Object retrieval/detour deficits in monkeys produced by prior subchronic phencyclidine administration: evidence for cognitive impulsivity
Jentsch J, Roth R, Taylor J. Object retrieval/detour deficits in monkeys produced by prior subchronic phencyclidine administration: evidence for cognitive impulsivity. Biological Psychiatry 2000, 48: 415-424. PMID: 10978725, DOI: 10.1016/s0006-3223(00)00926-4.Peer-Reviewed Original ResearchConceptsPhencyclidine administrationObject retrieval detour taskFrontal cortical dysfunctionFrontal cortex ablationSubchronic phencyclidine administrationPerformance of trialsDrugs of abusePhencyclidine exposureSubchronic administrationIntermittent administrationCortical dysfunctionDrug withdrawalChronic consumptionDopaminergic dysfunctionBehavioral deficitsPsychotomimetic drugsCorticostriatal functionInhibitory response controlCognitive impairmentImpaired acquisitionNonhuman primatesAdministrationPhencyclidineDysfunctionInhibitory controlPhencyclidine Model of Frontal Cortical Dysfunction in Nonhuman Primates
Jentsch J, Taylor J, Roth R. Phencyclidine Model of Frontal Cortical Dysfunction in Nonhuman Primates. The Neuroscientist 2000, 6: 263-270. DOI: 10.1177/107385840000600409.Peer-Reviewed Original ResearchPrefrontal cortexFrontal cortical dysfunctionPCP-induced behaviorsIdiopathic psychotic disordersPathophysiology of schizophreniaSchizophrenia-like symptomatologyLong-term intakeDopaminergic interactionsCortical dysfunctionNeurochemical dysfunctionNeurochemical effectsReceptor antagonistCognitive dysfunctionPhencyclidine modelPrimary symptomsPsychotic disordersDysfunctionNonhuman primatesNeurobiological substratesHuman subjectsBehavioral changesCortexSchizophreniaDisordersAberrant behavior