewed Original ResearchMeSH KeywordsAlzheimer DiseaseAmyloid beta-Protein PrecursorAnimalsCorticotropin-Releasing HormoneCyclic AMPCyclic AMP-Dependent Protein KinasesDisease Models, AnimalHippocampusMaleMemoryMiceMice, TransgenicNeuronsPlaque, AmyloidPyrimidinesPyrrolesReceptors, Corticotropin-Releasing HormoneSignal TransductionConceptsAβ1-42 levelsCorticotrophin-releasing factorReceptor 1 antagonistPlaque depositionCRF1 antagonistsMouse modelDays of ageAlzheimer's diseaseMouse pupsIsolation stressCRF receptor 1 antagonistFactor receptor 1 antagonistAdministration of antalarminExogenous CRF administrationCultured primary hippocampal neuronsDaily intraperitoneal injectionsIncubation of neuronsCohort of micePlasma corticosterone levelsPrimary hippocampal neuronsMonths of ageCRF administrationAβ levelsIntraperitoneal injectionHippocampal neurons