2018
DNA methylome variation in a perinatal nurse-visitation program that reduces child maltreatment: a 27-year follow-up
O’Donnell K, Chen L, MacIsaac JL, McEwen LM, Nguyen T, Beckmann K, Zhu Y, Chen LM, Brooks-Gunn J, Goldman D, Grigorenko EL, Leckman JF, Diorio J, Karnani N, Olds DL, Holbrook JD, Kobor MS, Meaney MJ. DNA methylome variation in a perinatal nurse-visitation program that reduces child maltreatment: a 27-year follow-up. Translational Psychiatry 2018, 8: 15. PMID: 29317599, PMCID: PMC5802588, DOI: 10.1038/s41398-017-0063-9.Peer-Reviewed Original ResearchConceptsNurse-Family PartnershipIntervention programsProspective longitudinal studyYears of ageMajor psychiatric disordersAge 27 yearsChild maltreatmentPsychosocial intervention programEarly intervention programsLifestyle factorsIntervention groupBlood samplesPsychiatric disordersAdult offspringDiagnostic InterviewChildhood adversityNFP programInterindividual variationLongitudinal studyComponent scoresSustained impactAbuse/neglectDNA methylationFamily partnershipsDNA methylome
2017
Longitudinal outcomes of children with pediatric autoimmune neuropsychiatric disorder associated with streptococcal infections (PANDAS)
Leon J, Hommer R, Grant P, Farmer C, D’Souza P, Kessler R, Williams K, Leckman JF, Swedo S. Longitudinal outcomes of children with pediatric autoimmune neuropsychiatric disorder associated with streptococcal infections (PANDAS). European Child & Adolescent Psychiatry 2017, 27: 637-643. PMID: 29119300, DOI: 10.1007/s00787-017-1077-9.Peer-Reviewed Original ResearchConceptsPediatric autoimmune neuropsychiatric disordersAutoimmune neuropsychiatric disordersIntravenous immunoglobulinStreptococcal infectionDose of IVIGNeuropsychiatric disordersPlacebo-controlled trialSignificant obsessive-compulsive symptomsPopulation of childrenCognitive behavioral therapySubacute illnessSydenham's choreaBlinded infusionChronic coursePsychiatric medicationsTreatment modalitiesSpecific symptomsChildhood-onset OCDLongitudinal courseNatural historyObsessive-compulsive symptomsBehavioral therapyExacerbationParents of participantsTelephone interviews
2015
Effect of drugs on the risk of injuries in children with attention deficit hyperactivity disorder: a prospective cohort study
Dalsgaard S, Leckman JF, Mortensen PB, Nielsen HS, Simonsen M. Effect of drugs on the risk of injuries in children with attention deficit hyperactivity disorder: a prospective cohort study. The Lancet Psychiatry 2015, 2: 702-709. PMID: 26249301, DOI: 10.1016/s2215-0366(15)00271-0.Peer-Reviewed Original ResearchConceptsAge 10 yearsAttention deficit hyperactivity disorderAge 12 yearsRisk of injuryPrevalence of injuriesCommon causeDeficit hyperactivity disorderPharmacological treatmentEmergency wardOdds ratioADHD drugsMajor public health importanceEmergency ward visitsHyperactivity disorderProspective cohort studyDanish national registersNon-treated childrenLarge disease burdenPublic health importanceEffects of drugsCohort studyWard visitsUntreated childrenAdjusted differenceDisease burdenMaternal History of Autoimmune Disease and Later Development of Tourette Syndrome in Offspring
Dalsgaard S, Waltoft BL, Leckman JF, Mortensen PB. Maternal History of Autoimmune Disease and Later Development of Tourette Syndrome in Offspring. Journal Of The American Academy Of Child & Adolescent Psychiatry 2015, 54: 495-501.e1. PMID: 26004665, DOI: 10.1016/j.jaac.2015.03.008.Peer-Reviewed Original ResearchConceptsAdjusted incidence rate ratioIncidence rate ratiosMaternal autoimmune diseaseRisk of TSAutoimmune diseasesTourette syndromeMaternal historyNational Danish health registersNationwide prospective cohort studyDanish health registersPrior autoimmune diseaseProspective cohort studyParental psychiatric diagnosisDiagnosis of TSCohort studyHealth registersPerson yearsPrior diagnosisNeuroimmunological disordersIncidence rateTS diagnosisPsychiatric diagnosisPossible associationPoisson regressionPaternal age
2014
Cardiovascular Safety of Stimulants in Children with Attention-Deficit/Hyperactivity Disorder: A Nationwide Prospective Cohort Study
Dalsgaard S, Kvist AP, Leckman JF, Nielsen HS, Simonsen M. Cardiovascular Safety of Stimulants in Children with Attention-Deficit/Hyperactivity Disorder: A Nationwide Prospective Cohort Study. Journal Of Child And Adolescent Psychopharmacology 2014, 24: 302-310. PMID: 24956171, PMCID: PMC4137345, DOI: 10.1089/cap.2014.0020.Peer-Reviewed Original ResearchConceptsAttention-deficit/hyperactivity disorderProspective cohort studyCardiovascular eventsCohort studyDose-response relationshipStimulant treatmentCardiovascular safetyHazard ratioRisk factorsFirst nationwide cohort studyNationwide prospective cohort studyPossible dose-response relationshipUnique personal identification numberCardiovascular adverse eventsCardiovascular risk factorsHyperactivity disorderNationwide cohort studyNational health registersStimulant usersPopulation-based sampleAdverse eventsHealth registersProspective followCox regressionPotential confoundersGender and Injuries Predict Stimulant Medication Use
Dalsgaard S, Leckman JF, Nielsen HS, Simonsen M. Gender and Injuries Predict Stimulant Medication Use. Journal Of Child And Adolescent Psychopharmacology 2014, 24: 253-259. PMID: 24813570, PMCID: PMC4064734, DOI: 10.1089/cap.2013.0101.Peer-Reviewed Original ResearchMeSH KeywordsAge FactorsAttention Deficit Disorder with HyperactivityCentral Nervous System StimulantsChildChild Development Disorders, PervasiveCraniocerebral TraumaFemaleFollow-Up StudiesHumansMaleMental DisordersPractice Patterns, Physicians'Prospective StudiesSeverity of Illness IndexSex FactorsWounds and InjuriesConceptsAttention-deficit/hyperactivity disorderStimulant treatmentNumber of injuriesADHD medicationPsychiatric disordersStimulant medicationAutism spectrum disorderFirst prospective studyGroup of patientsPopulation-based studyYears of ageEarly life predictorsStimulant medication useMedication useGroup of childrenProspective studyPharmacological treatmentHead injuryNational cohortDrug prescriptionsMale genderPsychiatric diagnosisMedicationsNational registersInjury
2011
Involvement of immunologic and biochemical mechanisms in the pathogenesis of Tourette’s syndrome
Landau YE, Steinberg T, Richmand B, Leckman JF, Apter A. Involvement of immunologic and biochemical mechanisms in the pathogenesis of Tourette’s syndrome. Journal Of Neural Transmission 2011, 119: 621-626. PMID: 22139323, PMCID: PMC3936959, DOI: 10.1007/s00702-011-0739-x.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAutoimmune DiseasesBrain ChemistryChildComorbidityFemaleHumansMaleOxidative StressProspective StudiesTourette SyndromeConceptsTourette syndrome groupTourette syndromeSyndrome groupHealthy age-matched control subjectsTertiary pediatric medical centerAge-matched control subjectsIgG-4 levelsPediatric medical centerNovel therapeutic modalitiesNon-ceruloplasmin copperQuantitative immunoglobulinsImmunological markersControl subjectsHealthy childrenMedical recordsPhonic ticsMedical CenterTherapeutic modalitiesControl groupBiochemical markersSyndromeDemographic dataBiochemical indicesOxidative stressNeurodevelopmental disorders
2010
Streptococcal Upper Respiratory Tract Infections and Exacerbations of Tic and Obsessive-Compulsive Symptoms: A Prospective Longitudinal Study
Leckman JF, King RA, Gilbert DL, Coffey BJ, Singer HS, Dure LS, Grantz H, Katsovich L, Lin H, Lombroso PJ, Kawikova I, Johnson DR, Kurlan RM, Kaplan EL. Streptococcal Upper Respiratory Tract Infections and Exacerbations of Tic and Obsessive-Compulsive Symptoms: A Prospective Longitudinal Study. Journal Of The American Academy Of Child & Adolescent Psychiatry 2010, 50: 108-118.e3. PMID: 21241948, PMCID: PMC3024577, DOI: 10.1016/j.jaac.2010.10.011.Peer-Reviewed Original ResearchConceptsExacerbation of ticsGABHS infectionStreptococcal infectionSymptom exacerbationStreptococcal upper respiratory tract infectionPediatric autoimmune neuropsychiatric disordersUpper respiratory tract infectionObsessive-compulsive symptomsAutoimmune neuropsychiatric disordersHemolytic streptococcal infectionRespiratory tract infectionsThroat swab cultureLongitudinal studyProspective longitudinal studyPANDAS subjectsClinical exacerbationStreptococcal antibodiesTract infectionsClinical symptomsGABHS infectionsGroup of childrenLaboratory valuesSwab culturesClinical conditionsClinical evaluatorsOxytocin and the Development of Parenting in Humans
Gordon I, Zagoory-Sharon O, Leckman JF, Feldman R. Oxytocin and the Development of Parenting in Humans. Biological Psychiatry 2010, 68: 377-382. PMID: 20359699, PMCID: PMC3943240, DOI: 10.1016/j.biopsych.2010.02.005.Peer-Reviewed Original ResearchThe Human Immune Response to Streptococcal Extracellular Antigens: Clinical, Diagnostic, and Potential Pathogenetic Implications
Johnson DR, Kurlan R, Leckman J, Kaplan EL. The Human Immune Response to Streptococcal Extracellular Antigens: Clinical, Diagnostic, and Potential Pathogenetic Implications. Clinical Infectious Diseases 2010, 50: 481-490. PMID: 20067422, DOI: 10.1086/650167.Peer-Reviewed Original ResearchConceptsAntibody titersImmune responseSingle antibody titerStreptococcal extracellular antigensB antibody titersHuman antibody responseHuman immune responsePaediatric study participantsSymptoms of infectionPotential pathogenetic implicationsThroat culturesGAS infectionAntibody responseSubsequent sequelaePathogenetic mechanismsImmunologic confirmationBlood samplesEpidemiological studiesPathogenetic implicationsStreptococcus antigensCulture resultsStudy participantsImportant human pathogenInfectionExtracellular antigens
2009
Streptococcal Upper Respiratory Tract Infections and Psychosocial Stress Predict Future Tic and Obsessive-Compulsive Symptom Severity in Children and Adolescents with Tourette Syndrome and Obsessive-Compulsive Disorder
Lin H, Williams KA, Katsovich L, Findley DB, Grantz H, Lombroso PJ, King RA, Bessen DE, Johnson D, Kaplan EL, Landeros-Weisenberger A, Zhang H, Leckman JF. Streptococcal Upper Respiratory Tract Infections and Psychosocial Stress Predict Future Tic and Obsessive-Compulsive Symptom Severity in Children and Adolescents with Tourette Syndrome and Obsessive-Compulsive Disorder. Biological Psychiatry 2009, 67: 684-691. PMID: 19833320, PMCID: PMC2843763, DOI: 10.1016/j.biopsych.2009.08.020.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAnti-Bacterial AgentsAttention Deficit Disorder with HyperactivityChildDepressive DisorderFemaleForecastingHumansLife Change EventsMaleObsessive-Compulsive DisorderPredictive Value of TestsProspective StudiesPsychologyRespiratory Tract InfectionsSeverity of Illness IndexStreptococcal InfectionsTicsTourette SyndromeConceptsDepressive symptom severityObsessive-compulsive disorderGABHS infectionPsychosocial stressTourette syndromeSymptom severityControl subjectsStreptococcal upper respiratory tract infectionUpper respiratory tract infectionBeta-hemolytic streptococcal infectionCurrent psychosocial stressRespiratory tract infectionsHealthy control subjectsProspective longitudinal studyEarly-onset obsessive-compulsive disorderMinority of childrenOC symptom severityTract infectionsStreptococcal infectionGABHS infectionsObsessive-compulsive symptom severityClinical ratingsNew infectionsClinical ratersControl status
2006
Psychosocial stress predicts future symptom severities in children and adolescents with Tourette syndrome and/or obsessive‐compulsive disorder
Lin H, Katsovich L, Ghebremichael M, Findley DB, Grantz H, Lombroso PJ, King RA, Zhang H, Leckman JF. Psychosocial stress predicts future symptom severities in children and adolescents with Tourette syndrome and/or obsessive‐compulsive disorder. Journal Of Child Psychology And Psychiatry 2006, 48: 157-166. PMID: 17300554, PMCID: PMC3073143, DOI: 10.1111/j.1469-7610.2006.01687.x.Peer-Reviewed Original ResearchConceptsDepressive symptom severityFuture depressive symptomsHealthy control subjectsObsessive-compulsive disorderDepressive symptomsPsychosocial stressTourette syndromeSymptom severityControl subjectsLong-term contextual threatSeverity of ticsProspective longitudinal studyChronological ageIndependent predictorsOC symptomsTic severityOC symptom severityPsychosocial adversitySymptomsFuture symptom severityClinician ratingsSeverityParental reportsSignificant predictorsLongitudinal studyIdentification of pyruvate kinase as an antigen associated with Tourette syndrome
Kansy JW, Katsovich L, McIver KS, Pick J, Zabriskie JB, Lombroso PJ, Leckman JF, Bibb JA. Identification of pyruvate kinase as an antigen associated with Tourette syndrome. Journal Of Neuroimmunology 2006, 181: 165-176. PMID: 17011640, PMCID: PMC1853370, DOI: 10.1016/j.jneuroim.2006.08.007.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAmino Acid SequenceAnimalsAntibodies, BacterialAntigensAutoantibodiesBrainChildCross ReactionsHumansImmunohistochemistryLongitudinal StudiesMaleMiceMice, Inbred C57BLMolecular Sequence DataProspective StudiesPyruvate KinaseRatsSeroepidemiologic StudiesStreptococcal InfectionsTicsTourette SyndromeConceptsStreptococcal infectionObsessive-compulsive disorderTourette syndromeAutoimmune targetExacerbated symptomsBeta-hemolytic streptococcal infectionEarly-onset obsessive-compulsive disorderStreptococcal M proteinPediatric populationTic disordersImmune responseSurface antigenInfectious strainsSyndromeInfectionDisordersPyruvate kinaseM proteinPatientsImmunoreactivitySymptomsAntigenAntibodiesGlycolytic enzymesM1 isoformAdulthood Outcome of Tic and Obsessive-Compulsive Symptom Severity in Children With Tourette Syndrome
Bloch MH, Peterson BS, Scahill L, Otka J, Katsovich L, Zhang H, Leckman JF. Adulthood Outcome of Tic and Obsessive-Compulsive Symptom Severity in Children With Tourette Syndrome. JAMA Pediatrics 2006, 160: 65-69. PMID: 16389213, PMCID: PMC2291298, DOI: 10.1001/archpedi.160.1.65.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAdrenergic alpha-AgonistsAdultAntipsychotic AgentsAttention Deficit Disorder with HyperactivityBipolar DisorderChildDepressive DisorderFemaleFollow-Up StudiesHumansIntelligence TestsMaleObsessive-Compulsive DisorderProspective StudiesSchizophreniaSelective Serotonin Reuptake InhibitorsSeverity of Illness IndexTic DisordersTourette SyndromeConceptsTic symptomsTourette syndromeTic severitySymptom severityObsessive-compulsive disorderBaseline clinical measurementsChildhood-onset neuropsychiatric disorderOCD symptomsPercent of patientsProspective cohort studyPercent of subjectsOutpatient specialty clinicsThird of childrenThird of adultsAge 14 yearsStructured clinical evaluationCohort studyClinical courseComplete resolutionClinical evaluationPhonic ticsSpecialty clinicFollow-up interviewObsessive-compulsive symptom severityAverage ageDisruptive behavior problems in a community sample of children with tic disorders.
Scahill L, Williams S, Schwab-Stone M, Applegate J, Leckman JF. Disruptive behavior problems in a community sample of children with tic disorders. Advances In Neurology 2006, 99: 184-90. PMID: 16536365.Peer-Reviewed Original Research
2005
Increased serum levels of interleukin-12 and tumor necrosis factor-alpha in Tourette’s syndrome
Leckman JF, Katsovich L, Kawikova I, Lin H, Zhang H, Krönig H, Morshed S, Parveen S, Grantz H, Lombroso PJ, King RA. Increased serum levels of interleukin-12 and tumor necrosis factor-alpha in Tourette’s syndrome. Biological Psychiatry 2005, 57: 667-673. PMID: 15780855, DOI: 10.1016/j.biopsych.2004.12.004.Peer-Reviewed Original ResearchConceptsEarly-onset obsessive-compulsive disorderObsessive-compulsive disorderSymptom exacerbationInterleukin-12Control subjectsImmune responseTourette syndromeTumor necrosis factor-alpha concentrationsNecrosis factor-alpha concentrationsAge-matched control subjectsInvolvement of innateLocal cytokine synthesisT cell immunityHumoral immune responseCentral nervous systemInnate immune responseLongitudinal studyProspective longitudinal studyT cell activationCell immunitySerum levelsPediatric populationCommon infectionsSerum concentrationsInflammatory process
2003
Development of the Yale Children’s Global Stress Index (YCGSI) and Its Application in Children and Adolescents With Tourette’s Syndrome and Obsessive-Compulsive Disorder
FINDLEY DB, LECKMAN JF, KATSOVICH L, LIN H, ZHANG H, GRANTZ H, OTKA J, LOMBROSO PJ, KING RA. Development of the Yale Children’s Global Stress Index (YCGSI) and Its Application in Children and Adolescents With Tourette’s Syndrome and Obsessive-Compulsive Disorder. Journal Of The American Academy Of Child & Adolescent Psychiatry 2003, 42: 450-457. PMID: 12649632, DOI: 10.1097/01.chi.0000046816.95464.ef.Peer-Reviewed Original ResearchConceptsObsessive-compulsive disorderTourette syndromeDaily Life Stressors ScalePsychosocial stressAge-matched control subjectsClinician ratingsClinical rating instrumentGlobal clinician ratingsTime pointsGlobal Stress IndexCross-sectional ratingsEarly-onset obsessive-compulsive disorderPsychometric propertiesControl subjectsClinical severityObsessive-compulsive symptom severityStudy of childrenAcceptable psychometric propertiesStress indexSymptom severitySyndromePossible differential contributionInterrater reliabilityStressor ScaleDisorders
2002
Assessment of Symptom Exacerbations in a Longitudinal Study of Children With Tourette's Syndrome or Obsessive-Compulsive Disorder
LIN H, YEH CB, PETERSON BS, SCAHILL L, GRANTZ H, FINDLEY DB, KATSOVICH L, OTKA J, LOMBROSO PJ, KING RA, LECKMAN JF. Assessment of Symptom Exacerbations in a Longitudinal Study of Children With Tourette's Syndrome or Obsessive-Compulsive Disorder. Journal Of The American Academy Of Child & Adolescent Psychiatry 2002, 41: 1070-1077. PMID: 12218428, DOI: 10.1097/00004583-200209000-00007.Peer-Reviewed Original Research
1999
Early parental preoccupations and behaviors and their possible relationship to the symptoms of obsessive‐compulsive disorder
Leckman JF, Mayes LC, Feldman R, Evans DW, King RA, Cohen DJ. Early parental preoccupations and behaviors and their possible relationship to the symptoms of obsessive‐compulsive disorder. Acta Psychiatrica Scandinavica. Supplementum 1999, 100: 1-26. PMID: 10478283, DOI: 10.1111/j.1600-0447.1999.tb10951.x.Peer-Reviewed Original Research