2022
Drug use and severe outcomes among adults hospitalized with influenza, 2016–2019
Parisi C, Yousey‐Hindes K, Holstein R, O'Halloran A, Kirley P, Alden N, Anderson E, Kim S, McMahon M, Khanlian S, Spina N, Gaitan M, Shiltz E, Thomas A, Schaffner W, Talbot K, Crossland M, Cook R, Garg S, Meek J, Hadler J. Drug use and severe outcomes among adults hospitalized with influenza, 2016–2019. Influenza And Other Respiratory Viruses 2022, 17: e13052. PMID: 36300969, PMCID: PMC9835414, DOI: 10.1111/irv.13052.Peer-Reviewed Original ResearchConceptsSevere outcomesDrug useICU admissionMechanical ventilationInfluenza Hospitalization Surveillance NetworkInfluenza-associated outcomesSevere influenza outcomesPersistent public health problemChronic liver diseaseChronic lung diseasePublic health problemNon-Hispanic blacksLogistic regression modelsHispanics/LatinosSmoke tobaccoInfluenza vaccinationOpioid useImmunosuppressive conditionsInfluenza seasonSevere morbidityInfluenza infectionInfluenza outcomesLiver diseaseLung diseaseChronic conditions
2017
Causes of In-hospital and Post discharge Mortality Among Patients Hospitalized with Laboratory-Confirmed Influenza, Influenza Hospitalization Surveillance Network, 2014–2015
McGowan C, Arriola C, Cummings C, Kirley P, Miller L, Meek J, Anderson E, Monroe M, Bohm S, McMahon M, Bargsten M, Zansky S, Bennett N, Lung K, Thomas A, Schaffner W, Price A, Dos Santos Chaves S, Reed C, Garg S. Causes of In-hospital and Post discharge Mortality Among Patients Hospitalized with Laboratory-Confirmed Influenza, Influenza Hospitalization Surveillance Network, 2014–2015. Open Forum Infectious Diseases 2017, 4: s24-s24. PMCID: PMC5632265, DOI: 10.1093/ofid/ofx162.061.Peer-Reviewed Original ResearchLaboratory-confirmed influenzaCause of deathDeath certificatesInfluenza-related hospitalizationsPost-discharge mortalityDays post dischargeHalf of deathsIntensive care unitLocation of deathDeath registration systemInfluenza resultsHospital deathClinical characteristicsHospital dischargeIn-HospitalSymptom onsetInfluenza seasonCare unitRespiratory causesDischarge mortalitySeasonal influenzaVaccination ratesCardiovascular diseaseCommon causeHospitalization
2016
Case-Control Study of Vaccine Effectiveness in Preventing Laboratory-Confirmed Influenza Hospitalizations in Older Adults, United States, 2010–2011
Havers F, Sokolow L, Shay D, Farley M, Monroe M, Meek J, Kirley P, Bennett N, Morin C, Aragon D, Thomas A, Schaffner W, Zansky S, Baumbach J, Ferdinands J, Fry A. Case-Control Study of Vaccine Effectiveness in Preventing Laboratory-Confirmed Influenza Hospitalizations in Older Adults, United States, 2010–2011. Clinical Infectious Diseases 2016, 63: 1304-1311. PMID: 27486114, DOI: 10.1093/cid/ciw512.Peer-Reviewed Original ResearchConceptsLaboratory-confirmed influenza hospitalizationsCase-control studyInfluenza hospitalizationsCase patientsAge groupsRecent hospitalizationRespiratory conditionsLower functional status scoresOlder adultsConditional logistic regression modelsAdjusted VE estimatesInfluenza-associated complicationsVaccine effectiveness dataChronic medical conditionsFunctional status scoresMonths of hospitalizationChronic health conditionsLogistic regression modelsPreventing LaboratoryInfluenza vaccinationVaccination statusVaccine effectivenessInfluenza seasonVE estimatesInfluenza infectionBenefit of Early Initiation of Influenza Antiviral Treatment to Pregnant Women Hospitalized With Laboratory-Confirmed Influenza
Oboho I, Reed C, Gargiullo P, Leon M, Aragon D, Meek J, Anderson E, Ryan P, Lynfield R, Morin C, Bargsten M, Zansky S, Fowler B, Thomas A, Lindegren M, Schaffner W, Risk I, Finelli L, Chaves S. Benefit of Early Initiation of Influenza Antiviral Treatment to Pregnant Women Hospitalized With Laboratory-Confirmed Influenza. The Journal Of Infectious Diseases 2016, 214: 507-515. PMID: 26908745, DOI: 10.1093/infdis/jiw033.Peer-Reviewed Original ResearchConceptsInfluenza antiviral treatmentSevere influenzaAntiviral treatmentLength of stayPregnant womenEarly initiationInfluenza vaccinationIntensive care unit admissionAnnual influenza vaccinationCare unit admissionLaboratory-confirmed influenzaUnit admissionPregnancy trimesterPreterm deliveryRespiratory failurePulmonary embolismInfluenza seasonMedian ageSeverity strataMechanical ventilationParametric survival analysisIllness onsetInfant morbidityMedian lengthFetal lossRespiratory Viral Testing and Influenza Antiviral Prescriptions During Hospitalization for Acute Respiratory Illnesses
Rolfes MA, Yousey-Hindes KM, Meek JI, Fry AM, Chaves SS. Respiratory Viral Testing and Influenza Antiviral Prescriptions During Hospitalization for Acute Respiratory Illnesses. Open Forum Infectious Diseases 2016, 3: ofv216. PMID: 26885545, PMCID: PMC4751920, DOI: 10.1093/ofid/ofv216.Peer-Reviewed Original Research
2015
Impact of Prompt Influenza Antiviral Treatment on Extended Care Needs After Influenza Hospitalization Among Community-Dwelling Older Adults
Chaves S, Pérez A, Miller L, Bennett N, Bandyopadhyay A, Farley M, Fowler B, Hancock E, Kirley P, Lynfield R, Ryan P, Morin C, Schaffner W, Sharangpani R, Lindegren M, Tengelsen L, Thomas A, Hill M, Bradley K, Oni O, Meek J, Zansky S, Widdowson M, Finelli L. Impact of Prompt Influenza Antiviral Treatment on Extended Care Needs After Influenza Hospitalization Among Community-Dwelling Older Adults. Clinical Infectious Diseases 2015, 61: 1807-1814. PMID: 26334053, DOI: 10.1093/cid/civ733.Peer-Reviewed Original ResearchConceptsIllness onsetCommunity-dwelling adultsAntiviral treatmentExtended careCare needsEarly treatmentInfluenza hospitalizationsHospital dischargeIntensive care unit admissionLaboratory-confirmed influenza hospitalizationsOlder adultsCommunity-dwelling older adultsInfluenza antiviral treatmentPrompt antiviral treatmentCare unit admissionImpact of influenzaLength of stayRisk survival analysisUnit admissionHospital lengthInfluenza seasonShortens hospitalizationNeurologic disordersRehabilitation facilityAntiviral agentsImproving Accuracy of Influenza-Associated Hospitalization Rate Estimates - Volume 21, Number 9—September 2015 - Emerging Infectious Diseases journal - CDC
Millman A, Reed C, Kirley P, Aragon D, Meek J, Farley M, Ryan P, Collins J, Lynfield R, Baumbach J, Zansky S, Bennett N, Fowler B, Thomas A, Lindegren M, Atkinson A, Finelli L, Chaves S. Improving Accuracy of Influenza-Associated Hospitalization Rate Estimates - Volume 21, Number 9—September 2015 - Emerging Infectious Diseases journal - CDC. Emerging Infectious Diseases 2015, 21: 1595-1601. PMID: 26292017, PMCID: PMC4550134, DOI: 10.3201/eid2109.141665.Peer-Reviewed Original ResearchConceptsYears of ageHospitalization ratesAdults 18Test sensitivityLaboratory-confirmed influenza-associated hospitalizationsNational population-based surveillance systemLaboratory-confirmed influenza hospitalizationsPopulation-based surveillance systemInfectious Diseases journal - CDCInfluenza-associated hospitalizationsDiagnostic test typeFluSurv-NETInfluenza hospitalizationsInfluenza seasonPatient ageAge groupsTranscription-PCRAgeHospitalizationDiagnostic test sensitivitySensitive testAdultsSurveillance systemChildrenYearsDoes Influenza Vaccination Modify Influenza Severity? Data on Older Adults Hospitalized With Influenza During the 2012−2013 Season in the United States
Arriola C, Anderson E, Baumbach J, Bennett N, Bohm S, Hill M, Lindegren M, Lung K, Meek J, Mermel E, Miller L, Monroe M, Morin C, Oni O, Reingold A, Schaffner W, Thomas A, Zansky S, Finelli L, Chaves S. Does Influenza Vaccination Modify Influenza Severity? Data on Older Adults Hospitalized With Influenza During the 2012−2013 Season in the United States. The Journal Of Infectious Diseases 2015, 212: 1200-1208. PMID: 25821227, PMCID: PMC4683374, DOI: 10.1093/infdis/jiv200.Peer-Reviewed Original ResearchConceptsInfluenza vaccinationInfluenza severityDisease severityIntensive care unit admissionMultivariable logistic regression modelSevere influenza outcomesCare unit admissionLaboratory-confirmed influenzaMultivariable logistic regressionDiagnosis of pneumoniaLogistic regression modelsUnit admissionICU lengthVaccine effectivenessInfluenza seasonParametric survival modelsInfluenza outcomesVaccinated personsVaccinationPropensity scoreLogistic regressionOlder adultsPredominant strainSeverityInfluenzaStatin Treatment and Mortality: Propensity Score-Matched Analyses of 2007–2008 and 2009–2010 Laboratory-Confirmed Influenza Hospitalizations
Laidler M, Thomas A, Baumbach J, Kirley P, Meek J, Aragon D, Morin C, Ryan P, Schaffner W, Zansky S, Chaves S. Statin Treatment and Mortality: Propensity Score-Matched Analyses of 2007–2008 and 2009–2010 Laboratory-Confirmed Influenza Hospitalizations. Open Forum Infectious Diseases 2015, 2: ofv028. PMID: 26034777, PMCID: PMC4438907, DOI: 10.1093/ofid/ofv028.Peer-Reviewed Original ResearchPropensity score-matched analysisStatin treatmentAdjunct treatmentInfluenza virus infectionHost inflammatory responseAnnual influenza epidemicsInfluenza hospitalizationsInfluenza seasonSubstantial morbidityHospitalized cohortCox regressionImmunomodulatory agentsInflammatory responseVirus infectionProtective effectInfluenza epidemicsSurveillance dataMortalityUnmeasured confoundersStatinsDeathTreatmentVaccine productionInfluenzaPandemic
2014
Complications Among Adults Hospitalized With Influenza: A Comparison of Seasonal Influenza and the 2009 H1N1 Pandemic
Reed C, Chaves S, Perez A, D'Mello T, Kirley P, Aragon D, Meek J, Farley M, Ryan P, Lynfield R, Morin C, Hancock E, Bennett N, Zansky S, Thomas A, Lindegren M, Schaffner W, Finelli L. Complications Among Adults Hospitalized With Influenza: A Comparison of Seasonal Influenza and the 2009 H1N1 Pandemic. Clinical Infectious Diseases 2014, 59: 166-174. PMID: 24785230, PMCID: PMC7314251, DOI: 10.1093/cid/ciu285.Peer-Reviewed Original ResearchConceptsSeasonal influenzaMedical conditionsLower respiratory tract complicationsRevision discharge diagnosis codesPopulation-based surveillance systemCertain underlying medical conditionsYoung adultsInfluenza-associated complicationsInfluenza-related complicationsShock/sepsisTypical influenza seasonPattern of complicationsRespiratory tract complicationsUnderlying medical conditionsDischarge diagnosis codesChronic medical conditionsIntensive care unitAppropriate clinical managementSevere influenzaNeurologic complicationsInfluenza seasonOrgan failureCare unitMechanical ventilationClinical complications
2012
Reduced Influenza Antiviral Treatment Among Children and Adults Hospitalized With Laboratory-Confirmed Influenza Infection in the Year After the 2009 Pandemic
Garg S, Chaves SS, Pérez A, D'Mello T, Gershman K, Meek J, Yousey-Hindes K, Arnold KE, Farley MM, Tengelsen L, Ryan P, Sharangpani R, Lynfield R, Morin C, Baumbach J, Hancock EB, Zansky S, Bennett NM, Fowler B, Bradley K, Thomas A, Cooper T, Schaffner W, Boulton R, Finelli L, Fry AM. Reduced Influenza Antiviral Treatment Among Children and Adults Hospitalized With Laboratory-Confirmed Influenza Infection in the Year After the 2009 Pandemic. Clinical Infectious Diseases 2012, 55: e18-e21. PMID: 22543024, DOI: 10.1093/cid/cis442.Peer-Reviewed Original ResearchInfluenza-associated Hospitalizations by Industry, 2009–10 Influenza Season, United States - Volume 18, Number 4—April 2012 - Emerging Infectious Diseases journal - CDC
Luckhaupt SE, Sweeney MH, Funk R, Calvert GM, Nowell M, D'Mello T, Reingold A, Meek J, Yousey-Hindes K, Arnold KE, Ryan P, Lynfield R, Morin C, Baumbach J, Zansky S, Bennett NM, Thomas A, Schaffner W, Jones T. Influenza-associated Hospitalizations by Industry, 2009–10 Influenza Season, United States - Volume 18, Number 4—April 2012 - Emerging Infectious Diseases journal - CDC. Emerging Infectious Diseases 2012, 18: 556-562. PMID: 22469504, PMCID: PMC3309704, DOI: 10.3201/eid1804.110337.Peer-Reviewed Original Research
2011
Association Between Use of Statins and Mortality Among Patients Hospitalized With Laboratory-Confirmed Influenza Virus Infections: A Multistate Study
Vandermeer M, Thomas A, Kamimoto L, Reingold A, Gershman K, Meek J, Farley M, Ryan P, Lynfield R, Baumbach J, Schaffner W, Bennett N, Zansky S. Association Between Use of Statins and Mortality Among Patients Hospitalized With Laboratory-Confirmed Influenza Virus Infections: A Multistate Study. The Journal Of Infectious Diseases 2011, 205: 13-19. PMID: 22170954, DOI: 10.1093/infdis/jir695.Peer-Reviewed Original ResearchConceptsEmerging Infections ProgramLaboratory-confirmed influenzaInfluenza virus infectionVirus infectionPrevention's Emerging Infections ProgramMultivariable logistic regression modelInfluenza-related deathsChronic lung diseaseUse of statinsAdministration of statinsRisk of mortalityLogistic regression modelsProtective oddsHospitalized adultsInfluenza testsInfluenza vaccinationStatin useInfluenza seasonRenal diseaseAntiviral administrationImmunomodulatory effectsLung diseaseActive surveillanceInfections ProgramStatinsChildren With Asthma Hospitalized With Seasonal or Pandemic Influenza, 2003–2009
Dawood F, Kamimoto L, D'Mello T, Reingold A, Gershman K, Meek J, Arnold K, Farley M, Ryan P, Lynfield R, Morin C, Baumbach J, Zansky S, Bennett N, Thomas A, Schaffner W, Kirschke D, Finelli L. Children With Asthma Hospitalized With Seasonal or Pandemic Influenza, 2003–2009. Pediatrics 2011, 128: e27-e32. PMID: 21646257, DOI: 10.1542/peds.2010-3343.Peer-Reviewed Original ResearchConceptsPandemic H1N1 influenzaAdditional medical conditionsAsthmatic childrenClinical courseInfluenza seasonH1N1 influenzaMedical conditionsLaboratory-confirmed influenzaAsthma exacerbationsRespiratory failureAsthma severityMedian ageInfluenza BInfluenza preventionIntensive careSeasonal influenzaMedical historyMedical recordsInfluenza AInfluenza typeAsthmaInfluenzaCare occurSubstantial proportionComplications
2010
Adult Hospitalizations for Laboratory-Positive Influenza during the 2005–2006 through 2007–2008 Seasons in the United States
Dao C, Kamimoto L, Nowell M, Reingold A, Gershman K, Meek J, Arnold K, Farley M, Ryan P, Lynfield R, Morin C, Baumbach J, Hancock E, Zansky S, Bennett N, Thomas A, Vandermeer M, Kirschke D, Schaffner W, Finelli L. Adult Hospitalizations for Laboratory-Positive Influenza during the 2005–2006 through 2007–2008 Seasons in the United States. The Journal Of Infectious Diseases 2010, 202: 881-888. PMID: 20677944, DOI: 10.1086/655904.Peer-Reviewed Original ResearchConceptsInfluenza-associated hospitalizationsInfluenza seasonEmerging Infections Program NetworkEmerging Infections Program sitesHospitalization discharge diagnosesInfections Program NetworkInfluenza-associated complicationsRate of hospitalizationLaboratory-positive casesAge-specific ratesTypes/subtypesAdult hospitalizationsHospitalization surveillanceClinical characteristicsInfluenza B.Discharge diagnosisMedical conditionsHospitalizationMetabolic diseasesIncreased circulationInfluenza virusOverall rateInfluenzaPredominant seasonsAgeInfluenza-Associated Pneumonia in Children Hospitalized With Laboratory-Confirmed Influenza, 2003–2008
Dawood FS, Fiore A, Kamimoto L, Nowell M, Reingold A, Gershman K, Meek J, Hadler J, Arnold KE, Ryan P, Lynfield R, Morin C, Baumbach J, Zansky S, Bennett NM, Thomas A, Schaffner W, Kirschke D, Finelli L. Influenza-Associated Pneumonia in Children Hospitalized With Laboratory-Confirmed Influenza, 2003–2008. The Pediatric Infectious Disease Journal 2010, 29: 585-590. PMID: 20589966, PMCID: PMC5856105, DOI: 10.1097/inf.0b013e3181d411c5.Peer-Reviewed Original ResearchConceptsInfluenza-associated pneumoniaChest radiographsHospitalized childrenIntensive care unit admissionCare unit admissionLaboratory-confirmed influenzaSevere clinical courseInfluenza complicationsUnit admissionRespiratory failureCommon complicationClinical courseInfluenza seasonTreatment strategiesPneumoniaMultivariate analysisNew pneumoniaGreater riskInfluenzaRadiographsAge 6Age 2HospitalizationAsthmaComplicationsInfluenza Testing and Antiviral Prescribing Practices Among Emergency Department Clinicians in 9 States During the 2006 to 2007 Influenza Season
Mueller M, Smith P, Baumbach J, Palumbo J, Meek J, Gershman K, Vandermeer M, Thomas A, Long C, Belflower R, Spina N, Martin K, Lynfield R, Openo K, Kirley P, Pasutti L, Barnes B, Schaffner W, Kamimoto L. Influenza Testing and Antiviral Prescribing Practices Among Emergency Department Clinicians in 9 States During the 2006 to 2007 Influenza Season. Annals Of Emergency Medicine 2010, 55: 32-39. PMID: 20116012, DOI: 10.1016/j.annemergmed.2009.09.019.Peer-Reviewed Original ResearchConceptsEmergency department cliniciansInfluenza testingAntiviral medicationsInfluenza seasonED cliniciansClinician testingTreatment decisionsEmerging Infections Program NetworkTreatment practicesInfections Program NetworkInfluenza-associated hospitalizationsType of hospitalFirst-line providersInfluenza medicationsAntiviral useTreatment guidelinesHospital EDPrescribing practicesHospital testingInfluenza diseaseActive surveillanceClinical guidelinesClinicians' perceptionsHospital typeMedications