2022
Drug use and severe outcomes among adults hospitalized with influenza, 2016–2019
Parisi C, Yousey‐Hindes K, Holstein R, O'Halloran A, Kirley P, Alden N, Anderson E, Kim S, McMahon M, Khanlian S, Spina N, Gaitan M, Shiltz E, Thomas A, Schaffner W, Talbot K, Crossland M, Cook R, Garg S, Meek J, Hadler J. Drug use and severe outcomes among adults hospitalized with influenza, 2016–2019. Influenza And Other Respiratory Viruses 2022, 17: e13052. PMID: 36300969, PMCID: PMC9835414, DOI: 10.1111/irv.13052.Peer-Reviewed Original ResearchConceptsSevere outcomesDrug useICU admissionMechanical ventilationInfluenza Hospitalization Surveillance NetworkInfluenza-associated outcomesSevere influenza outcomesPersistent public health problemChronic liver diseaseChronic lung diseasePublic health problemNon-Hispanic blacksLogistic regression modelsHispanics/LatinosSmoke tobaccoInfluenza vaccinationOpioid useImmunosuppressive conditionsInfluenza seasonSevere morbidityInfluenza infectionInfluenza outcomesLiver diseaseLung diseaseChronic conditions
2021
Hospital-acquired influenza in the United States, FluSurv-NET, 2011–2012 through 2018–2019
Cummings C, O’Halloran A, Azenkot T, Reingold A, Alden N, Meek J, Anderson E, Ryan P, Kim S, McMahon M, McMullen C, Spina N, Bennett N, Billing L, Thomas A, Schaffner W, Talbot H, George A, Reed C, Garg S. Hospital-acquired influenza in the United States, FluSurv-NET, 2011–2012 through 2018–2019. Infection Control And Hospital Epidemiology 2021, 43: 1447-1453. PMID: 34607624, DOI: 10.1017/ice.2021.392.Peer-Reviewed Original ResearchConceptsHospital-acquired influenzaInfluenza-associated hospitalizationsHA influenzaHospital infection control measuresInfluenza Hospitalization Surveillance NetworkFacility-based testingPositive test dateRespiratory symptom onsetAnnual influenza vaccinationHA casesInfection control measuresSymptom onset dateCross-sectional studyYears of agePopulation-based ratesInfluenza vaccinationClinical characteristicsICU careSymptom onsetInfluenza vaccineMechanical ventilationSevere outcomesPatient outcomesInfluenza casesHospitalization
2016
Case-Control Study of Vaccine Effectiveness in Preventing Laboratory-Confirmed Influenza Hospitalizations in Older Adults, United States, 2010–2011
Havers F, Sokolow L, Shay D, Farley M, Monroe M, Meek J, Kirley P, Bennett N, Morin C, Aragon D, Thomas A, Schaffner W, Zansky S, Baumbach J, Ferdinands J, Fry A. Case-Control Study of Vaccine Effectiveness in Preventing Laboratory-Confirmed Influenza Hospitalizations in Older Adults, United States, 2010–2011. Clinical Infectious Diseases 2016, 63: 1304-1311. PMID: 27486114, DOI: 10.1093/cid/ciw512.Peer-Reviewed Original ResearchConceptsLaboratory-confirmed influenza hospitalizationsCase-control studyInfluenza hospitalizationsCase patientsAge groupsRecent hospitalizationRespiratory conditionsLower functional status scoresOlder adultsConditional logistic regression modelsAdjusted VE estimatesInfluenza-associated complicationsVaccine effectiveness dataChronic medical conditionsFunctional status scoresMonths of hospitalizationChronic health conditionsLogistic regression modelsPreventing LaboratoryInfluenza vaccinationVaccination statusVaccine effectivenessInfluenza seasonVE estimatesInfluenza infectionBenefit of Early Initiation of Influenza Antiviral Treatment to Pregnant Women Hospitalized With Laboratory-Confirmed Influenza
Oboho I, Reed C, Gargiullo P, Leon M, Aragon D, Meek J, Anderson E, Ryan P, Lynfield R, Morin C, Bargsten M, Zansky S, Fowler B, Thomas A, Lindegren M, Schaffner W, Risk I, Finelli L, Chaves S. Benefit of Early Initiation of Influenza Antiviral Treatment to Pregnant Women Hospitalized With Laboratory-Confirmed Influenza. The Journal Of Infectious Diseases 2016, 214: 507-515. PMID: 26908745, DOI: 10.1093/infdis/jiw033.Peer-Reviewed Original ResearchConceptsInfluenza antiviral treatmentSevere influenzaAntiviral treatmentLength of stayPregnant womenEarly initiationInfluenza vaccinationIntensive care unit admissionAnnual influenza vaccinationCare unit admissionLaboratory-confirmed influenzaUnit admissionPregnancy trimesterPreterm deliveryRespiratory failurePulmonary embolismInfluenza seasonMedian ageSeverity strataMechanical ventilationParametric survival analysisIllness onsetInfant morbidityMedian lengthFetal loss
2015
Does Influenza Vaccination Modify Influenza Severity? Data on Older Adults Hospitalized With Influenza During the 2012−2013 Season in the United States
Arriola C, Anderson E, Baumbach J, Bennett N, Bohm S, Hill M, Lindegren M, Lung K, Meek J, Mermel E, Miller L, Monroe M, Morin C, Oni O, Reingold A, Schaffner W, Thomas A, Zansky S, Finelli L, Chaves S. Does Influenza Vaccination Modify Influenza Severity? Data on Older Adults Hospitalized With Influenza During the 2012−2013 Season in the United States. The Journal Of Infectious Diseases 2015, 212: 1200-1208. PMID: 25821227, PMCID: PMC4683374, DOI: 10.1093/infdis/jiv200.Peer-Reviewed Original ResearchConceptsInfluenza vaccinationInfluenza severityDisease severityIntensive care unit admissionMultivariable logistic regression modelSevere influenza outcomesCare unit admissionLaboratory-confirmed influenzaMultivariable logistic regressionDiagnosis of pneumoniaLogistic regression modelsUnit admissionICU lengthVaccine effectivenessInfluenza seasonParametric survival modelsInfluenza outcomesVaccinated personsVaccinationPropensity scoreLogistic regressionOlder adultsPredominant strainSeverityInfluenza
2014
The Burden of Influenza Hospitalizations in Infants From 2003 to 2012, United States
Chaves S, Perez A, Farley M, Miller L, Schaffner W, Lindegren M, Sharangpani R, Meek J, Yousey-Hindes K, Thomas A, Boulton R, Baumbach J, Hancock E, Bandyopadhyay A, Lynfield R, Morin C, Zansky S, Reingold A, Bennett N, Ryan P, Fowler B, Fry A, Finelli L. The Burden of Influenza Hospitalizations in Infants From 2003 to 2012, United States. The Pediatric Infectious Disease Journal 2014, 33: 912-919. PMID: 24577042, DOI: 10.1097/inf.0000000000000321.Peer-Reviewed Original ResearchConceptsImpact of influenzaHigh-risk conditionsHospitalization ratesRisk factorsOlder infantsIntensive care unit admissionInfluenza-associated hospitalization ratesCare unit admissionRisk conditionsInfluenza hospitalizationsUnit admissionICU admissionInfluenza vaccinationRespiratory failureClinical characteristicsInfant hospitalizationHealthy infantsMost hospitalizationsPregnant womenLung diseaseCardiovascular diseaseUS infantsHospitalizationYoung infantsInfantsChild, Household, and Caregiver Characteristics Associated with Hospitalization for Influenza Among Children 6–59 Months of Age
Dharan N, Sokolow L, Cheng P, Gargiullo P, Gershman K, Lynfield R, Morin C, Thomas A, Meek J, Farley M, Arnold K, Reingold A, Craig A, Schaffner W, Bennett N, Zansky S, Baumbach J, Lathrop S, Kamimoto L, Shay D. Child, Household, and Caregiver Characteristics Associated with Hospitalization for Influenza Among Children 6–59 Months of Age. The Pediatric Infectious Disease Journal 2014, 33: e141-e150. PMID: 24642518, PMCID: PMC4025593, DOI: 10.1097/inf.0000000000000283.Peer-Reviewed Original ResearchConceptsMonths of ageChildren 6Influenza hospitalizationsInfluenza illnessInfluenza vaccinationMaternal ageRisk factorsSevere outcomesChronic illnessEmerging Infections Program sitesLaboratory-confirmed influenza infectionIndependent risk factorInfluenza-associated hospitalizationsYoung maternal ageCase-control studyConditional logistic regressionYoung childrenHematologic/Influenza immunizationHousehold smokingEligible casesInfluenza infectionNeurologic conditionsEligible controlsMedical records
2013
Complications and Associated Bacterial Coinfections Among Children Hospitalized With Seasonal or Pandemic Influenza, United States, 2003–2010
Dawood F, Chaves S, Pérez A, Reingold A, Meek J, Farley M, Ryan P, Lynfield R, Morin C, Baumbach J, Bennett N, Zansky S, Thomas A, Lindegren M, Schaffner W, Finelli L, Network F. Complications and Associated Bacterial Coinfections Among Children Hospitalized With Seasonal or Pandemic Influenza, United States, 2003–2010. The Journal Of Infectious Diseases 2013, 209: 686-694. PMID: 23986545, DOI: 10.1093/infdis/jit473.Peer-Reviewed Original ResearchConceptsIntensive carePandemic influenzaLaboratory-confirmed influenza hospitalizationsBacteremia/sepsisInfluenza-associated complicationsIntensive care requirementAcute renal failurePopulation-based surveillanceSeverity of complicationsMedian hospitalization durationNinth Revision codesInfluenza hospitalizationsAsthma exacerbationsHospitalization durationInfluenza vaccinationRespiratory failureCommon complicationRenal failureBacterial coinfectionProlonged hospitalizationMedian lengthPrimary preventionRevision codesSeasonal influenzaHospitalized children
2011
Association Between Use of Statins and Mortality Among Patients Hospitalized With Laboratory-Confirmed Influenza Virus Infections: A Multistate Study
Vandermeer M, Thomas A, Kamimoto L, Reingold A, Gershman K, Meek J, Farley M, Ryan P, Lynfield R, Baumbach J, Schaffner W, Bennett N, Zansky S. Association Between Use of Statins and Mortality Among Patients Hospitalized With Laboratory-Confirmed Influenza Virus Infections: A Multistate Study. The Journal Of Infectious Diseases 2011, 205: 13-19. PMID: 22170954, DOI: 10.1093/infdis/jir695.Peer-Reviewed Original ResearchConceptsEmerging Infections ProgramLaboratory-confirmed influenzaInfluenza virus infectionVirus infectionPrevention's Emerging Infections ProgramMultivariable logistic regression modelInfluenza-related deathsChronic lung diseaseUse of statinsAdministration of statinsRisk of mortalityLogistic regression modelsProtective oddsHospitalized adultsInfluenza testsInfluenza vaccinationStatin useInfluenza seasonRenal diseaseAntiviral administrationImmunomodulatory effectsLung diseaseActive surveillanceInfections ProgramStatinsSeasonal and 2009 pandemic influenza A (H1N1) virus infection during pregnancy: a population-based study of hospitalized cases
Creanga A, Kamimoto L, Newsome K, D'Mello T, Jamieson D, Zotti M, Arnold K, Baumbach J, Bennett N, Farley M, Gershman K, Kirschke D, Lynfield R, Meek J, Morin C, Reingold A, Ryan P, Schaffner W, Thomas A, Zansky S, Finelli L, Honein M. Seasonal and 2009 pandemic influenza A (H1N1) virus infection during pregnancy: a population-based study of hospitalized cases. American Journal Of Obstetrics And Gynecology 2011, 204: s38-s45. PMID: 21507375, DOI: 10.1016/j.ajog.2011.02.037.Peer-Reviewed Original ResearchConceptsReproductive-aged womenPandemic influenza A (H1N1) virus infectionInfluenza A Virus InfectionA virus infectionPregnant womenPandemic influenzaVirus infectionExact testEmerging Infections ProgramPandemic influenza casesUnderlying medical conditionsPopulation-based studyPopulation-based dataFisher's exact testInfluenza vaccinationNonpregnant womenAntiviral treatmentSeasonal influenzaInfections ProgramInfluenza casesMedical conditionsPregnancyWomenInfluenzaSignificant proportion