2021
Risk Factors for Severe COVID-19 in Children
Woodruff R, Campbell A, Taylor C, Chai S, Kawasaki B, Meek J, Anderson E, Weigel A, Monroe M, Reeg L, Bye E, Sosin D, Muse A, Bennett N, Billing L, Sutton M, Talbot H, McCaffrey K, Pham H, Patel K, Whitaker M, McMorrow M, Havers F. Risk Factors for Severe COVID-19 in Children. Pediatrics 2021, 149: e2021053418. PMID: 34935038, PMCID: PMC9213563, DOI: 10.1542/peds.2021-053418.Peer-Reviewed Original ResearchConceptsSevere COVID-19Adjusted risk ratioPopulation-based ratesHospitalized childrenRisk factorsCOVID-19Laboratory-confirmed severe acute respiratory syndrome coronavirus 2 infectionAcute respiratory syndrome coronavirus 2 infectionSevere acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infectionSyndrome coronavirus 2 infectionSevere coronavirus disease 2019COVID-19-Associated Hospitalization Surveillance NetworkNon-Hispanic black childrenCoronavirus 2 infectionChronic lung diseaseConfidence intervalsCoronavirus disease 2019COVID-19 vaccineTube dependenceAirway abnormalitiesDiabetes mellitusIllness severityLung diseaseRisk ratioMedical records
2016
Increased Antiviral Treatment Among Hospitalized Children and Adults With Laboratory-Confirmed Influenza, 2010–2015
Appiah GD, Chaves SS, Kirley PD, Miller L, Meek J, Anderson E, Oni O, Ryan P, Eckel S, Lynfield R, Bargsten M, Zansky SM, Bennett N, Lung K, McDonald-Hamm C, Thomas A, Brady D, Lindegren ML, Schaffner W, Hill M, Garg S, Fry AM, Campbell AP. Increased Antiviral Treatment Among Hospitalized Children and Adults With Laboratory-Confirmed Influenza, 2010–2015. Clinical Infectious Diseases 2016, 64: 364-367. PMID: 28013261, PMCID: PMC5480237, DOI: 10.1093/cid/ciw745.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAdultAgedAntiviral AgentsChildChild, PreschoolCohort StudiesFemaleHumansInfantInfant, NewbornInfluenza A Virus, H1N1 SubtypeInfluenza, HumanLength of StayLongitudinal StudiesMaleMiddle AgedOseltamivirPandemicsProspective StudiesRetrospective StudiesSeasonsUnited StatesYoung AdultEffectiveness of Residential Acaricides to Prevent Lyme and Other Tick-borne Diseases in Humans
Hinckley A, Meek J, Ray J, Niesobecki S, Connally N, Feldman K, Jones E, Backenson P, White J, Lukacik G, Kay A, Miranda W, Mead P. Effectiveness of Residential Acaricides to Prevent Lyme and Other Tick-borne Diseases in Humans. The Journal Of Infectious Diseases 2016, 214: 182-188. PMID: 26740276, PMCID: PMC10874626, DOI: 10.1093/infdis/jiv775.Peer-Reviewed Original ResearchConceptsTick-borne diseasesHuman-tick encountersMajor public health concernPlacebo-controlled trialMedical record reviewHuman tick-borne diseasesReports of illnessPublic health concernPublic health authoritiesTick-borne diseaseRecord reviewTick biteTick exposureTreatment groupsHealth authoritiesDiseaseHealth concernQuesting ticksHuman outcomesTicksUse of acaricidesIllnessIncidenceTrialsWeeks
2015
Burden of Clostridium difficile Infection in the United States
Lessa F, Mu Y, Bamberg W, Beldavs Z, Dumyati G, Dunn J, Farley M, Holzbauer S, Meek J, Phipps E, Wilson L, Winston L, Cohen J, Limbago B, Fridkin S, Gerding D, McDonald L. Burden of Clostridium difficile Infection in the United States. New England Journal Of Medicine 2015, 372: 825-834. PMID: 25714160, PMCID: PMC10966662, DOI: 10.1056/nejmoa1408913.Peer-Reviewed Original ResearchConceptsClostridium difficile infectionDifficile infectionFirst recurrenceHealth care-associated infectionsCommunity-associated infectionsC. difficile infectionCare-associated infectionsPersons 65 yearsLaboratory-based surveillanceType 1 strainsNumber of deathsNational incidenceMolecular typingC. difficileInfectionIncidenceDeathUnited StatesRecurrenceGeographic areasSample of casesEstimated numberRegression modelsActive populationHealth
2014
The Burden of Influenza Hospitalizations in Infants From 2003 to 2012, United States
Chaves S, Perez A, Farley M, Miller L, Schaffner W, Lindegren M, Sharangpani R, Meek J, Yousey-Hindes K, Thomas A, Boulton R, Baumbach J, Hancock E, Bandyopadhyay A, Lynfield R, Morin C, Zansky S, Reingold A, Bennett N, Ryan P, Fowler B, Fry A, Finelli L. The Burden of Influenza Hospitalizations in Infants From 2003 to 2012, United States. The Pediatric Infectious Disease Journal 2014, 33: 912-919. PMID: 24577042, DOI: 10.1097/inf.0000000000000321.Peer-Reviewed Original ResearchConceptsImpact of influenzaHigh-risk conditionsHospitalization ratesRisk factorsOlder infantsIntensive care unit admissionInfluenza-associated hospitalization ratesCare unit admissionRisk conditionsInfluenza hospitalizationsUnit admissionICU admissionInfluenza vaccinationRespiratory failureClinical characteristicsInfant hospitalizationHealthy infantsMost hospitalizationsPregnant womenLung diseaseCardiovascular diseaseUS infantsHospitalizationYoung infantsInfantsChild, Household, and Caregiver Characteristics Associated with Hospitalization for Influenza Among Children 6–59 Months of Age
Dharan N, Sokolow L, Cheng P, Gargiullo P, Gershman K, Lynfield R, Morin C, Thomas A, Meek J, Farley M, Arnold K, Reingold A, Craig A, Schaffner W, Bennett N, Zansky S, Baumbach J, Lathrop S, Kamimoto L, Shay D. Child, Household, and Caregiver Characteristics Associated with Hospitalization for Influenza Among Children 6–59 Months of Age. The Pediatric Infectious Disease Journal 2014, 33: e141-e150. PMID: 24642518, PMCID: PMC4025593, DOI: 10.1097/inf.0000000000000283.Peer-Reviewed Original ResearchConceptsMonths of ageChildren 6Influenza hospitalizationsInfluenza illnessInfluenza vaccinationMaternal ageRisk factorsSevere outcomesChronic illnessEmerging Infections Program sitesLaboratory-confirmed influenza infectionIndependent risk factorInfluenza-associated hospitalizationsYoung maternal ageCase-control studyConditional logistic regressionYoung childrenHematologic/Influenza immunizationHousehold smokingEligible casesInfluenza infectionNeurologic conditionsEligible controlsMedical recordsClostridium difficile Infection Among Children Across Diverse US Geographic Locations
Wendt J, Cohen J, Mu Y, Dumyati G, Dunn J, Holzbauer S, Winston L, Johnston H, Meek J, Farley M, Wilson L, Phipps E, Beldavs Z, Gerding D, McDonald L, Gould C, Lessa F. Clostridium difficile Infection Among Children Across Diverse US Geographic Locations. Pediatrics 2014, 133: 651-658. PMID: 24590748, PMCID: PMC10932476, DOI: 10.1542/peds.2013-3049.Peer-Reviewed Original ResearchConceptsClostridium difficile infectionAge groupsCDI incidenceDifficile infectionCommunity-associated casesProportion of casesYears of ageHealth care facilitiesYoung childrenSimilar disease severityUnnecessary antimicrobial useUS geographic areasHospital admissionClinical presentationCDI surveillanceOutpatient settingCDI casesC difficileEtiologic roleClinical dataSevere diseaseStool collectionCare facilitiesDisease severityCA cases
2013
Complications and Associated Bacterial Coinfections Among Children Hospitalized With Seasonal or Pandemic Influenza, United States, 2003–2010
Dawood F, Chaves S, Pérez A, Reingold A, Meek J, Farley M, Ryan P, Lynfield R, Morin C, Baumbach J, Bennett N, Zansky S, Thomas A, Lindegren M, Schaffner W, Finelli L, Network F. Complications and Associated Bacterial Coinfections Among Children Hospitalized With Seasonal or Pandemic Influenza, United States, 2003–2010. The Journal Of Infectious Diseases 2013, 209: 686-694. PMID: 23986545, DOI: 10.1093/infdis/jit473.Peer-Reviewed Original ResearchConceptsIntensive carePandemic influenzaLaboratory-confirmed influenza hospitalizationsBacteremia/sepsisInfluenza-associated complicationsIntensive care requirementAcute renal failurePopulation-based surveillanceSeverity of complicationsMedian hospitalization durationNinth Revision codesInfluenza hospitalizationsAsthma exacerbationsHospitalization durationInfluenza vaccinationRespiratory failureCommon complicationRenal failureBacterial coinfectionProlonged hospitalizationMedian lengthPrimary preventionRevision codesSeasonal influenzaHospitalized childrenEffectiveness of Nonadjuvanted Monovalent Influenza A(H1N1)pdm09 Vaccines for Preventing Reverse Transcription Polymerase Chain Reaction–Confirmed Pandemic Influenza Hospitalizations: Case-Control Study of Children and Adults at 10 US Influenza Surveillance Network Sites
Thompson M, Sokolow L, Almendares O, Openo K, Farley M, Meek J, Ray J, Kirley P, Reingold A, Aragon D, Hancock E, Baumbach J, Schaffner W, Thomas A, Lynfield R, Ryan P, Monroe M, Cheng P, Fry A, Shay D. Effectiveness of Nonadjuvanted Monovalent Influenza A(H1N1)pdm09 Vaccines for Preventing Reverse Transcription Polymerase Chain Reaction–Confirmed Pandemic Influenza Hospitalizations: Case-Control Study of Children and Adults at 10 US Influenza Surveillance Network Sites. Clinical Infectious Diseases 2013, 57: 1587-1592. PMID: 23956169, PMCID: PMC7314184, DOI: 10.1093/cid/cit551.Peer-Reviewed Original ResearchConceptsLaboratory-confirmed pandemic influenzaCommunity-matched controlsCase-control studyReverse transcription-polymerase chain reactionTranscription-polymerase chain reactionInfluenza hospitalizationsMonovalent influenzaPandemic influenzaSingle dosePolymerase chain reactionVirus infectionInfluenzaChain reactionHospitalizationVaccinePatientsInfectionDose
2012
Guillain-Barré Syndrome During the 2009–2010 H1N1 Influenza Vaccination Campaign: Population-based Surveillance Among 45 Million Americans
Wise M, Viray M, Sejvar J, Lewis P, Baughman A, Connor W, Danila R, Giambrone G, Hale C, Hogan B, Meek J, Murphree R, Oh J, Reingold A, Tellman N, Conner S, Singleton J, Lu P, DeStefano F, Fridkin S, Vellozzi C, Morgan O. Guillain-Barré Syndrome During the 2009–2010 H1N1 Influenza Vaccination Campaign: Population-based Surveillance Among 45 Million Americans. American Journal Of Epidemiology 2012, 175: 1110-1119. PMID: 22582209, PMCID: PMC3888111, DOI: 10.1093/aje/kws196.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAdultAgedChildChild, PreschoolFemaleGuillain-Barre SyndromeHealth PromotionHumansIncidenceInfantInfluenza A Virus, H1N1 SubtypeInfluenza VaccinesInfluenza, HumanMaleMiddle AgedPopulation SurveillanceProduct Surveillance, PostmarketingRisk AssessmentTime FactorsUnited StatesYoung AdultConceptsGuillain-Barré syndromePopulation-based surveillanceGBS casesPH1N1 vaccineInfluenza A (H1N1) 2009 monovalent vaccineRate of GBSEmerging Infections Program sitesSex-adjusted rate ratiosH1N1 influenza vaccineMedical record reviewVaccine coverage dataInfluenza vaccination campaignGBS incidencePH1N1 vaccinationInfluenza vaccineMonovalent vaccineRecord reviewIncident casesVaccine dosesExcess riskPatient interviewsGBS riskVaccine campaignVaccine historyVaccination campaignReduced Influenza Antiviral Treatment Among Children and Adults Hospitalized With Laboratory-Confirmed Influenza Infection in the Year After the 2009 Pandemic
Garg S, Chaves SS, Pérez A, D'Mello T, Gershman K, Meek J, Yousey-Hindes K, Arnold KE, Farley MM, Tengelsen L, Ryan P, Sharangpani R, Lynfield R, Morin C, Baumbach J, Hancock EB, Zansky S, Bennett NM, Fowler B, Bradley K, Thomas A, Cooper T, Schaffner W, Boulton R, Finelli L, Fry AM. Reduced Influenza Antiviral Treatment Among Children and Adults Hospitalized With Laboratory-Confirmed Influenza Infection in the Year After the 2009 Pandemic. Clinical Infectious Diseases 2012, 55: e18-e21. PMID: 22543024, DOI: 10.1093/cid/cis442.Peer-Reviewed Original Research
2011
Leveraging State Immunization Information Systems to Measure the Effectiveness of Rotavirus Vaccine
Cortese M, LeBlanc J, White K, Jerris R, Stinchfield P, Preston K, Meek J, Odofin L, Khizer S, Miller C, Buttery V, Mijatovic-Rustempasic S, Lewis J, Parashar U, Immergluck L. Leveraging State Immunization Information Systems to Measure the Effectiveness of Rotavirus Vaccine. Pediatrics 2011, 128: e1474-e1481. PMID: 22084328, PMCID: PMC8202521, DOI: 10.1542/peds.2011-1006.Peer-Reviewed Original ResearchConceptsImmunization Information SystemVaccine effectivenessControl groupState Immunization Information SystemRotavirus vaccine effectivenessRotavirus-negative controlsVaccine-eligible childrenEffectiveness of vaccinesVE point estimatesCase-control methodologyYears of lifeRotavirus diseaseRotavirus vaccineNegative childrenEmergency departmentRotavirus seasonRotavirus antigenImmunization recordsEligibility criteriaUS childrenImmunization dataMonthsDosesZip codesChildrenClostridium difficile Infection in Outpatients, Maryland and Connecticut, USA, 2002–2007 - Volume 17, Number 10—October 2011 - Emerging Infectious Diseases journal - CDC
Hirshon JM, Thompson AD, Limbago B, McDonald LC, Bonkosky M, Heimer R, Meek J, Mai V, Braden C. Clostridium difficile Infection in Outpatients, Maryland and Connecticut, USA, 2002–2007 - Volume 17, Number 10—October 2011 - Emerging Infectious Diseases journal - CDC. Emerging Infectious Diseases 2011, 17: 1946-1949. PMID: 22000379, PMCID: PMC3310666, DOI: 10.3201/eid1710.110069.Peer-Reviewed Original Research
2010
Influenza-Associated Pneumonia in Children Hospitalized With Laboratory-Confirmed Influenza, 2003–2008
Dawood FS, Fiore A, Kamimoto L, Nowell M, Reingold A, Gershman K, Meek J, Hadler J, Arnold KE, Ryan P, Lynfield R, Morin C, Baumbach J, Zansky S, Bennett NM, Thomas A, Schaffner W, Kirschke D, Finelli L. Influenza-Associated Pneumonia in Children Hospitalized With Laboratory-Confirmed Influenza, 2003–2008. The Pediatric Infectious Disease Journal 2010, 29: 585-590. PMID: 20589966, PMCID: PMC5856105, DOI: 10.1097/inf.0b013e3181d411c5.Peer-Reviewed Original ResearchConceptsInfluenza-associated pneumoniaChest radiographsHospitalized childrenIntensive care unit admissionCare unit admissionLaboratory-confirmed influenzaSevere clinical courseInfluenza complicationsUnit admissionRespiratory failureCommon complicationClinical courseInfluenza seasonTreatment strategiesPneumoniaMultivariate analysisNew pneumoniaGreater riskInfluenzaRadiographsAge 6Age 2HospitalizationAsthmaComplicationsBurden of Seasonal Influenza Hospitalization in Children, United States, 2003 to 2008
Dawood FS, Fiore A, Kamimoto L, Bramley A, Reingold A, Gershman K, Meek J, Hadler J, Arnold KE, Ryan P, Lynfield R, Morin C, Mueller M, Baumbach J, Zansky S, Bennett NM, Thomas A, Schaffner W, Kirschke D, Finelli L, Network E. Burden of Seasonal Influenza Hospitalization in Children, United States, 2003 to 2008. The Journal Of Pediatrics 2010, 157: 808-814. PMID: 20580018, DOI: 10.1016/j.jpeds.2010.05.012.Peer-Reviewed Original ResearchConceptsSevere outcomesInfluenza hospitalizationsHospitalization ratesHospitalized childrenEmerging Infections Program NetworkIntensive care unit admissionInfections Program NetworkSeasonal influenza hospitalizationsCare unit admissionLaboratory-confirmed influenzaPopulation-based surveillanceUnderlying medical conditionsHigher hospitalization ratesRate of hospitalizationProportion of childrenRapid diagnostic testsUnit admissionRespiratory failureBacterial coinfectionClinical courseHospital recordsSeasonal influenzaMedical historyDisease burdenIncidence rate
2009
Peridomestic Lyme Disease Prevention Results of a Population-Based Case–Control Study
Connally NP, Durante AJ, Yousey-Hindes KM, Meek JI, Nelson RS, Heimer R. Peridomestic Lyme Disease Prevention Results of a Population-Based Case–Control Study. American Journal Of Preventive Medicine 2009, 37: 201-206. PMID: 19595558, DOI: 10.1016/j.amepre.2009.04.026.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAdultAgedAged, 80 and overAnimalsCase-Control StudiesChildChild, PreschoolConnecticutEnvironment DesignEnvironmental ExposureFemaleHumansHygieneInfantLogistic ModelsLyme DiseaseMaleMatched-Pair AnalysisMiddle AgedPopulation SurveillanceProspective StudiesResidence CharacteristicsRisk FactorsSurveys and QuestionnairesTicksYoung AdultConceptsCase-control studyLyme diseaseDisease prevention initiativesConditional logistic regressionDisease prevention measuresErythema migransPotential confoundersRecreational exposureLogistic regressionProspective ageDiseaseCase onsetPrevention resultsPrevention measuresPersonal protectionRiskHoursConfoundersMigransTicksInfectionStudyConnecticut communitiesMonths
2008
Performance of an Algorithm for Assessing Smallpox Risk among Patients with Rashes That May Be Confused with Smallpox
Hutchins S, Sulemana I, Heilpern K, Schaffner W, Wax G, Lerner E, Watson B, Baltimore R, Waltenburg R, Aronsky D, Coffin S, Ng G, Craig A, Behrman A, Meek J, Sherman E, Chavez S, Harpaz R, Schmid S. Performance of an Algorithm for Assessing Smallpox Risk among Patients with Rashes That May Be Confused with Smallpox. Clinical Infectious Diseases 2008, 46: s195-s203. PMID: 18284359, DOI: 10.1086/524383.Peer-Reviewed Original Research
2001
Retrospective validation of a surveillance system for unexplained illness and death: New Haven County, Connecticut.
Kluger M, Sofair A, Heye C, Meek J, Sodhi R, Hadler J. Retrospective validation of a surveillance system for unexplained illness and death: New Haven County, Connecticut. American Journal Of Public Health 2001, 91: 1214-9. PMID: 11499106, PMCID: PMC1446748, DOI: 10.2105/ajph.91.8.1214.Peer-Reviewed Original ResearchConceptsActive prospective surveillanceInfectious causesUnexplained illnessProspective surveillanceRetrospective surveillanceRetrospective validationProspective surveillance systemHospital discharge dataSurveillance systemSuch patientsAnnual incidenceStudy criteriaMedical recordsNew Haven CountyComputerized searchIllnessLess labor-intensive alternativeDeathLabor-intensive alternativePatientsReference populationSurveillanceCauseDischarge dataStudy counties