2001
Impaired Inhibition of Conditioned Responses Produced by Subchronic Administration of Phencyclidine to Rats
Jentsch J, Taylor J. Impaired Inhibition of Conditioned Responses Produced by Subchronic Administration of Phencyclidine to Rats. Neuropsychopharmacology 2001, 24: 66-74. PMID: 11106877, DOI: 10.1016/s0893-133x(00)00174-3.Peer-Reviewed Original ResearchConceptsPCP-treated ratsStimulus-reward associationsNovel instrumental responseInhibitory response controlObsessive-compulsive disorderMore responsesConcurrent discriminationReversal learningFrontostriatal systemIncentive stimuliAffective impairmentsInhibitory controlInstrumental respondingImpaired inhibitionConditioned responseInstrumental responsePCP treatmentResponse controlMental disordersCurrent studyDrug abuseStimuliLearningSubchronic administrationImpulsivity
2000
Object retrieval/detour deficits in monkeys produced by prior subchronic phencyclidine administration: evidence for cognitive impulsivity
Jentsch J, Roth R, Taylor J. Object retrieval/detour deficits in monkeys produced by prior subchronic phencyclidine administration: evidence for cognitive impulsivity. Biological Psychiatry 2000, 48: 415-424. PMID: 10978725, DOI: 10.1016/s0006-3223(00)00926-4.Peer-Reviewed Original ResearchConceptsPhencyclidine administrationObject retrieval detour taskFrontal cortical dysfunctionFrontal cortex ablationSubchronic phencyclidine administrationPerformance of trialsDrugs of abusePhencyclidine exposureSubchronic administrationIntermittent administrationCortical dysfunctionDrug withdrawalChronic consumptionDopaminergic dysfunctionBehavioral deficitsPsychotomimetic drugsCorticostriatal functionInhibitory response controlCognitive impairmentImpaired acquisitionNonhuman primatesAdministrationPhencyclidineDysfunctionInhibitory controlRole for dopamine in the behavioral functions of the prefrontal corticostriatal system: implications for mental disorders and psychotropic drug action
Jentsch J, Roth R, Taylor J. Role for dopamine in the behavioral functions of the prefrontal corticostriatal system: implications for mental disorders and psychotropic drug action. Progress In Brain Research 2000, 126: 433-453. PMID: 11105661, DOI: 10.1016/s0079-6123(00)26028-7.Peer-Reviewed Original ResearchMeSH KeywordsAmphetaminesAmygdalaAnimalsBehaviorBrain MappingCentral Nervous System StimulantsCognitionCorpus StriatumDepressionDopamineDopamine AgonistsEmotionsHaplorhiniHumansLearningLimbic SystemMammalsMemoryMental DisordersNeural PathwaysNeurotransmitter AgentsNucleus AccumbensPhencyclidinePrefrontal CortexPsychotropic DrugsReceptors, NeurotransmitterRewardSchizophreniaSubstance-Related DisordersConceptsForebrain sitesPsychotropic drug actionPrecise anatomical sitesRole of dopamineDopaminergic dysfunctionDopaminergic transmissionDopaminergic functionDopamine neuronsDopaminergic responseReward-related stimuliCorticolimbic circuitsChronic activationDopaminergic activationStriatal regionsAfferent controlAnatomical sitesCorticostriatal systemMental disordersNeuropsychiatric disordersNeuromodulatory systemsPersistent neuroadaptationsDrug actionBehavioral functionsCellular mechanismsDopamine
1999
Altered frontal cortical dopaminergic transmission in monkeys after subchronic phencyclidine exposure: involvement in frontostriatal cognitive deficits
Jentsch J, Taylor J, Elsworth J, Redmond D, Roth R. Altered frontal cortical dopaminergic transmission in monkeys after subchronic phencyclidine exposure: involvement in frontostriatal cognitive deficits. Neuroscience 1999, 90: 823-832. PMID: 10218783, DOI: 10.1016/s0306-4522(98)00481-3.Peer-Reviewed Original ResearchConceptsCognitive deficitsSubchronic phencyclidine administrationDorsolateral prefrontal cortexFrontal cortexCortical dopamine transmissionReduced dopaminergic functionFrontostriatal functionDetour taskCognitive performanceDopamine utilizationPhencyclidine exposurePrefrontal cortexPerformance impairmentPrelimbic cortexBrain regionsCognitive dysfunctionCortical impairmentCortical regionsCognitive impairmentDopaminergic functionPhencyclidine administrationDopamine transmissionSpecific subregionsCortexPsychotomimetic drug phencyclidineDopamine D4 receptor antagonist reversal of subchronic phencyclidine-induced object retrieval/detour deficits in monkeys
Jentsch J, Taylor J, Redmond Jr D, Elsworth J, Youngren K, Roth R. Dopamine D4 receptor antagonist reversal of subchronic phencyclidine-induced object retrieval/detour deficits in monkeys. Psychopharmacology 1999, 142: 78-84. PMID: 10102786, DOI: 10.1007/s002130050865.Peer-Reviewed Original ResearchConceptsFrontostriatal systemCognitive functionPrefrontal cortexObject retrieval taskRegulation of cognitionPrimate prefrontal cortexD4 dopamine receptorsNormal control monkeysDR antagonistsCognitive processesDetour taskCognitive deficitsPerformance impairmentBrain regionsCognitive dysfunctionRetrieval tasksFrontal cortexTaskCortexCortical dopaminergicDeficitsDopaminergic systemAntagonist reversalControl subjectsDopamine receptors
1998
Subchronic Phencyclidine Administration Increases Mesolimbic Dopaminergic System Responsivity and Augments Stress- and Psychostimulant-Induced Hyperlocomotion
Jentsch J, Taylor J, Roth R. Subchronic Phencyclidine Administration Increases Mesolimbic Dopaminergic System Responsivity and Augments Stress- and Psychostimulant-Induced Hyperlocomotion. Neuropsychopharmacology 1998, 19: 105-113. PMID: 9629564, DOI: 10.1016/s0893-133x(98)00004-9.Peer-Reviewed Original ResearchMeSH Keywords3,4-Dihydroxyphenylacetic AcidAnalysis of VarianceAnimalsBrainDextroamphetamineDisease Models, AnimalDizocilpine MaleateDopamineDrug Administration ScheduleHaloperidolLimbic SystemMaleMotor ActivityPhencyclidinePrefrontal CortexRatsRats, Sprague-DawleySchizophreniaStress, PsychologicalTime FactorsConceptsDopamine utilizationHaloperidol-induced increasePCP exposureFrontal cortical dysfunctionAmphetamine-induced hyperlocomotionSubchronic PCP administrationMesolimbic dopamine transmissionPCP-treated ratsCortical dopaminergicCortical dysfunctionDopaminergic deficitDopaminergic transmissionDopaminergic functionDopamine transmissionDopaminergic hypoactivityPCP administrationBehavioral pathologyCognitive deficitsRatsSystem responsivityHyperlocomotionDopaminergicExposureCurrent studyDeficitsPrefrontal cortical involvement in phencyclidine-induced activation of the mesolimbic dopamine system: behavioral and neurochemical evidence
Jentsch J, Tran A, Taylor J, Roth R. Prefrontal cortical involvement in phencyclidine-induced activation of the mesolimbic dopamine system: behavioral and neurochemical evidence. Psychopharmacology 1998, 138: 89-95. PMID: 9694531, DOI: 10.1007/s002130050649.Peer-Reviewed Original ResearchConceptsMesolimbic dopamine systemPrefrontal cortexInduced hyperlocomotionDopamine neuronsDopamine releaseNucleus accumbensDopamine systemInjection of phencyclidineMesocorticolimbic dopaminergic neuronsMesolimbic dopamine neuronsVentral tegmental areaCell body regionIbotenic acid lesionsPrefrontal Cortical InvolvementProfound cognitive impairmentGlutamatergic releaseNeurochemical evidenceAcute administrationCortical involvementDopamine utilizationDopaminergic neuronsMesolimbic pathwayTegmental areaAcid lesionsDopaminergic activation
1997
Enduring Cognitive Deficits and Cortical Dopamine Dysfunction in Monkeys After Long-Term Administration of Phencyclidine
Jentsch J, Redmond D, Elsworth J, Taylor J, Youngren K, Roth R. Enduring Cognitive Deficits and Cortical Dopamine Dysfunction in Monkeys After Long-Term Administration of Phencyclidine. Science 1997, 277: 953-955. PMID: 9252326, DOI: 10.1126/science.277.5328.953.Peer-Reviewed Original ResearchConceptsDopamine utilizationPrefrontal cortexAtypical antipsychotic drug clozapineLong-term administrationDirect drug effectAntipsychotic drug clozapinePsychotomimetic drug phencyclidineAdministration of phencyclidineDorsolateral prefrontal cortexDopamine hypofunctionPrefrontal cortex functionCognitive dysfunctionPhencyclidine treatmentBehavioral deficitsDopamine dysfunctionPsychiatric disordersDrug effectsDrug clozapineDrug phencyclidineBrain regionsCognitive deficitsCortex functionCognitive functionPhencyclidineCortexDysregulation of Mesoprefrontal Dopamine Neurons Induced by Acute and Repeated Phencyclidine Administration in the Nonhuman Primate: Implications for Schizophrenia
Jentsch J, Elsworth J, Taylor J, Redmond D, Roth R. Dysregulation of Mesoprefrontal Dopamine Neurons Induced by Acute and Repeated Phencyclidine Administration in the Nonhuman Primate: Implications for Schizophrenia. Advances In Pharmacology 1997, 42: 810-814. PMID: 9328021, DOI: 10.1016/s1054-3589(08)60870-4.Peer-Reviewed Original ResearchConceptsPCP administrationAcute PCP administrationNegative symptomsDA systemMesoprefrontal dopamine neuronsSubcortical DA systemsBrains of patientsSchizophrenia-like symptomatologyDevelopment of neuropathologyDistinct behavioral effectsDAergic dysfunctionDA metabolismDAergic functionDopamine neuronsCognitive dysfunctionNovel agentsDeficits of schizophreniaFrontal cortexPsychotomimetic propertiesNeurobiological effectsDopamine systemPositive symptomsPhencyclidine administrationBehavioral effectsAdministration