2008
Consanguineous Iranian kindreds with severe Tourette syndrome
Motlagh MG, Seddigh A, Dashti B, Leckman JF, Alaghband‐Rad J. Consanguineous Iranian kindreds with severe Tourette syndrome. Movement Disorders 2008, 23: 2079-2083. PMID: 18785237, PMCID: PMC3972002, DOI: 10.1002/mds.22261.Peer-Reviewed Original Research
2006
A Primary Candidate Gene for Obsessive-compulsive Disorder
Leckman JF, Kim YS. A Primary Candidate Gene for Obsessive-compulsive Disorder. JAMA Psychiatry 2006, 63: 717-720. PMID: 16818860, DOI: 10.1001/archpsyc.63.7.717.Peer-Reviewed Original Research
2005
Sequence Variants in SLITRK1 Are Associated with Tourette's Syndrome
Abelson JF, Kwan KY, O'Roak BJ, Baek DY, Stillman AA, Morgan TM, Mathews CA, Pauls DL, Rašin M, Gunel M, Davis NR, Ercan-Sencicek AG, Guez DH, Spertus JA, Leckman JF, Dure LS, Kurlan R, Singer HS, Gilbert DL, Farhi A, Louvi A, Lifton RP, Šestan N, State MW. Sequence Variants in SLITRK1 Are Associated with Tourette's Syndrome. Science 2005, 310: 317-320. PMID: 16224024, DOI: 10.1126/science.1116502.Peer-Reviewed Original ResearchMeSH Keywords3' Untranslated RegionsAdolescentAnimalsAttention Deficit Disorder with HyperactivityBrainChildChild, PreschoolChromosome InversionChromosome MappingChromosomes, Human, Pair 13DNADNA Mutational AnalysisFemaleFrameshift MutationHumansIn Situ Hybridization, FluorescenceMaleMembrane ProteinsMiceMutationNerve Tissue ProteinsPedigreeSequence Analysis, DNATourette SyndromeConceptsSequence variantsTourette syndromeChromosomal inversionsFrameshift mutantsCandidate genesExpression patternsControl chromosomesPrimary neuronal culturesFrameshift mutationSLITRK1Independent occurrenceMotor ticsDevelopmental neuropsychiatric disordersChronic vocalNeuronal culturesIdentical variantsUnrelated probandsBrain regionsNeuropsychiatric disordersSyndrome
2003
Epigenetic abnormalities associated with a chromosome 18(q21-q22) inversion and a Gilles de la Tourette syndrome phenotype
State MW, Greally JM, Cuker A, Bowers PN, Henegariu O, Morgan TM, Gunel M, DiLuna M, King RA, Nelson C, Donovan A, Anderson GM, Leckman JF, Hawkins T, Pauls DL, Lifton RP, Ward DC. Epigenetic abnormalities associated with a chromosome 18(q21-q22) inversion and a Gilles de la Tourette syndrome phenotype. Proceedings Of The National Academy Of Sciences Of The United States Of America 2003, 100: 4684-4689. PMID: 12682296, PMCID: PMC153616, DOI: 10.1073/pnas.0730775100.Peer-Reviewed Original Research
1991
Progress in the search for genetic linkage with Tourette syndrome: an exclusion map covering more than 50% of the autosomal genome.
Pakstis AJ, Heutink P, Pauls DL, Kurlan R, van de Wetering BJ, Leckman JF, Sandkuyl LA, Kidd JR, Breedveld GJ, Castiglione CM. Progress in the search for genetic linkage with Tourette syndrome: an exclusion map covering more than 50% of the autosomal genome. American Journal Of Human Genetics 1991, 48: 281-94. PMID: 1990837, PMCID: PMC1683024.Peer-Reviewed Original Research
1990
Gilles de La Tourette's syndrome and some forms of obsessive-compulsive disorder may share a common genetic diathesis.
Leckman JF, Chittenden EH. Gilles de La Tourette's syndrome and some forms of obsessive-compulsive disorder may share a common genetic diathesis. L Encéphale 1990, 16 Spec No: 321-3. PMID: 2209489.Peer-Reviewed Original ResearchConceptsPathophysiology of TSGilles de la Tourette's syndromeObsessive-compulsive disorderLa Tourette's syndromeTourette syndromeOCD patientsCerebrospinal fluid studiesRecent neuropathological studiesEndogenous opioid peptidesMesocortical dopaminergic systemCases of OCDCSF dynorphinNeuropathological studiesCommon genetic diathesisRaphe nucleusBasal gangliaSerotoninergic systemSerotonergic systemClinical studiesDopaminergic systemCommon neural substrateTS patientsNeuropharmacological studiesOpioid peptidesNormal controls