Featured Publications
Reward-Mediated, Model-Free Reinforcement-Learning Mechanisms in Pavlovian and Instrumental Tasks Are Related
Afshar N, Cinotti F, Martin D, Khamassi M, Calu DJ, Taylor JR, Groman SM. Reward-Mediated, Model-Free Reinforcement-Learning Mechanisms in Pavlovian and Instrumental Tasks Are Related. Journal Of Neuroscience 2022, 43: 458-471. PMID: 36216504, PMCID: PMC9864557, DOI: 10.1523/jneurosci.1113-22.2022.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsConditioning, OperantCuesLearningMaleMotivationRatsReinforcement, PsychologyRewardConceptsGoal-tracking behaviorReinforcement learning mechanismInstrumental learning processesSign-tracking behaviorModel-free reinforcementApproach taskInstrumental taskInstrumental behaviorBehavioral proceduresSubjects designLearning mechanismDecision Making TaskModel-based computationLearning processModel-free reinforcement learningPredictive cuesIncentive salienceAssociative learningIndividual differencesComputational mechanismsDecision-making processPavlovianModel-based algorithmValue representationAction valuesReinforcement Learning during Adolescence in Rats
Afshar N, Keip AJ, Taylor JR, Lee D, Groman SM. Reinforcement Learning during Adolescence in Rats. Journal Of Neuroscience 2020, 40: 5857-5870. PMID: 32601244, PMCID: PMC7380962, DOI: 10.1523/jneurosci.0910-20.2020.Peer-Reviewed Original ResearchMeSH KeywordsAge FactorsAnimalsConditioning, OperantFemaleHumansMaleRatsRats, Long-EvansReinforcement, PsychologyReversal LearningConceptsNovel behavioral protocolReversal-learning performanceAdaptive choice behaviorBehavioral protocolFemale Long-Evans ratsReversal performanceChoice behaviorLong-Evans ratsAdolescent brain functionAge-related improvementsReinforcement-learning mechanismsReversal-learning taskReversal-learning paradigmDecision-making paradigmReinforcement learning mechanismAdolescent ratsLongitudinal designAge-related changesNeurodevelopmental mechanismsAdolescencePositive outcomesBrain functionFunction of circuitsPostnatal day 30Adulthood
2012
The tyrosine phosphatase STEP constrains amygdala-dependent memory formation and neuroplasticity
Olausson P, Venkitaramani D, Moran T, Salter M, Taylor J, Lombroso P. The tyrosine phosphatase STEP constrains amygdala-dependent memory formation and neuroplasticity. Neuroscience 2012, 225: 1-8. PMID: 22885232, PMCID: PMC3725644, DOI: 10.1016/j.neuroscience.2012.07.069.Peer-Reviewed Original ResearchMeSH KeywordsAmygdalaAnalysis of VarianceAnimalsBiophysicsConditioning, OperantElectric StimulationExcitatory Postsynaptic PotentialsFearMaleMAP Kinase Signaling SystemMemoryMiceMice, Inbred C57BLMice, TransgenicNeuronal PlasticityPatch-Clamp TechniquesProtein Tyrosine Phosphatases, Non-ReceptorReinforcement ScheduleReinforcement, PsychologyConceptsSynaptic plasticityExperience-dependent synaptic plasticityAspartic acid (NMDA) receptorsMemory formationLong-term potentiationAdult neuroplasticityAmygdala-dependent memory formationPharmacological treatmentKO miceExperience-induced neuroplasticityTyrosine phosphatase STEPNR2B subunitLateral amygdalaBrain regionsTyrosine kinase FynAcid receptorsStriatal-enriched protein tyrosine phosphataseNeuroplasticityMiceERK phosphorylationReceptor internalizationERK signalingKinase 1/2Detectable expressionSTEP KO mice
2009
Prior chronic cocaine exposure in mice induces persistent alterations in cognitive function
Krueger DD, Howell JL, Oo H, Olausson P, Taylor JR, Nairn AC. Prior chronic cocaine exposure in mice induces persistent alterations in cognitive function. Behavioural Pharmacology 2009, 20: 695-704. PMID: 19901826, PMCID: PMC3380449, DOI: 10.1097/fbp.0b013e328333a2bb.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsAttentionCocaineCocaine-Related DisordersCognitionConditioning, ClassicalConditioning, OperantDisease Models, AnimalImpulsive BehaviorInhibition, PsychologicalInjections, IntraperitonealMaleMemory DisordersMemory, Short-TermMiceMice, Inbred C57BLMotor ActivityReinforcement ScheduleReinforcement, PsychologyReversal LearningTime FactorsConceptsCognitive functionAttentional functionsResponse inhibitionPrefrontal cortexThree-choice serial reaction time taskSerial reaction time taskReaction time taskPattern of errorsCocaine exposureDevelopment of addictionPrior chronic exposureCognitive flexibilityInstrumental reversalTime taskPosition taskChronic cocaine exposureChronic cocaine useCognitive dysfunctionTaskMemoryCocaine useDrug-free periodSuitable animal modelMultiple aspectsCortexPrelimbic cortex bdnf knock-down reduces instrumental responding in extinction
Gourley SL, Howell JL, Rios M, DiLeone RJ, Taylor JR. Prelimbic cortex bdnf knock-down reduces instrumental responding in extinction. Learning & Memory 2009, 16: 756-760. PMID: 19926781, PMCID: PMC2788209, DOI: 10.1101/lm.1547909.Peer-Reviewed Original ResearchNeuronal Correlates of Instrumental Learning in the Dorsal Striatum
Kimchi EY, Torregrossa MM, Taylor JR, Laubach M. Neuronal Correlates of Instrumental Learning in the Dorsal Striatum. Journal Of Neurophysiology 2009, 102: 475-489. PMID: 19439679, PMCID: PMC2712266, DOI: 10.1152/jn.00262.2009.Peer-Reviewed Original ResearchConceptsDorsal striatumResponse portsNeuronal activityTask-related firingTask-related neuronsMovement-related potentialsInitiation of movementLateral striatumLearning-related changesMedial striatumStriatumNeuronal correlatesReward portNumber of neuronsAcoustic stimuliNeuronsOperant taskField potentialsProgressive increaseLateral regionsTheta-band oscillationsHigh rateTraining periodInstrumental learningHead entries
2008
Corticosterone Regulates pERK1/2 Map Kinase in a Chronic Depression Model
Gourley SL, Wu FJ, Taylor JR. Corticosterone Regulates pERK1/2 Map Kinase in a Chronic Depression Model. Annals Of The New York Academy Of Sciences 2008, 1148: 509-514. PMID: 19120149, PMCID: PMC3657205, DOI: 10.1196/annals.1410.076.Peer-Reviewed Original ResearchConceptsDepression modelCA1/CA3Chronic depression modelPrefrontal cortical targetsExtracellular signal-regulated kinase 1/2Signal-regulated kinase 1/2Antidepressant efficacyDentate gyrusCorticosterone exposureCortical targetsReceptor typesKinase 1/2Motivated behaviorNovel roleIntracellular signalingPERK1/2MAP kinaseTranscriptional activityNeurotrophinsHippocampusCorticosteroneCA3GyrusMiceInsultTargeting extinction and reconsolidation mechanisms to combat the impact of drug cues on addiction
Taylor JR, Olausson P, Quinn JJ, Torregrossa MM. Targeting extinction and reconsolidation mechanisms to combat the impact of drug cues on addiction. Neuropharmacology 2008, 56: 186-195. PMID: 18708077, PMCID: PMC2635342, DOI: 10.1016/j.neuropharm.2008.07.027.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsConditioning, OperantCuesExtinction, PsychologicalHumansSelf AdministrationSubstance-Related DisordersConceptsCue-drug memoriesCue-drug associationsCue exposure therapyMemory reconsolidation processesDisruption of reconsolidationCue-induced relapseDrug-associated cuesInhibitory memoryReconsolidation mechanismsDrug cuesMemory retrievalReconsolidation processMemory processesReconsolidationCompulsive disorderRelapse behaviorMemoryMemory erasureBrief time periodDrug addictionDistinct processesCuesAddictionExtinctionCraving
2007
Regionally Specific Regulation of ERK MAP Kinase in a Model of Antidepressant-Sensitive Chronic Depression
Gourley SL, Wu FJ, Kiraly DD, Ploski JE, Kedves AT, Duman RS, Taylor JR. Regionally Specific Regulation of ERK MAP Kinase in a Model of Antidepressant-Sensitive Chronic Depression. Biological Psychiatry 2007, 63: 353-359. PMID: 17889834, PMCID: PMC2277331, DOI: 10.1016/j.biopsych.2007.07.016.Peer-Reviewed Original ResearchMeSH KeywordsAmitriptylineAnimalsAntidepressive Agents, TricyclicAnti-Inflammatory AgentsChronic DiseaseConditioning, OperantCorticosteroneCREB-Binding ProteinDentate GyrusDepressive Disorder, MajorDisease Models, AnimalEndoplasmic Reticulum Chaperone BiPExtracellular Signal-Regulated MAP KinasesFluoxetineHeat-Shock ProteinsHippocampusLocomotionMiceMice, Inbred C57BLMolecular ChaperonesMotivationSelective Serotonin Reuptake InhibitorsConceptsAntidepressant efficacyChronic corticosteroneDentate gyrusChronic depressionCA1/CA3Depression-like behaviorExtracellular signal-regulated kinase 1/2Response element-binding proteinSignal-regulated kinase 1/2Amitriptyline treatmentGlucocorticoid exposureADT treatmentNaive rodentsBehavioral despairLong-term consequencesTail suspensionElement-binding proteinCyclic adenosine monophosphateBiochemical measuresERK MAP kinasePrefrontal cortexHeat shock proteinsOperant conditioning taskCommon mediatorPERK1/2
2000
Object retrieval/detour deficits in monkeys produced by prior subchronic phencyclidine administration: evidence for cognitive impulsivity
Jentsch J, Roth R, Taylor J. Object retrieval/detour deficits in monkeys produced by prior subchronic phencyclidine administration: evidence for cognitive impulsivity. Biological Psychiatry 2000, 48: 415-424. PMID: 10978725, DOI: 10.1016/s0006-3223(00)00926-4.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsChlorocebus aethiopsCognitionConditioning, OperantFemaleHallucinogensImpulsive BehaviorMaleMental RecallPhencyclidineConceptsPhencyclidine administrationObject retrieval detour taskFrontal cortical dysfunctionFrontal cortex ablationSubchronic phencyclidine administrationPerformance of trialsDrugs of abusePhencyclidine exposureSubchronic administrationIntermittent administrationCortical dysfunctionDrug withdrawalChronic consumptionDopaminergic dysfunctionBehavioral deficitsPsychotomimetic drugsCorticostriatal functionInhibitory response controlCognitive impairmentImpaired acquisitionNonhuman primatesAdministrationPhencyclidineDysfunctionInhibitory control
1999
Enhancement of Locomotor Activity and Conditioned Reward to Cocaine by Brain-Derived Neurotrophic Factor
Horger B, Iyasere C, Berhow M, Messer C, Nestler E, Taylor J. Enhancement of Locomotor Activity and Conditioned Reward to Cocaine by Brain-Derived Neurotrophic Factor. Journal Of Neuroscience 1999, 19: 4110-4122. PMID: 10234039, PMCID: PMC6782687, DOI: 10.1523/jneurosci.19-10-04110.1999.Peer-Reviewed Original ResearchConceptsBrain-derived neurotrophic factorDevelopment of sensitizationLocomotor sensitizationBDNF infusionNeurotrophic factorNucleus accumbensStimulant effectsInitial stimulant effectMesolimbic DA systemCocaine-induced locomotionVentral tegmental areaMesolimbic dopamine systemWild-type littermatesPsychomotor stimulant effectsBDNF administrationDopaminergic neuronsTegmental areaCocaine injectionCocaine dosesControl animalsDopamine systemLocomotor activityDrug rewardCR leverDA system
1991
Potentiation of the effects of reward-related stimuli by dopaminergic-dependent mechanisms in the nucleus accumbens
Cador M, Taylor J, Robbins T. Potentiation of the effects of reward-related stimuli by dopaminergic-dependent mechanisms in the nucleus accumbens. Psychopharmacology 1991, 104: 377-385. PMID: 1924645, DOI: 10.1007/bf02246039.Peer-Reviewed Original ResearchConceptsDorsal noradrenergic bundleDose-dependent increaseDA-dependent mechanismSignificant dose-dependent increaseSmaller infusion volumesDA infusionDA receptorsAlpha-flupenthixolNoradrenergic bundleSystemic doseProfound depletionNucleus accumbensReward-related processesInfusion volumeNeurotoxic lesionsNA levelsNeurochemical mediationNoradrenalinePotentiationCONDITIONED REINFORCEMENTDopamineReward-related stimuliConditioned reinforcersAmphetamineDoses
1986
6-Hydroxydopamine lesions of the nucleus accumbens, but not of the caudate nucleus, attenuate enhanced responding with reward-related stimuli produced by intra-accumbens d-amphetamine
Taylor J, Robbins T. 6-Hydroxydopamine lesions of the nucleus accumbens, but not of the caudate nucleus, attenuate enhanced responding with reward-related stimuli produced by intra-accumbens d-amphetamine. Psychopharmacology 1986, 90: 390-397. PMID: 3097729, DOI: 10.1007/bf00179197.Peer-Reviewed Original Research
1984
Enhanced behavioural control by conditioned reinforcers following microinjections of d-amphetamine into the nucleus accumbens
Taylor J, Robbins T. Enhanced behavioural control by conditioned reinforcers following microinjections of d-amphetamine into the nucleus accumbens. Psychopharmacology 1984, 84: 405-412. PMID: 6440188, DOI: 10.1007/bf00555222.Peer-Reviewed Original Research