2015
Early Life Stress as a Risk Factor for Substance use Disorders: Clinical and Neurobiological Substrates
Varghese SP, Montalvo-Ortiz JL, Csernansky JG, Eiger RI, Herrold AA, Koola MM, Dong H. Early Life Stress as a Risk Factor for Substance use Disorders: Clinical and Neurobiological Substrates. Indian Journal Of Psychological Medicine 2015, 37: 36-41. PMID: 25722510, PMCID: PMC4341308, DOI: 10.4103/0253-7176.150816.Peer-Reviewed Original ResearchEarly life stressWithdrawal symptomsMorphine administrationMorphine sensitizationWT miceCRF-OEOpiate withdrawal symptomsDoses of morphineCRF-OE miceEffects of ELSLife stressWild-type miceSubstance use disordersCRF miceRisk factorsImmunohistochemistry studiesNucleus accumbensType miceImmunohistochemistry analysisUse disordersMorphineBehavioral trialsSymptomsMiceElevated levels
2013
HDAC Inhibitors Restore the Capacity of Aged Mice to Respond to Haloperidol through Modulation of Histone Acetylation
Montalvo-Ortiz JL, Keegan J, Gallardo C, Gerst N, Tetsuka K, Tucker C, Matsumoto M, Fang D, Csernansky JG, Dong H. HDAC Inhibitors Restore the Capacity of Aged Mice to Respond to Haloperidol through Modulation of Histone Acetylation. Neuropsychopharmacology 2013, 39: 1469-1478. PMID: 24366052, PMCID: PMC3988551, DOI: 10.1038/npp.2013.346.Peer-Reviewed Original ResearchConceptsC-fos expressionAged miceValproic acidNucleus accumbensPrefrontal cortexYoung miceMS-275HDAC inhibitorsC-Fos expression patternHDAC inhibitor valproic acidAntipsychotic drug actionEffects of haloperidolAge-related decreaseInhibitor valproic acidHistone deacetylase inhibitorsElderly patientsHAL administrationHistone acetylationAntipsychotic drugsAvoidance responseBehavioral disturbancesElderly individualsClinical experienceHaloperidolEpigenetic changes