2017
Clinical Management of Pediatric Acute-Onset Neuropsychiatric Syndrome: Part I—Psychiatric and Behavioral Interventions
Thienemann M, Murphy T, Leckman J, Shaw R, Williams K, Kapphahn C, Frankovich J, Geller D, Bernstein G, Chang K, Elia J, Swedo S. Clinical Management of Pediatric Acute-Onset Neuropsychiatric Syndrome: Part I—Psychiatric and Behavioral Interventions. Journal Of Child And Adolescent Psychopharmacology 2017, 27: 566-573. PMID: 28722481, PMCID: PMC5610394, DOI: 10.1089/cap.2016.0145.Peer-Reviewed Original ResearchConceptsPediatric acute-onset neuropsychiatric syndromeNeuropsychiatric syndromeInitial treatment doseEvidence-based interventionsPANDAS patientsImmunomodulatory therapyStreptococcal infectionChronic stageSymptomatic treatmentPsychopharmacologic interventionsPsychopharmacologic treatmentSymptom improvementSyndrome AssociatedConsensus guidelinesPsychotropic medicationsClinical managementInflammatory processCurrent guidelinesGuideline SeriesTreatment doseClinical experienceBehavioral symptomsVaried symptomsTherapeutic interventionsBehavioral interventions
2014
Disordered Eating and Food Restrictions in Children with PANDAS/PANS
Toufexis MD, Hommer R, Gerardi DM, Grant P, Rothschild L, D'Souza P, Williams K, Leckman J, Swedo SE, Murphy TK. Disordered Eating and Food Restrictions in Children with PANDAS/PANS. Journal Of Child And Adolescent Psychopharmacology 2014, 25: 48-56. PMID: 25329522, PMCID: PMC4340640, DOI: 10.1089/cap.2014.0063.Peer-Reviewed Original ResearchConceptsPediatric acute-onset neuropsychiatric syndromeClinical presentationRestrictive food intake disorderFood intake disorderFear of chokingSymptom onsetMale predominanceNeuropsychiatric symptomsNeuropsychiatric syndromeSudden onsetFood intakeFood refusalDiagnostic criteriaFood restrictionMental disordersYounger ageBody image distortionStreptococcal bacteriaStatistical ManualSymptomsTreatment implicationsDisordersPresentationSensory issuesChildren
2004
Prospective Longitudinal Study of Children With Tic Disorders and/or Obsessive-Compulsive Disorder: Relationship of Symptom Exacerbations to Newly Acquired Streptococcal Infections
Luo F, Leckman JF, Katsovich L, Findley D, Grantz H, Tucker DM, Lombroso PJ, King RA, Bessen DE. Prospective Longitudinal Study of Children With Tic Disorders and/or Obsessive-Compulsive Disorder: Relationship of Symptom Exacerbations to Newly Acquired Streptococcal Infections. Pediatrics 2004, 113: e578-e585. PMID: 15173540, DOI: 10.1542/peds.113.6.e578.Peer-Reviewed Original ResearchConceptsGABHS infectionSymptom exacerbationObsessive-compulsive disorderControl subjectsTourette syndromeAcute exacerbationTime pointsHealthy control subjectsBeta-hemolytic streptococciAcute inflammatory responseAcute symptom exacerbationsProspective longitudinal studyAutoimmune mechanismsPediatric patientsStreptococcal infectionNeuropsychiatric symptomsGABHS infectionsNonspecific markerInflammatory responseTic disordersUnselected groupObsessive-compulsive symptom severityExacerbationPatientsObsessive-compulsive symptoms
2002
Characteristics of acute stress symptoms and nitric oxide concentration in young rescue workers in Taiwan
Yeh CB, Leckman J, Wan FJ, Shiah IS, Lu RB. Characteristics of acute stress symptoms and nitric oxide concentration in young rescue workers in Taiwan. Psychiatry Research 2002, 112: 59-68. PMID: 12379451, DOI: 10.1016/s0165-1781(02)00179-8.Peer-Reviewed Original ResearchConceptsAcute stress disorderYoung military personnelControl groupMale military personnelNitric oxideInitial evaluationMilitary personnelPoint prevalence ratesAcute stress symptomsDSM-IV criteriaSignificant inverse correlationStress symptomsNitric oxide concentrationPlasma concentrationsPlasma measuresPrevalence ratesRelated syndromesNeuropsychological interviewStress disorderInverse correlationPlasma samplesLongitudinal studyPotential roleRescue workersDisaster workers