2017
Mecamylamine treatment for alcohol dependence: a randomized controlled trial
Petrakis IL, Ralevski E, Gueorguieva R, O'Malley SS, Arias A, Sevarino KA, Jane JS, O'Brien E, Krystal JH. Mecamylamine treatment for alcohol dependence: a randomized controlled trial. Addiction 2017, 113: 6-14. PMID: 28710873, PMCID: PMC5725262, DOI: 10.1111/add.13943.Peer-Reviewed Original ResearchConceptsHeavy drinking daysDrinking daysAlcohol use disorderUse disordersAlcohol consumptionAlcohol dependenceDouble-blind clinical trialNicotinic acetylcholine receptor antagonistWeeks of treatmentAcetylcholine receptor antagonistCurrent alcohol dependenceSignificant differencesTreatment-seeking smokersMecamylamine treatmentPlacebo groupMonth 3Primary outcomeSmoking statusNicotine withdrawalReceptor antagonistNovel pharmacotherapiesClinical trialsManagement therapyMecamylamineTreatment groups
2015
Prazosin for Veterans with Posttraumatic Stress Disorder and Comorbid Alcohol Dependence: A Clinical Trial
Petrakis IL, Desai N, Gueorguieva R, Arias A, O'Brien E, Jane JS, Sevarino K, Southwick S, Ralevski E. Prazosin for Veterans with Posttraumatic Stress Disorder and Comorbid Alcohol Dependence: A Clinical Trial. Alcohol Clinical And Experimental Research 2015, 40: 178-186. PMID: 26683790, DOI: 10.1111/acer.12926.Peer-Reviewed Original ResearchConceptsPosttraumatic stress disorderUse of prazosinSymptoms of PTSDComorbid alcohol dependenceAlcohol dependenceClinical trialsComorbid conditionsSleep disturbancesNoradrenergic dysregulationAlcohol consumptionStress disorderTreatment of PTSDPTSD symptomsHigh clinical importanceMedication groupPharmacologic optionsPromising medicationMedication effectsMAIN OUTCOMEEffective treatmentPrazosinComorbid disordersClinical importancePsychosocial functionClinical issues
2011
Effects of Acamprosate on Cognition in a Treatment Study of Patients With Schizophrenia Spectrum Disorders and Comorbid Alcohol Dependence
Ralevski E, O'Brien E, Jane JS, Dean E, Dwan R, Petrakis I. Effects of Acamprosate on Cognition in a Treatment Study of Patients With Schizophrenia Spectrum Disorders and Comorbid Alcohol Dependence. The Journal Of Nervous And Mental Disease 2011, 199: 499-505. PMID: 21716064, DOI: 10.1097/nmd.0b013e3182214297.Peer-Reviewed Original ResearchConceptsCognitive functioningSchizophrenia spectrum disordersSpectrum disorderAlcohol dependenceComorbid alcohol dependencePsychotic symptomsSymptoms of psychosisCognitionEffects of acamprosateAlcohol useFunctioningTreatment studiesAlcohol reductionMemorySample of patientsAcamprosate treatmentGroup of patientsNegative effectsAlcohol consumptionDisordersAttentionSymptomsAcamprosatePatientsSchizophrenia
1998
Glucose Effects on Cognition in Adults With Down's Syndrome
Manning C, Honn V, Stone W, Jane J, Gold P. Glucose Effects on Cognition in Adults With Down's Syndrome. Neuropsychology 1998, 12: 479-484. PMID: 9674002, DOI: 10.1037/0894-4105.12.3.479.Peer-Reviewed Original ResearchConceptsControl conditionLong-term memoryBattery of testsDown syndromeAuditory processingVariety of individualsCognitive declineMemoryPoor performanceMajority of testsAlzheimer's diseaseAdultsIndividualsCognitionYears of ageDementiaDS individualsCharacteristic plaquesParticipantsSyndromeDiseaseProcessingPeopleAgePerformance