2015
Prazosin for Veterans with Posttraumatic Stress Disorder and Comorbid Alcohol Dependence: A Clinical Trial
Petrakis IL, Desai N, Gueorguieva R, Arias A, O'Brien E, Jane JS, Sevarino K, Southwick S, Ralevski E. Prazosin for Veterans with Posttraumatic Stress Disorder and Comorbid Alcohol Dependence: A Clinical Trial. Alcohol Clinical And Experimental Research 2015, 40: 178-186. PMID: 26683790, DOI: 10.1111/acer.12926.Peer-Reviewed Original ResearchConceptsPosttraumatic stress disorderUse of prazosinSymptoms of PTSDComorbid alcohol dependenceAlcohol dependenceClinical trialsComorbid conditionsSleep disturbancesNoradrenergic dysregulationAlcohol consumptionStress disorderTreatment of PTSDPTSD symptomsHigh clinical importanceMedication groupPharmacologic optionsPromising medicationMedication effectsMAIN OUTCOMEEffective treatmentPrazosinComorbid disordersClinical importancePsychosocial functionClinical issues
2013
Characteristics and drinking patterns of veterans with alcohol dependence with and without post-traumatic stress disorder
Fuehrlein B, Ralevski E, O'Brien E, Jane JS, Arias AJ, Petrakis IL. Characteristics and drinking patterns of veterans with alcohol dependence with and without post-traumatic stress disorder. Addictive Behaviors 2013, 39: 374-378. PMID: 24090619, DOI: 10.1016/j.addbeh.2013.08.026.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAdrenergic alpha-AntagonistsAdultAgedAlcohol DrinkingAlcoholismComorbidityConnecticutDiagnosis, Dual (Psychiatry)FemaleHumansMaleMassachusettsMecamylamineMental DisordersMiddle AgedNicotinic AntagonistsPlacebosPrazosinPsychotropic DrugsSeverity of Illness IndexStress Disorders, Post-TraumaticSubstance-Related DisordersTreatment OutcomeVeteransYoung AdultConceptsPost-traumatic stress disorderCo-occurring illnessesAlcohol dependenceStress disorderCo-occurring alcohol dependenceDetailed drinking historiesDifferent treatment studiesMajor depressive episodeClinical treatment settingsHeavy drinking daysAlcohol use disorderPre-treatment characteristicsBaseline characteristicsDepressive episodePsychiatric symptomsUse disordersDrinking daysDomains of psychopathologyTreatment settingsDrinking historyTreatment studiesPsychopathological domainsPTSD groupPTSD symptomsMore days