2024
Extrapolating Sentinel Surveillance Information to Estimate National COVID Hospital Admission Rates: A Bayesian Modeling Approach
Devine O, Pham H, Gunnels B, Reese H, Steele M, Couture A, Iuliano D, Sachdev D, Alden N, Meek J, Witt L, Ryan P, Reeg L, Lynfield R, Ropp S, Barney G, Tesini B, Shiltz E, Sutton M, Talbot H, Reyes I, Havers F. Extrapolating Sentinel Surveillance Information to Estimate National COVID Hospital Admission Rates: A Bayesian Modeling Approach. Influenza And Other Respiratory Viruses 2024, 18: e70026. PMID: 39440677, PMCID: PMC11497105, DOI: 10.1111/irv.70026.Peer-Reviewed Original ResearchBarriers to the Uptake of Tickborne Disease Prevention Measures: Connecticut, Maryland 2016-2017
Hansen A, Wilkinson M, Niesobecki S, Rutz H, Meek J, Niccolai L, Hinckley A, Hook S. Barriers to the Uptake of Tickborne Disease Prevention Measures: Connecticut, Maryland 2016-2017. Journal Of Public Health Management And Practice 2024, 31: e52-e60. PMID: 39321400, DOI: 10.1097/phh.0000000000002033.Peer-Reviewed Original ResearchPersonal safety concernsPreventive measuresBarriers to consistent usePublic health programsLogistic regression modelsHealth programsTickborne diseasesDisease prevention measuresDemographic variablesPrimary barrierOutdoor activitiesTick checksDescriptive analysisOnline surveyRegression modelsSafety concernsCost concernsNatural pesticidesIncreased uptakePreventionBarriersTick habitatsSurveyConnecticutConcernsCharacteristics of Patients With Initial Clostridioides difficile Infection (CDI) That Are Associated With Increased Risk of Multiple CDI Recurrences
Guh A, Li R, Korhonen L, Winston L, Parker E, Czaja C, Johnston H, Basiliere E, Meek J, Olson D, Fridkin S, Wilson L, Perlmutter R, Holzbauer S, D’Heilly P, Phipps E, Flores K, Dumyati G, Pierce R, Ocampo V, Wilson C, Watkins J, Gerding D, McDonald L. Characteristics of Patients With Initial Clostridioides difficile Infection (CDI) That Are Associated With Increased Risk of Multiple CDI Recurrences. Open Forum Infectious Diseases 2024, 11: ofae127. PMID: 38577028, PMCID: PMC10993058, DOI: 10.1093/ofid/ofae127.Peer-Reviewed Original ResearchRecurrent Clostridioides difficile infectionClostridioides difficile infectionInitial CDINitrofurantoin useMultiple recurrent Clostridioides difficile infectionsPositive testPositive C. difficile testMultiple CDI recurrencesMultivariate logistic regression analysisPrevent further recurrenceAssociated with increased riskIntervention study designProportion of patientsTime of presentationCharacteristics of patientsLogistic regression analysisClinical decision makingCDI recurrenceChronic hemodialysisAdjunctive therapyIncreased riskMultivariate analysisStudy designPatientsClinical setting
2023
1368. In-hospital and post-discharge mortality among adults with COVID-19 associated hospitalization, COVID-NET, March 2020–April 2021.
Patel K, Kirley P, Kawasaki B, Meek J, Openo K, Monroe M, Henderson J, Lynfield R, Sosin D, Rowe A, Bushey S, Shiltz E, Sutton M, Talbot H, Swain A, Whitaker M, Taylor C, Havers F. 1368. In-hospital and post-discharge mortality among adults with COVID-19 associated hospitalization, COVID-NET, March 2020–April 2021. Open Forum Infectious Diseases 2023, 10: ofad500.1205. PMCID: PMC10677354, DOI: 10.1093/ofid/ofad500.1205.Peer-Reviewed Original ResearchCOVID-19-Associated Hospitalization Surveillance NetworkPost-discharge mortalityCOVID-19-associated hospitalizationLaboratory-confirmed COVID-19Hospitalization ratesHospital mortalityChart reviewAdult ageLaboratory-confirmed COVID-19-associated hospitalizationsCOVID-19Positive SARS-CoV-2 testAge groupsPopulation-based surveillance systemSARS-CoV-2 testSurveillance networkDetailed chart reviewFull chart reviewDeath certificate dataProportion of mortalityHospital dischargeCase definitionCertificate dataHospitalizationHospitalMortality473. Trends among hospitalized pregnant patients with laboratory-confirmed SARS-CoV-2 — COVID-NET, 14 U.S. States, January 2021–January 2023
Havers F, Whitaker M, Milucky J, Patton M, Chatwani B, Chai S, Armistead I, Meek J, Openo K, Weigel A, Ryan P, Nunez V, Bye E, Rudin D, Engesser K, Bushey S, Moran N, Sutton M, Talbot H, Olsen K, Taylor C. 473. Trends among hospitalized pregnant patients with laboratory-confirmed SARS-CoV-2 — COVID-NET, 14 U.S. States, January 2021–January 2023. Open Forum Infectious Diseases 2023, 10: ofad500.543. PMCID: PMC10679218, DOI: 10.1093/ofid/ofad500.543.Peer-Reviewed Original ResearchSARS-CoV-2 testPositive SARS-CoV-2 testCOVID-19-Associated Hospitalization Surveillance NetworkHospitalized pregnant patientsPregnant patientsRespiratory symptomsClinical outcomesBooster dosesCOVID-19 respiratory symptomsIntensive care unit admissionPositive SARS-CoV-2SARS-CoV-2 infectionPrimary vaccination seriesSymptomatic pregnant patientsCare unit admissionAdverse clinical outcomesSevere clinical outcomesCOVID-19 vaccinationCOVID-19 infectionSARS-CoV-2Unit admissionVaccination seriesAsymptomatic patientsChart abstractionMechanical ventilation684. Characteristics of Patients with Initial Clostridioides difficile Infection (CDI) That Are Associated With Increased Risk of Multiple CDI Recurrences
Guh A, Li R, Korhonen L, Winston L, Parker E, Czaja C, Johnston H, Basiliere E, Meek J, Olson D, Fridkin S, Wilson L, Perlmutter R, Holzbauer S, D’Heilly P, Phipps E, Flores K, Dumyati G, Pierce R, Ocampo V, Wilson C, Watkins J, Gerding D, McDonald L. 684. Characteristics of Patients with Initial Clostridioides difficile Infection (CDI) That Are Associated With Increased Risk of Multiple CDI Recurrences. Open Forum Infectious Diseases 2023, 10: ofad500.746. PMCID: PMC10677783, DOI: 10.1093/ofid/ofad500.746.Peer-Reviewed Original ResearchEmerging Infections ProgramClostridioides difficile infectionInitial Clostridioides difficile infectionInitial CDICharacteristics of patientsRecurrent CDIPositive testNitrofurantoin useRecent hospitalizationDifficile infectionPrevention's Emerging Infections ProgramRecurrent Clostridioides difficile infectionMultivariable logistic regression modelMultiple recurrent CDIPrevious positive testTime of presentationFull chart reviewGrant/research supportPrior positive testLogistic regression modelsRace/ethnicityChronic hemodialysisAdjunctive therapyChart reviewConclusions PatientsOperational Considerations for Using Deer-Targeted 4-Poster Tick Control Devices in a Tick-borne Disease Endemic Community
Hornbostel V, Meek J, Hansen A, Niesobecki S, Nawrocki C, Hinckley A, Connally N. Operational Considerations for Using Deer-Targeted 4-Poster Tick Control Devices in a Tick-borne Disease Endemic Community. Journal Of Public Health Management And Practice 2023, 30: 111-121. PMID: 37566802, PMCID: PMC10840788, DOI: 10.1097/phh.0000000000001809.Peer-Reviewed Original ResearchConceptsEndemic areasFuture public health interventionsPublic health interventionsDisease-endemic areasPublic health agenciesEndemic communitiesHealth interventionsCommunity settingsCommunity-wide approachEffectiveness studiesMonthly costHealth agenciesTick-borne diseasesLone star tickPersonal protectionAcceptability of 4-poster deer treatment devices for community-wide tick control among residents of high Lyme disease incidence counties in Connecticut and New York, USA
Nawrocki C, Piedmonte N, Niesobecki S, Rowe A, Hansen A, Kaufman A, Foster E, Meek J, Niccolai L, White J, Backenson B, Eisen L, Hook S, Connally N, Hornbostel V, Hinckley A. Acceptability of 4-poster deer treatment devices for community-wide tick control among residents of high Lyme disease incidence counties in Connecticut and New York, USA. Ticks And Tick-borne Diseases 2023, 14: 102231. PMID: 37531890, PMCID: PMC10883357, DOI: 10.1016/j.ttbdis.2023.102231.Peer-Reviewed Original ResearchEstimated Effectiveness of JYNNEOS Vaccine in Preventing Mpox: A Multijurisdictional Case-Control Study — United States, August 19, 2022–March 31, 2023
Dalton A, Diallo A, Chard A, Moulia D, Deputy N, Fothergill A, Kracalik I, Wegner C, Markus T, Pathela P, Still W, Hawkins S, Mangla A, Ravi N, Licherdell E, Britton A, Lynfield R, Sutton M, Hansen A, Betancourt G, Rowlands J, Chai S, Fisher R, Danza P, Farley M, Zipprich J, Prahl G, Wendel K, Niccolai L, Castilho J, Payne D, Cohn A, Feldstein L, Group C, Group C, Saadeh K, Snyder R, Anderson M, Anguiano V, Nadle J, Rothrock G, Jones S, Duval L, Herlihy R, Stringer G, Weber R, Phan Q, Sosa L, Meek J, Lee M, Morrow A, Willut C, Carlson J, Kamis K, Nishiyama M, Simien G, Colasanti J, van der Woude T, Archer R, Finn L, Lam J, Moulton B, Peterson E, Bolan R, Garcia-Lopez G, Como-Sabetti K, Ruff A, Schneider D, Robinson T, Anderson B, Engesser K, McGuire S, Rowe A, Pride C, Mitchell J, Tourkina Y, Cieslak P, Fill M, Wiedeman C, Dumyati G, Felsen C, Lewnard J, Akoko B, Mansilla-Dubon K, Ndi D, Talbot H, Tiwari S, Wyatt D. Estimated Effectiveness of JYNNEOS Vaccine in Preventing Mpox: A Multijurisdictional Case-Control Study — United States, August 19, 2022–March 31, 2023. MMWR Morbidity And Mortality Weekly Report 2023, 72: 553-558. PMID: 37200229, PMCID: PMC10205167, DOI: 10.15585/mmwr.mm7220a3.Peer-Reviewed Original ResearchConceptsAdjusted vaccine effectivenessVaccine effectivenessCase-control studyFull vaccinationEmerging Infections Program sitesEmergency use authorizationDuration of protectionPrevention of smallpoxImmunocompetent participantsImmunocompromised participantsControl patientsImmunization PracticesPartial vaccinationIntradermal injectionSubcutaneous injectionVaccinationMonkeypox casesAdministration routeDrug AdministrationVaccine accessLaboratory capacityTransgender adultsVaccineTransgender personsAdvisory CommitteeBacterial and viral infections among adults hospitalized with COVID‐19, COVID‐NET, 14 states, March 2020–April 2022
Shah M, Patel K, Milucky J, Taylor C, Reingold A, Armistead I, Meek J, Anderson E, Weigel A, Reeg L, Como‐Sabetti K, Ropp S, Muse A, Bushey S, Shiltz E, Sutton M, Talbot H, Chatelain R, Havers F, Team T. Bacterial and viral infections among adults hospitalized with COVID‐19, COVID‐NET, 14 states, March 2020–April 2022. Influenza And Other Respiratory Viruses 2023, 17: e13107. PMID: 36875205, PMCID: PMC9981874, DOI: 10.1111/irv.13107.Peer-Reviewed Original ResearchConceptsDay of admissionSARS-CoV-2 infectionHospitalized adultsViral infectionBacterial coinfectionCOVID-19Laboratory-confirmed SARS-CoV-2 infectionBacterial infectionsPopulation-based surveillance systemRhinovirus/enterovirusRespiratory syncytial virusBacterial pathogensCoV-2 virusClinical featuresClinical outcomesViral coinfectionSyncytial virusHuman metapneumovirusParainfluenza virusRisk factorsSterile sitesEndemic coronavirusesRelative riskRelevant bacterial pathogensGram-negative rods
2022
2314. Hospitalizations and Antibiotic Use in the Year Prior to an Incident C. difficile Infection for Medicare Beneficiaries in Four States, 2016–2018
Hatfield K, Baggs J, Reddy S, Aranmolate R, Meek J, Fridkin S, Szydlowski J, Hatwar T, Dumyati G, Watkins J, Wilson C, McDonald L, Jernigan J, Guh A. 2314. Hospitalizations and Antibiotic Use in the Year Prior to an Incident C. difficile Infection for Medicare Beneficiaries in Four States, 2016–2018. Open Forum Infectious Diseases 2022, 9: ofac492.146. PMCID: PMC9752406, DOI: 10.1093/ofid/ofac492.146.Peer-Reviewed Original ResearchOutpatient antibiotic useEmerging Infections ProgramClostridioides difficile infectionAntibiotic useCDI casesDifficile infectionRisk factorsMedicare beneficiariesPrevention's Emerging Infections ProgramAntibiotic classesPrior yearAntibiotic stewardship effortsC. difficile infectionMultiple risk factorsInpatient hospitalization dataMedicare Provider AnalysisTiming of hospitalizationGrant/research supportDifferent antibiotic classesAntibiotic prescriptionsCase patientsMedian lengthOutpatient antibioticsCDI surveillanceCDI diagnosis1877. COVID-19-Associated Hospitalizations among Long-Term Care Facility Residents Ages ≥65 Years — COVID-NET, 14 U.S. States, March 2020–January 2022
Taylor C, Whitaker M, Anglin O, Pham H, Patel K, Milucky J, Reingold A, Alden N, Meek J, Ward K, Teno K, Kohrman A, Como-Sabetti K, Eisenberg N, Spina N, Bushey S, Billing L, Sutton M, Talbot K, Swain A, Havers F. 1877. COVID-19-Associated Hospitalizations among Long-Term Care Facility Residents Ages ≥65 Years — COVID-NET, 14 U.S. States, March 2020–January 2022. Open Forum Infectious Diseases 2022, 9: ofac492.1504. DOI: 10.1093/ofid/ofac492.1504.Peer-Reviewed Original ResearchCOVID-19-associated hospitalizationCOVID-19-Associated Hospitalization Surveillance NetworkLong-term care facilitiesLTCF residentsUnderlying medical conditionsMedical conditionsHospital deathCode statusCOVID-19 Associated HospitalizationsIntensive care unit admissionPopulation-based surveillance networkSignificant independent risk factorsCare unit admissionInvasive mechanical ventilationIndependent risk factorCongestive heart failureMultiple potential confoundersMonth of admissionAcute care hospitalsSurveillance networkPoisson regression modelsRace/ethnicityUnit admissionVaccination statusCare hospital2209. RSV-associated Hospitalizations in Adults Aged ≥18 Years and the Impact of the COVID-19 Pandemic in the United States, October 2018 – February 2022
Havers F, Whitaker M, Pham H, Anglin O, Milucky J, Patel K, Kirley P, Austin E, Meek J, Anderson E, Monroe M, Brown C, Bye E, Pacheco F, Barney G, Cafferky V, Sutton M, Talbot K, Chatelain R, Gerber S, Langley G, Kim L, Taylor C. 2209. RSV-associated Hospitalizations in Adults Aged ≥18 Years and the Impact of the COVID-19 Pandemic in the United States, October 2018 – February 2022. Open Forum Infectious Diseases 2022, 9: ofac492.1828. PMCID: PMC9752662, DOI: 10.1093/ofid/ofac492.1828.Peer-Reviewed Original ResearchRespiratory syncytial virusLaboratory-confirmed respiratory syncytial virusPre-pandemic seasonsNonpharmaceutical interventionsRSV circulationCDC's Emerging Infections ProgramPopulation-based surveillance systemCOVID-19 pandemicGrant/research supportAdults AgedSyncytial virusClinical trialsInfections ProgramHospitalizationRSV seasonalitySignificant causeOlder adultsAdultsCase countsCOVID-19Safety monitoringSurveillance networkSurveillance systemContinued monitoringUnited StatesDrug use and severe outcomes among adults hospitalized with influenza, 2016–2019
Parisi C, Yousey‐Hindes K, Holstein R, O'Halloran A, Kirley P, Alden N, Anderson E, Kim S, McMahon M, Khanlian S, Spina N, Gaitan M, Shiltz E, Thomas A, Schaffner W, Talbot K, Crossland M, Cook R, Garg S, Meek J, Hadler J. Drug use and severe outcomes among adults hospitalized with influenza, 2016–2019. Influenza And Other Respiratory Viruses 2022, 17: e13052. PMID: 36300969, PMCID: PMC9835414, DOI: 10.1111/irv.13052.Peer-Reviewed Original ResearchConceptsSevere outcomesDrug useICU admissionMechanical ventilationInfluenza Hospitalization Surveillance NetworkInfluenza-associated outcomesSevere influenza outcomesPersistent public health problemChronic liver diseaseChronic lung diseasePublic health problemNon-Hispanic blacksLogistic regression modelsHispanics/LatinosSmoke tobaccoInfluenza vaccinationOpioid useImmunosuppressive conditionsInfluenza seasonSevere morbidityInfluenza infectionInfluenza outcomesLiver diseaseLung diseaseChronic conditionsChanges in the microbiology, epidemiology, and outcomes of candidemia in Connecticut: A comparison between two periods using statewide surveillance
Gleason-Vergados J, Clogher P, Meek J, Banach D. Changes in the microbiology, epidemiology, and outcomes of candidemia in Connecticut: A comparison between two periods using statewide surveillance. Infection Control And Hospital Epidemiology 2022, 44: 994-996. PMID: 36004535, DOI: 10.1017/ice.2022.38.Peer-Reviewed Original ResearchCharacteristics and treatment of hospitalized pregnant women with COVID-19
Sekkarie A, Woodruff R, Whitaker M, Kramer M, Zapata L, Ellington S, Meaney-Delman D, Pham H, Patel K, Taylor C, Chai S, Kawasaki B, Meek J, Openo K, Weigel A, Leegwater L, Como-Sabetti K, Ropp S, Muse A, Bennett N, Billing L, Sutton M, Talbot H, Hill M, Havers F, Team C. Characteristics and treatment of hospitalized pregnant women with COVID-19. American Journal Of Obstetrics & Gynecology MFM 2022, 4: 100715. PMID: 35970493, PMCID: PMC9371979, DOI: 10.1016/j.ajogmf.2022.100715.Peer-Reviewed Original ResearchConceptsSymptomatic COVID-19Pregnant womenSystemic steroidsCOVID-19 vaccinationVaccination statusPregnant patientsNonpregnant womenCOVID-19Laboratory-confirmed SARS-CoV-2 infectionPregnancy statusPropensity score-matched cohortCOVID-19-Associated Hospitalization Surveillance NetworkSARS-CoV-2 infectionMedical chart abstractionTreatment-eligible patientsAdverse pregnancy outcomesSymptomatic pregnant womenCOVID-19 vaccination statusHospitalized pregnant womenNon-Hispanic blacksImplementation of treatmentHospitalized womenChart abstractionClinical characteristicsPregnancy outcomesEarly Release - Economic Burden of Reported Lyme Disease in High-Incidence Areas, United States, 2014–2016 - Volume 28, Number 6—June 2022 - Emerging Infectious Diseases journal - CDC
Hook S, Jeon S, Niesobecki S, Hansen A, Meek J, Bjork J, Dorr F, Rutz H, Feldman K, White J, Backenson P, Shankar M, Meltzer M, Hinckley A. Early Release - Economic Burden of Reported Lyme Disease in High-Incidence Areas, United States, 2014–2016 - Volume 28, Number 6—June 2022 - Emerging Infectious Diseases journal - CDC. Emerging Infectious Diseases 2022, 28: 1170-1179. PMID: 35608612, PMCID: PMC9155891, DOI: 10.3201/eid2806.211335.Peer-Reviewed Original ResearchConceptsTotal societal costsSocietal costsLyme diseasePatient costsInfectious Diseases journal - CDCMean patient costMean societal costLyme disease endemic stateTotal patient costsCost-effectiveness analysisDisseminated diseaseProspective studyEarly diagnosisIncidence areaDiseaseEffective preventionProbable diseaseDemographic factorsPrevention methodsComprehensive economic evaluationEconomic evaluationPatientsVaccineIllnessDiagnosisHospitalizations of Children Aged 5–11 Years with Laboratory-Confirmed COVID-19 — COVID-NET, 14 States, March 2020–February 2022
Shi D, Whitaker M, Marks K, Anglin O, Milucky J, Patel K, Pham H, Chai S, Kawasaki B, Meek J, Anderson E, Weigel A, Henderson J, Lynfield R, Ropp S, Muse A, Bushey S, Billing L, Sutton M, Talbot H, Price A, Taylor C, Havers F, Team C. Hospitalizations of Children Aged 5–11 Years with Laboratory-Confirmed COVID-19 — COVID-NET, 14 States, March 2020–February 2022. MMWR Morbidity And Mortality Weekly Report 2022, 71: 574-581. PMID: 35446827, PMCID: PMC9042359, DOI: 10.15585/mmwr.mm7116e1.Peer-Reviewed Original ResearchConceptsCOVID-19-associated hospitalizationCOVID-19-Associated Hospitalization Surveillance NetworkIntensive care unitAge groupsUnvaccinated childrenPfizer-BioNTech COVID-19 vaccineCumulative hospitalization rateNon-Hispanic black childrenSevere COVID-19Immunization Practices recommendationsUnderlying medical conditionsCDC's Advisory CommitteeImportance of vaccinationEmergency use authorizationUnderlying health conditionsCOVID-19 vaccineCOVID-19SARS-CoV-2Advisory CommitteeCare unitHospitalization ratesVaccination coverageSevere outcomesChildren Aged 5Medical conditionsDesigning an Intervention Trial of Human-Tick Encounters and Tick-Borne Diseases in Residential Settings Using 4-Poster Devices to Control Ixodes scapularis (Acari: Ixodidae): Challenges for Site Selection and Device Placement
Connally NP, Rowe A, Kaufman A, Meek JI, Niesobecki SA, Hansen AP, White J, Nawrocki C, Foster E, Hinckley AF, Eisen L. Designing an Intervention Trial of Human-Tick Encounters and Tick-Borne Diseases in Residential Settings Using 4-Poster Devices to Control Ixodes scapularis (Acari: Ixodidae): Challenges for Site Selection and Device Placement. Journal Of Medical Entomology 2022, 59: 911-921. PMID: 35294011, PMCID: PMC10903785, DOI: 10.1093/jme/tjac027.Peer-Reviewed Original ResearchRates of Severe Influenza-Associated Outcomes Among Older Adults Living With Diabetes—Influenza Hospitalization Surveillance Network (FluSurv-NET), 2012–2017
Owusu D, Rolfes M, Arriola C, Kirley P, Alden N, Meek J, Anderson E, Monroe M, Kim S, Lynfield R, Angeles K, Spina N, Felsen C, Billing L, Thomas A, Talbot H, Schaffner W, Chatelain R, Reed C, Garg S. Rates of Severe Influenza-Associated Outcomes Among Older Adults Living With Diabetes—Influenza Hospitalization Surveillance Network (FluSurv-NET), 2012–2017. Open Forum Infectious Diseases 2022, 9: ofac131. PMID: 35450083, PMCID: PMC9017364, DOI: 10.1093/ofid/ofac131.Peer-Reviewed Original ResearchInfluenza-associated outcomesInfluenza-associated hospitalizationsDiabetes mellitusOlder adultsHospital deathMechanical ventilationRate ratioLaboratory-confirmed influenza-associated hospitalizationsInfluenza Hospitalization Surveillance NetworkIntensive care unit admissionImpact of DMPopulation-based surveillance systemStatistics population dataCare unit admissionInfluenza virus infectionConfidence intervalsHigh rateUnit admissionHospitalized adultsICU admissionInfluenza illnessPooled rateAnnual vaccinationEarly treatmentVirus infection