2023
Naltrexone/bupropion for binge‐eating disorder: A randomized, double‐blind, placebo‐controlled trial
Grilo C, Lydecker J, Jastreboff A, Pittman B, McKee S. Naltrexone/bupropion for binge‐eating disorder: A randomized, double‐blind, placebo‐controlled trial. Obesity 2023, 31: 2762-2773. PMID: 37751990, PMCID: PMC10600891, DOI: 10.1002/oby.23898.Peer-Reviewed Original ResearchConceptsNaltrexone/bupropionBinge-eating disorderObesity statusLogistic regressionWeight lossPlacebo-controlled trialWeight loss outcomesPrevalent psychiatric disordersEvidence-based treatmentsPost-treatment assessmentBinge-eating frequencyGreater percentage weight lossMedication outcomesRemission ratePharmacological optionsPlaceboBupropionPsychiatric disordersPercentage weight lossMixed modelsDisordersObesityPatientsSignificant reductionWeight reductionNaltrexone plus bupropion combination medication maintenance treatment for binge-eating disorder following successful acute treatments: randomized double-blind placebo-controlled trial
Grilo C, Lydecker J, Gueorguieva R. Naltrexone plus bupropion combination medication maintenance treatment for binge-eating disorder following successful acute treatments: randomized double-blind placebo-controlled trial. Psychological Medicine 2023, 53: 7775-7784. PMID: 37366017, PMCID: PMC10751383, DOI: 10.1017/s0033291723001800.Peer-Reviewed Original ResearchConceptsNaltrexone/bupropionBinge-eating disorderBinge-eating remissionAcute treatmentMaintenance treatmentBinge-eating frequencyDouble-blind placebo-controlled trialBehavioral weight loss therapyWeight lossCo-occurring obesitySuccessful acute treatmentPlacebo-controlled trialWeight loss therapySignificant additional weight lossSingle-site trialAdditional weight lossAcute efficacyRemission rateAdult patientsComorbid obesityBupropionInitial interventionPosttreatment assessmentRespondersPlacebo
2022
Naltrexone-Bupropion and Behavior Therapy, Alone and Combined, for Binge-Eating Disorder: Randomized Double-Blind Placebo-Controlled Trial
Grilo CM, Lydecker JA, Fineberg SK, Moreno JO, Ivezaj V, Gueorguieva R. Naltrexone-Bupropion and Behavior Therapy, Alone and Combined, for Binge-Eating Disorder: Randomized Double-Blind Placebo-Controlled Trial. American Journal Of Psychiatry 2022, 179: 927-937. PMID: 36285406, PMCID: PMC9722598, DOI: 10.1176/appi.ajp.20220267.Peer-Reviewed Original ResearchConceptsBehavioral weight loss therapyBinge-eating disorderPlacebo groupBupropion groupWeight lossRandomized double-blind placebo-controlled trialDouble-blind placebo-controlled trialLogistic regressionBinge-eating remissionPlacebo-controlled trialWeight loss therapyDouble-blind placeboSerious public health problemPublic health problemEvidence-based treatmentsRate of participantsBinge-eating frequencyBinge Eating DisorderMedical comorbiditiesRemission rateLoss therapyPercent weight lossMixed modelsFunctional impairmentSecondary measures
2021
Physical activity changes during behavioral weight loss treatment by Latinx patients with obesity with and without binge eating disorder
Grilo CM, Kerrigan SG, Lydecker JA, White MA. Physical activity changes during behavioral weight loss treatment by Latinx patients with obesity with and without binge eating disorder. Obesity 2021, 29: 2026-2034. PMID: 34582624, PMCID: PMC8612949, DOI: 10.1002/oby.23278.Peer-Reviewed Original ResearchMeSH KeywordsBinge-Eating DisorderCognitive Behavioral TherapyExerciseHumansObesityTreatment OutcomeWeight LossConceptsBehavioral weight loss treatmentWeight loss treatmentLatinx patientsPhysical activity changesBWL treatmentReduced depressionCommunity mental health centerWeight lossPA changePlacebo-controlled trialAddition of orlistatMental health centersActivity changesPrognostic significanceMedication conditionHealth centersLoss treatmentPatientsObesitySecondary analysisClinical settingBed statusBaselineTreatmentDepressionExamination of night eating and loss-of-control eating following bariatric surgery
Ivezaj V, Lawson JL, Lydecker JA, Duffy AJ, Grilo CM. Examination of night eating and loss-of-control eating following bariatric surgery. Eating And Weight Disorders - Studies On Anorexia, Bulimia And Obesity 2021, 27: 207-213. PMID: 33730344, PMCID: PMC8925302, DOI: 10.1007/s40519-021-01156-x.Peer-Reviewed Original ResearchConceptsPittsburgh Sleep Quality IndexNight Eating QuestionnaireNight-eating syndromeBariatric surgeryNight eatingSleeve gastrectomyPoor post-operative outcomesPercent total weight lossPost-bariatric patientsPost-operative outcomesLong-term outcomesNegative prognostic indicatorSleep Quality IndexEating Disorder Examination interviewEating-disorder psychopathologyNight-eating behaviorsBeck Depression InventoryClinical featuresPSQI scoresPrognostic indicatorPoor sleepSevere subgroupBDI-IIDepression InventoryTotal weight loss
2020
Internalized weight bias and loss-of-control eating following bariatric surgery
Lawson JL, LeCates A, Ivezaj V, Lydecker J, Grilo CM. Internalized weight bias and loss-of-control eating following bariatric surgery. Eating Disorders 2020, 29: 630-643. PMID: 32182194, PMCID: PMC7494529, DOI: 10.1080/10640266.2020.1731920.Peer-Reviewed Original ResearchMeSH KeywordsAdultBariatric SurgeryFeeding and Eating DisordersGastrectomyHumansQuality of LifeWeight LossConceptsEating Disorder Examination-Bariatric Surgery Version interviewEating-disorder psychopathologyBariatric surgeryWeight biasGreater eating-disorder psychopathologyPercent excess weight lossEating Disorder FeaturesInternalized weight biasExcess weight lossHierarchical regression analysisControl eatingPsychosocial difficultiesGastrectomy patientsAdult patientsClinical presentationGastrectomy surgeryPrognostic significanceWeight concernsClinical correlatesEstablished measuresNon-White participantsSurgeryPatientsPsychopathologyMental qualityTesting the Validity and Clinical Utility of the Severity Specifiers for Binge-Eating Disorder for Predicting Treatment Outcomes
Lydecker JA, Ivezaj V, Grilo CM. Testing the Validity and Clinical Utility of the Severity Specifiers for Binge-Eating Disorder for Predicting Treatment Outcomes. Journal Of Consulting And Clinical Psychology 2020, 88: 172-178. PMID: 31894997, PMCID: PMC7286612, DOI: 10.1037/ccp0000464.Peer-Reviewed Original ResearchConceptsBinge-eating disorderCognitive behavioral therapyBehavioral weight lossSeverity specifiersSelf-report measuresTreatment-seeking individualsBinge-eating frequencyBinge Eating DisorderEating-disorder psychopathologyClinical utilityTreatment outcomesSeverity categoriesPredicting Treatment OutcomeWeight lossFuture researchMain effectDepression scoresStatistical ManualParticipantsTesting treatmentsMultimodal treatmentPharmacological treatmentTreatment responseMedical CenterLarge series
2019
Getting a head start: identifying pretreatment correlates associated with early weight loss for individuals participating in weight loss treatment
Wiedemann AA, Baumgardt SS, Ivezaj V, Kerrigan SG, Lydecker JA, Grilo CM, Barnes RD. Getting a head start: identifying pretreatment correlates associated with early weight loss for individuals participating in weight loss treatment. Translational Behavioral Medicine 2019, 11: 236-243. PMID: 31816053, PMCID: PMC7877303, DOI: 10.1093/tbm/ibz149.Peer-Reviewed Original ResearchConceptsEarly weight lossWeight loss treatmentUsual careWeight lossLow pretreatmentDepressive symptomsWeek sixMeaningful weight lossPrimary care settingBinge-eating disorder diagnosisEating Disorder Examination interviewGreater weight lossNutrition psychoeducationTreatment cessationPercent weight lossPrimary careNPC groupObesity rangeLoss treatmentEmotional overeatingExamination interviewDisorder diagnosisPretreatment correlatesMotivational interviewingTreatmentRacial Comparisons of Postoperative Weight Loss and Eating‐Disorder Psychopathology Among Patients Following Sleeve Gastrectomy Surgery
Ivezaj V, Fu E, Lydecker JA, Duffy AJ, Grilo CM. Racial Comparisons of Postoperative Weight Loss and Eating‐Disorder Psychopathology Among Patients Following Sleeve Gastrectomy Surgery. Obesity 2019, 27: 740-745. PMID: 30925196, PMCID: PMC6478551, DOI: 10.1002/oby.22446.Peer-Reviewed Original ResearchConceptsSleeve gastrectomy surgeryEating-disorder psychopathologyWhite patientsBlack patientsGastrectomy surgeryWeight lossEating Disorder Examination-Bariatric Surgery VersionMedical Outcomes Study Short-Form Health SurveyPercent excess weight lossPercent total weight lossMental health-related qualityShort Form Health SurveyPsychosocial functioningExcess weight lossPostoperative weight lossHealth-related qualityBeck Depression Inventory-IIRacial differencesBinge-eating disorderPresurgical BMISleeve gastrectomyLess weight lossEating Disorder PsychopathologyHealth SurveyMeal patterns
2017
Characteristics of Weight Loss Trajectories in a Comprehensive Lifestyle Intervention
Marek RJ, Coulon SM, Brown JD, Lydecker JA, Marek S, Malcolm R, O'Neil PM. Characteristics of Weight Loss Trajectories in a Comprehensive Lifestyle Intervention. Obesity 2017, 25: 2062-2067. PMID: 29086487, DOI: 10.1002/oby.21942.Peer-Reviewed Original ResearchConceptsWeight loss trajectoriesAverage weight lossWeight lossLifestyle interventionWeight changeWeight gainComprehensive lifestyle interventionLatent class analysisMeal replacement dietMore tailored interventionsLifestyle change counselingWeekly weight changesWeekly weight gainPercent weight lossLess optimal outcomesLifestyle programEfficacy dataGroup 2Group 1Group 3Class analysisPatientsTailored interventionsOptimal outcomesPercent weight gain
2016
Loss-of-control eating following sleeve gastrectomy surgery
Ivezaj V, Kessler EE, Lydecker JA, Barnes RD, White MA, Grilo CM. Loss-of-control eating following sleeve gastrectomy surgery. Surgery For Obesity And Related Diseases 2016, 13: 392-398. PMID: 27913121, PMCID: PMC5357454, DOI: 10.1016/j.soard.2016.09.028.Peer-Reviewed Original ResearchConceptsSleeve gastrectomy surgeryGastrectomy surgeryWeight lossEating Disorder Examination-Bariatric Surgery VersionPoorer weight loss outcomesBED criteriaLower percent weight lossPoor weight lossWeight loss outcomesBody mass indexEating-disorder psychopathologyBinge-eating disorderRegular compensatory behaviorsCurrent mean ageUnited States METHODSBariatric surgeryPostoperative lossMass indexPercent weight lossMean ageMonths postsurgeryPoor outcomeLoss outcomesGreater severitySurgery