2018
A multicenter examination and strategic revisions of the Yale Global Tic Severity Scale
McGuire JF, Piacentini J, Storch EA, Murphy TK, Ricketts EJ, Woods DW, Walkup JW, Peterson AL, Wilhelm S, Lewin AB, McCracken JT, Leckman JF, Scahill L. A multicenter examination and strategic revisions of the Yale Global Tic Severity Scale. Neurology 2018, 90: e1711-e1719. PMID: 29653992, PMCID: PMC5952973, DOI: 10.1212/wnl.0000000000005474.Peer-Reviewed Original ResearchConceptsTic symptom severityTic scoreTIC numbersYale Global Tic Severity Scale (YGTSS) scoresSymptom severityYale Global Tic Severity ScaleYGTSS total tic scoreTotal tic scoreSimilar clinical characteristicsInternal consistencySeverity Scale scoreCross-sectional studyTic Severity ScaleDelphi consensus processClinical characteristicsPhonic ticsTic disordersMulticenter examinationImpairment scoresGood internal consistencySeverity ScaleScale scoreSymptom ChecklistDiagnostic InterviewStrong internal consistency
2012
Behavioral, Pharmacological, and Immunological Abnormalities after Streptococcal Exposure: A Novel Rat Model of Sydenham Chorea and Related Neuropsychiatric Disorders
Brimberg L, Benhar I, Mascaro-Blanco A, Alvarez K, Lotan D, Winter C, Klein J, Moses AE, Somnier FE, Leckman JF, Swedo SE, Cunningham MW, Joel D. Behavioral, Pharmacological, and Immunological Abnormalities after Streptococcal Exposure: A Novel Rat Model of Sydenham Chorea and Related Neuropsychiatric Disorders. Neuropsychopharmacology 2012, 37: 2076-2087. PMID: 22534626, PMCID: PMC3398718, DOI: 10.1038/npp.2012.56.Peer-Reviewed Original ResearchConceptsSydenham's choreaNeuropsychiatric disordersStreptococcal exposureImmunological abnormalitiesMotor symptomsRat modelAnimal modelsSelective serotonin reuptake inhibitor paroxetineGroup A streptococcal infectionsSerotonin reuptake inhibitor paroxetineSK-N-SH neuronal cellsMale Lewis ratsNovel rat modelNew animal modelCalcium/calmodulin-dependent protein kinase IIRelated neuropsychiatric disordersStreptococcal infectionLewis ratsAntibody depositionBasal gangliaCalmodulin-dependent protein kinase IIDopamine D1GAS antigensGlutamate levelsD2 receptors
1993
Severe disturbances in speech, swallowing, and gait following stereotactic infrathalamic lesions in Gilles de la Tourette's syndrome.
Leckman JF, de Lotbinière A, Marek K, Gracco C, Scahill L, Cohen DJ. Severe disturbances in speech, swallowing, and gait following stereotactic infrathalamic lesions in Gilles de la Tourette's syndrome. Neurology 1993, 43: 890-4. PMID: 8492943, DOI: 10.1212/wnl.43.5.890.Peer-Reviewed Original ResearchConceptsGilles de la Tourette's syndromeLa Tourette's syndromeLow-density areasMotor ticsTourette syndromeLast surgical procedureSevere gait disturbanceAnterior cingulate gyrusBilateral anterior cingulotomyGait disturbanceNeurologic deficitsObsessive-compulsive disorderSwallowing disordersAnterior cingulotomyPhonic ticsPostural instabilitySurgical proceduresCingulate gyrusObsessive-compulsive symptomsSyndromeNeurosurgical proceduresPatient's speechPatientsLesionsSecond procedure