1995
R-(+)-HA-966, an antagonist for the glycine/NMDA receptor, prevents locomotor sensitization to repeated cocaine exposures
Morrow B, Taylor J, Roth R. R-(+)-HA-966, an antagonist for the glycine/NMDA receptor, prevents locomotor sensitization to repeated cocaine exposures. Brain Research 1995, 673: 165-169. PMID: 7757472, DOI: 10.1016/0006-8993(94)01456-r.Peer-Reviewed Original ResearchConceptsGlycine/NMDA receptorHA-966Locomotor sensitizationLocomotor activationNMDA receptorsCocaine administrationSubsequent challenge doseLocomotor stimulant propertiesNMDA receptor complexAcute stimulant effectsChallenge doseReverse toleranceRepeated administrationAcute doseCocaine exposureStimulant effectsGlycine receptorsStimulant propertiesCocaineSensitizationAdministrationReceptorsReceptor complexAntagonistDose
1993
Serotonin involvement in cocaine sensitization: Clues from studies with cocaine analogs
Elsworth J, Taylor J, Jatlow P, Roth R. Serotonin involvement in cocaine sensitization: Clues from studies with cocaine analogs. Drug Development Research 1993, 30: 189-200. DOI: 10.1002/ddr.430300311.Peer-Reviewed Original ResearchLocomotor activityAcute dose-response studySubsequent challenge doseΒ-CITCentral dopamine systemsInhibitor of serotoninDopamine uptake sitesCocaine-induced sensitizationInhibitors of dopamineDose-response studyUptake of dopamineRat locomotor activitySerotonin componentConcurrent ingestionChallenge doseSerotonin uptakeNorepinephrine uptakeSerotonergic systemChronic cocaineDopamine systemDopamine uptakeCocaine actionUptake sitesBehavioral effectsComparative potency