2015
Mortality in children, adolescents, and adults with attention deficit hyperactivity disorder: a nationwide cohort study
Dalsgaard S, Østergaard SD, Leckman JF, Mortensen PB, Pedersen MG. Mortality in children, adolescents, and adults with attention deficit hyperactivity disorder: a nationwide cohort study. The Lancet 2015, 385: 2190-2196. PMID: 25726514, DOI: 10.1016/s0140-6736(14)61684-6.Peer-Reviewed Original ResearchMeSH KeywordsAccidentsAdolescentAdultAge of OnsetAttention Deficit and Disruptive Behavior DisordersAttention Deficit Disorder with HyperactivityCase-Control StudiesCause of DeathChildChild, PreschoolConduct DisorderCross-Sectional StudiesDenmarkFemaleHumansInfantMalePoisson DistributionRisk FactorsSubstance-Related DisordersYoung AdultConceptsMortality rate ratiosAttention deficit hyperactivity disorderHighest mortality rate ratiosSubstance use disordersOppositional defiant disorderDeficit hyperactivity disorderExcess mortalityConduct disorderUse disordersMortality rateDefiant disorderHyperactivity disorderNationwide cohort studyDanish national registersCommon mental disordersExclusion of individualsCohort studyLundbeck FoundationCommon causeFamily historyCohort membersLarge cohortPsychiatric disordersUnnatural causesDanish individuals
2012
Trajectory in obsessive-compulsive disorder comorbidities
de Mathis MA, Diniz JB, Hounie AG, Shavitt RG, Fossaluza V, Ferrão Y, Leckman JF, de Bragança Pereira C, do Rosario MC, Miguel EC. Trajectory in obsessive-compulsive disorder comorbidities. European Neuropsychopharmacology 2012, 23: 594-601. PMID: 22921470, DOI: 10.1016/j.euroneuro.2012.08.006.Peer-Reviewed Original ResearchConceptsObsessive-compulsive disorderHigher lifetime frequencyOCD patientsFirst diagnosisTic disordersSeparation anxiety disorderLifetime frequencyObsessive-compulsive disorder (OCD) comorbidityAnxiety disordersOnset of OCDDistribution of comorbiditiesSpecific comorbid diagnosesLifetime psychiatric diagnosesPost-traumatic stress disorderFirst comorbiditySymptom onsetClinical courseClinical presentationPsychiatric comorbidityDisorder comorbidityOCD courseBeck AnxietyComorbid disordersPsychiatric disordersComorbidities
2011
The familial association of tourette's disorder and ADHD: The impact of OCD symptoms
O'Rourke JA, Scharf JM, Platko J, Stewart SE, Illmann C, Geller DA, King RA, Leckman JF, Pauls DL. The familial association of tourette's disorder and ADHD: The impact of OCD symptoms. American Journal Of Medical Genetics Part B Neuropsychiatric Genetics 2011, 156: 553-560. PMID: 21557467, PMCID: PMC3292860, DOI: 10.1002/ajmg.b.31195.Peer-Reviewed Original Research
2009
Predictors of Early Adult Outcomes in Pediatric-Onset Obsessive-Compulsive Disorder
Bloch MH, Craiglow BG, Landeros-Weisenberger A, Dombrowski PA, Panza KE, Peterson BS, Leckman JF. Predictors of Early Adult Outcomes in Pediatric-Onset Obsessive-Compulsive Disorder. Pediatrics 2009, 124: 1085-1093. PMID: 19786445, PMCID: PMC3974608, DOI: 10.1542/peds.2009-0015.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAdultAge DistributionAge of OnsetChildChild, PreschoolCohort StudiesDisease ProgressionFemaleFollow-Up StudiesHumansIncidenceLongitudinal StudiesMaleMonitoring, PhysiologicMultivariate AnalysisObsessive-Compulsive DisorderPredictive Value of TestsProportional Hazards ModelsRisk FactorsSeverity of Illness IndexSex DistributionTic DisordersTime FactorsTourette SyndromeYoung AdultConceptsObsessive-compulsive disorderOCD symptomsBaseline clinical characteristicsPediatric-onset obsessive-compulsive disorderPersistent obsessive-compulsive disorderEarly adult outcomesLong-term outcomesMain outcome measuresLongitudinal cohort studyPercent of subjectsComorbid tic disordersOC symptomsHoarding symptomsAdult outcomesExperience remissionClinical characteristicsClinical predictorsCohort studyOppositional defiant disorderTic symptomsComorbid ticsEligible childrenTic disordersFemale genderOutcome measuresValidation of the University of São Paulo Sensory Phenomena Scale:Initial Psychometric Properties
Rosario MC, Prado HS, Borcato S, Diniz JB, Shavitt RG, Hounie AG, Mathis ME, Mastrorosa RS, Velloso P, Perin EA, Fossaluza V, Pereira CA, Geller D, Leckman J, Miguel E. Validation of the University of São Paulo Sensory Phenomena Scale:Initial Psychometric Properties. CNS Spectrums 2009, 14: 315-323. PMID: 19668122, DOI: 10.1017/s1092852900020319.Peer-Reviewed Original ResearchConceptsOpen clinical interviewClinical InterviewYale-Brown ObsessiveObsessive-compulsive disorderFourth Edition Axis I DisordersEarly-onset OCD patientsYale Global Tic Severity ScaleSensory phenomenaCompulsive ScaleOCD patientsOCD subjectsAxis I DisordersTic Severity ScaleSão Paulo Sensory Phenomena ScaleSignificant differencesBeck Depression InventoryBeck Anxiety InventorySeverity scoreI disordersInter-rater reliabilityInitial psychometric propertiesSeverity ScalePremonitory urgesPatientsDepression InventorySymptom dimensions and subtypes of obsessive-compulsive disorder: a developmental perspective
Leckman JF, Bloch MH, King RA. Symptom dimensions and subtypes of obsessive-compulsive disorder: a developmental perspective. Dialogues In Clinical Neuroscience 2009, 11: 21-33. PMID: 19432385, PMCID: PMC3181902, DOI: 10.31887/dcns.2009.11.1/jfleckman.Peer-Reviewed Original ResearchPerfectionism and sensory phenomena: phenotypic components of obsessive-compulsive disorder
Lee JC, Prado HS, Diniz JB, Borcato S, da Silva CB, Hounie AG, Miguel EC, Leckman JF, do Rosário MC. Perfectionism and sensory phenomena: phenotypic components of obsessive-compulsive disorder. Comprehensive Psychiatry 2009, 50: 431-436. PMID: 19683613, DOI: 10.1016/j.comppsych.2008.11.007.Peer-Reviewed Original Research
2008
Editorial: A global perspective on child and adolescent mental health
Leckman JF, Leventhal BL. Editorial: A global perspective on child and adolescent mental health. Journal Of Child Psychology And Psychiatry 2008, 49: 221-225. PMID: 18333928, DOI: 10.1111/j.1469-7610.2008.01884.x.Peer-Reviewed Original Research
2006
Decreased Numbers of Regulatory T Cells Suggest Impaired Immune Tolerance in Children with Tourette Syndrome: A Preliminary Study
Kawikova I, Leckman JF, Kronig H, Katsovich L, Bessen DE, Ghebremichael M, Bothwell AL. Decreased Numbers of Regulatory T Cells Suggest Impaired Immune Tolerance in Children with Tourette Syndrome: A Preliminary Study. Biological Psychiatry 2006, 61: 273-278. PMID: 16996487, DOI: 10.1016/j.biopsych.2006.06.012.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAge of OnsetAntigens, CDAntigens, Differentiation, T-LymphocyteAutoantigensBlood Cell CountCD4 Lymphocyte CountCD8-Positive T-LymphocytesChildData Interpretation, StatisticalFemaleFlow CytometryHumansImmune ToleranceInterleukin-2 Receptor alpha SubunitLectins, C-TypeLymphocyte CountMaleStreptococcal InfectionsTic DisordersT-LymphocytesTourette SyndromeConceptsT reg cellsRegulatory T cellsReg cellsTourette syndromeT cellsTS patientsFluorescence-activated cell sortingHealthy age-matched control childrenHealthy age-matched control subjectsT reg cell numbersBeta-hemolytic streptococcal infectionAge-matched control subjectsHost T-cell immunityPathogenesis of TSHemolytic streptococcal infectionT cell immunitySignificant decreaseAge-matched control childrenAutoimmune inflammationCell immunityStreptococcal infectionAutoreactive lymphocytesImmune toleranceAutoimmune responsePeripheral blood
2005
A family study of early‐onset obsessive‐compulsive disorder
do Rosario‐Campos M, Leckman JF, Curi M, Quatrano S, Katsovitch L, Miguel EC, Pauls DL. A family study of early‐onset obsessive‐compulsive disorder. American Journal Of Medical Genetics Part B Neuropsychiatric Genetics 2005, 136B: 92-97. PMID: 15892140, DOI: 10.1002/ajmg.b.30149.Peer-Reviewed Original ResearchConceptsObsessive-compulsive disorderRecurrence riskChronic ticsFirst-degree family membersChildhood-onset obsessive-compulsive disorderDiagnosis of OCDChronic tic disorderStandardized semi-structured interviewFirst-degree relativesEarly-onset casesOnset obsessive-compulsive disorderDSM-IV criteriaEarly-onset obsessive-compulsive disorderBest-estimate processRandom digit dialingHigh comorbid ratesAge of onsetFamily studiesHigh genetic loadingMean ageSpecialty clinicTic disordersComorbid ratesValid subgroupsCase relatives
2003
Influence of Age and Tic Disorders on Obsessive-Compulsive Disorder in a Pediatric Sample
Scahill L, Kano Y, King RA, Carlson A, Peller A, LeBrun U, do Rosario-Campos MC, Leckman JF. Influence of Age and Tic Disorders on Obsessive-Compulsive Disorder in a Pediatric Sample. Journal Of Child And Adolescent Psychopharmacology 2003, 13: 7-17. PMID: 12880496, DOI: 10.1089/104454603322126304.Peer-Reviewed Original ResearchConceptsObsessive-compulsive disorderTic disordersAge of onsetAge groupsPediatric samplesAbsence of ticsHistory of ticsAdolescent age groupImpact of ageInfluence of agePresence of ticsMean ageFunctional statusOnly significant differenceSpecialty clinicSymptom profilesHeterogeneous disorderImportant subgroupSymptom typeDisordersCommon compulsionsAge categoriesCompulsive disorderAgeConvenient sample
2000
The Psychiatric Symptoms of Rheumatic Fever
Mercadante MT, Busatto GF, Lombroso PJ, Prado L, Rosário-Campos MC, do Valle R, Marques-Dias MJ, Kiss MH, Leckman JF, Miguel EC. The Psychiatric Symptoms of Rheumatic Fever. American Journal Of Psychiatry 2000, 157: 2036-2038. PMID: 11097972, DOI: 10.1176/appi.ajp.157.12.2036.Peer-Reviewed Original ResearchConceptsAttention deficit hyperactivity disorderRheumatic feverSydenham's choreaTic disordersHigh riskComparison groupFever groupMajor depressive disorderDeficit hyperactivity disorderObsessive-compulsive disorderDepressive disorderRisk factorsPsychiatric symptomsPsychiatric disordersChoreaFeverNeuropsychiatric disordersObsessive-compulsive symptomsRating ScaleHyperactivity disorderSymptomsDisordersADHD symptomsChildrenSemistructured interviews
1999
Incremental Progress in Developmental Psychopathology: Simply Complex
Leckman JF. Incremental Progress in Developmental Psychopathology: Simply Complex. American Journal Of Psychiatry 1999, 156: 1495-1498. PMID: 10518156, DOI: 10.1176/ajp.156.10.1495.Peer-Reviewed Original Research
1995
A family study of obsessive-compulsive disorder
Pauls DL, Alsobrook JP, Goodman W, Rasmussen S, Leckman JF. A family study of obsessive-compulsive disorder. American Journal Of Psychiatry 1995, 152: 76-84. PMID: 7802125, DOI: 10.1176/ajp.152.1.76.Peer-Reviewed Original ResearchConceptsFirst-degree relativesObsessive-compulsive disorderComparison subjectsSubthreshold obsessive-compulsive disorderAvailable first-degree relativesGilles de la Tourette's syndromeRelatives of probandsLa Tourette's syndromeFamily studiesBest-estimate diagnosesRate of ticsTic disordersFamily historyHigh riskTourette syndromeChronic ticsFemale probandsEarly onsetFamilial typeDisordersUnaffected subjectsProbandsSyndromeStructured interviewsSubjects
1994
"Just right" perceptions associated with compulsive behavior in Tourette's syndrome
Leckman JF, Walker DE, Goodman WK, Pauls DL, Cohen DJ. "Just right" perceptions associated with compulsive behavior in Tourette's syndrome. American Journal Of Psychiatry 1994, 151: 675-680. PMID: 8166308, DOI: 10.1176/ajp.151.5.675.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAdultAge of OnsetAgedAwarenessBasal GangliaChildComorbidityCompulsive BehaviorCross-Sectional StudiesFemaleHumansMaleMiddle AgedObsessive BehaviorObsessive-Compulsive DisorderPerceptionPersonality InventoryPsychiatric Status Rating ScalesSensationSeverity of Illness IndexTourette SyndromeConceptsTic disordersObsessive-compulsive disorderTourette syndromeObsessive-compulsive symptomsCompulsive behaviorsCross-sectional studyYale-Brown Obsessive Compulsive ScaleObsessive Compulsive ScaleTic symptomsChronic disordersPhonic ticsChildhood onsetEpidemiological studiesSyndromeAdult subjectsBrain regionsSymptomsCompulsive ScaleDisordersSensorimotor informationSubjectsThree-quartersCompulsive actsPathobiologySeverityHaloperidol Addition in Fluvoxamine-Refractory Obsessive-Compulsive Disorder: A Double-blind, Placebo-Controlled Study in Patients With and Without Tics
McDougle CJ, Goodman WK, Leckman JF, Lee NC, Heninger GR, Price LH. Haloperidol Addition in Fluvoxamine-Refractory Obsessive-Compulsive Disorder: A Double-blind, Placebo-Controlled Study in Patients With and Without Tics. JAMA Psychiatry 1994, 51: 302-308. PMID: 8161290, DOI: 10.1001/archpsyc.1994.03950040046006.Peer-Reviewed Original ResearchConceptsComorbid chronic tic disorderChronic tic disorderYale-Brown Obsessive Compulsive ScaleObsessive-compulsive disorderTic disordersFluvoxamine treatmentOCD patientsClinical Global Impression ScalePlacebo-treated groupDouble-blind fashionWeeks of treatmentGlobal Impression ScaleTreatment of patientsHaloperidol-treated groupEffective symptom reductionObsessive Compulsive ScaleNeuroleptic therapyBlood levelsImpression ScaleTreatment outcomesTreatment responseAdequate treatmentPatientsPlaceboSymptom reduction