2012
Effects of Ketamine in Treatment-Refractory Obsessive-Compulsive Disorder
Bloch MH, Wasylink S, Landeros-Weisenberger A, Panza KE, Billingslea E, Leckman JF, Krystal JH, Bhagwagar Z, Sanacora G, Pittenger C. Effects of Ketamine in Treatment-Refractory Obsessive-Compulsive Disorder. Biological Psychiatry 2012, 72: 964-970. PMID: 22784486, PMCID: PMC3667652, DOI: 10.1016/j.biopsych.2012.05.028.Peer-Reviewed Original ResearchConceptsObsessive-compulsive disorderKetamine infusionDepression symptomsLow-dose ketamine infusionTreatment-refractory obsessive-compulsive disorderOCD symptomsPathogenesis of OCDIncomplete symptom reliefTreatment-Refractory ObsessiveOpen-label trialRapid antidepressant effectsAspartate glutamate receptorsEffects of ketaminePotent noncompetitive antagonistGlutamate abnormalitiesAntidepressant effectsAntidepressant responseSymptom reliefKetamine effectsComorbid depressionAcute effectsGlutamate receptorsDepressive symptomsNoncompetitive antagonistInfusion
2005
Antidepressant‐Induced Manic Conversion: A Developmentally Informed Synthesis of the Literature
Lim CJ, Leckman JF, Young C, Martin A. Antidepressant‐Induced Manic Conversion: A Developmentally Informed Synthesis of the Literature. International Review Of Neurobiology 2005, 65: 25-52. PMID: 16140052, DOI: 10.1016/s0074-7742(04)65002-1.Peer-Reviewed Original ResearchConceptsAddition of antidepressantsResolution of symptomsAntidepressant-induced maniaSerotonin reuptake inhibitorsMood stabilizer therapyLess nursing careMost case reportsRapid cyclingManic conversionSpontaneous maniaAntidepressant medicationReuptake inhibitorsAntidepressant exposureBipolar depressionCase reportManic episodesMood destabilizationSpontaneous episodesDistressing conditionSevere depressionClinical recommendationsManic symptomsNursing careSelective SSRIPatient screening
2004
Age Effects on Antidepressant-Induced Manic Conversion
Martin A, Young C, Leckman JF, Mukonoweshuro C, Rosenheck R, Leslie D. Age Effects on Antidepressant-Induced Manic Conversion. JAMA Pediatrics 2004, 158: 773-780. PMID: 15289250, DOI: 10.1001/archpedi.158.8.773.Peer-Reviewed Original ResearchConceptsManic conversionAntidepressant classesPatient ageTime-dependent Cox proportional hazards modelsSelective serotonin reuptake inhibitorsCox proportional hazards modelNonbipolar mood disorderSerotonin reuptake inhibitorsProportional hazards modelRisk of conversionAdministrative national databaseEffect of agePharmacy claimsReuptake inhibitorsAntidepressant exposureDrug therapyTricyclic antidepressantsPeripubertal childrenAge effectsBipolar illnessMood disordersHigh riskMental health usersAntidepressant categoryHazards model