1998
A comparison of the effects of clonidine and CNQX infusion into the locus coeruleus and the amygdala on naloxone-precipitated opiate withdrawal in the rat
Taylor J, Punch L, Elsworth J. A comparison of the effects of clonidine and CNQX infusion into the locus coeruleus and the amygdala on naloxone-precipitated opiate withdrawal in the rat. Psychopharmacology 1998, 138: 133-142. PMID: 9718282, DOI: 10.1007/s002130050655.Peer-Reviewed Original Research
1997
Dysregulation of Mesoprefrontal Dopamine Neurons Induced by Acute and Repeated Phencyclidine Administration in the Nonhuman Primate: Implications for Schizophrenia
Jentsch J, Elsworth J, Taylor J, Redmond D, Roth R. Dysregulation of Mesoprefrontal Dopamine Neurons Induced by Acute and Repeated Phencyclidine Administration in the Nonhuman Primate: Implications for Schizophrenia. Advances In Pharmacology 1997, 42: 810-814. PMID: 9328021, DOI: 10.1016/s1054-3589(08)60870-4.Peer-Reviewed Original ResearchConceptsPCP administrationAcute PCP administrationNegative symptomsDA systemMesoprefrontal dopamine neuronsSubcortical DA systemsBrains of patientsSchizophrenia-like symptomatologyDevelopment of neuropathologyDistinct behavioral effectsDAergic dysfunctionDA metabolismDAergic functionDopamine neuronsCognitive dysfunctionNovel agentsDeficits of schizophreniaFrontal cortexPsychotomimetic propertiesNeurobiological effectsDopamine systemPositive symptomsPhencyclidine administrationBehavioral effectsAdministration
1988
Clonidine infusions into the locus coeruleus attenuate behavioral and neurochemical changes associated with naloxone-precipitated withdrawal
Taylor J, Elsworth J, Garcia E, Grant S, Roth R, Redmond D. Clonidine infusions into the locus coeruleus attenuate behavioral and neurochemical changes associated with naloxone-precipitated withdrawal. Psychopharmacology 1988, 96: 121-134. PMID: 3147472, DOI: 10.1007/bf02431544.Peer-Reviewed Original ResearchConceptsNaloxone-precipitated withdrawalDorsal parabrachial nucleusAlpha-2 adrenergic receptorsWet dog shakesLocus coeruleusClonidine infusionMHPG concentrationsOpiate withdrawalAlpha-2 adrenergic agonistsAnti-withdrawal actionWithdrawal-induced increasesBlood-brain barrierInfusion of clonidineNucleus locus coeruleusOccurrence of diarrheaClonidine's abilityLC infusionBrain concentrationsNoradrenergic neuronsST-91MHPG levelsPeripheral injectionWithdrawal signsNeurochemical changesParabrachial nucleus