2019
The impact of attention deficit hyperactivity disorder in obsessive‐compulsive disorder subjects
Blanco‐Vieira T, Santos M, Ferrão YA, Torres AR, Miguel EC, Bloch MH, Leckman JF, do Rosario MC. The impact of attention deficit hyperactivity disorder in obsessive‐compulsive disorder subjects. Depression And Anxiety 2019, 36: 533-542. PMID: 30990937, DOI: 10.1002/da.22898.Peer-Reviewed Original ResearchConceptsAttention deficit hyperactivity disorderAdult OCD patientsObsessive-compulsive disorderDeficit hyperactivity disorderOCD patientsClinical characteristicsExact testFeatures of ADHDHyperactivity disorderSubgroup of patientsAdult obsessive-compulsive disorderComorbid attention deficit hyperactivity disorderSpecific clinical featuresCross-sectional studyObsessive-compulsive disorder (OCD) subjectsLogistic regression analysisFisher's exact testBrazilian Research ConsortiumMann-Whitney testAdult patientsRheumatic feverDevelopment of interventionsClinical featuresObsessive-compulsive spectrum disordersLifetime prevalence
2013
Partitioning the Heritability of Tourette Syndrome and Obsessive Compulsive Disorder Reveals Differences in Genetic Architecture
Davis LK, Yu D, Keenan CL, Gamazon ER, Konkashbaev AI, Derks EM, Neale BM, Yang J, Lee SH, Evans P, Barr CL, Bellodi L, Benarroch F, Berrio GB, Bienvenu OJ, Bloch MH, Blom RM, Bruun RD, Budman CL, Camarena B, Campbell D, Cappi C, Silgado J, Cath DC, Cavallini MC, Chavira DA, Chouinard S, Conti DV, Cook EH, Coric V, Cullen BA, Deforce D, Delorme R, Dion Y, Edlund CK, Egberts K, Falkai P, Fernandez TV, Gallagher PJ, Garrido H, Geller D, Girard SL, Grabe HJ, Grados MA, Greenberg BD, Gross-Tsur V, Haddad S, Heiman GA, Hemmings SM, Hounie AG, Illmann C, Jankovic J, Jenike MA, Kennedy JL, King RA, Kremeyer B, Kurlan R, Lanzagorta N, Leboyer M, Leckman JF, Lennertz L, Liu C, Lochner C, Lowe TL, Macciardi F, McCracken JT, McGrath LM, Restrepo S, Moessner R, Morgan J, Muller H, Murphy DL, Naarden AL, Ochoa WC, Ophoff RA, Osiecki L, Pakstis AJ, Pato MT, Pato CN, Piacentini J, Pittenger C, Pollak Y, Rauch SL, Renner TJ, Reus VI, Richter MA, Riddle MA, Robertson MM, Romero R, Rosàrio MC, Rosenberg D, Rouleau GA, Ruhrmann S, Ruiz-Linares A, Sampaio AS, Samuels J, Sandor P, Sheppard B, Singer HS, Smit JH, Stein DJ, Strengman E, Tischfield JA, Duarte A, Vallada H, Van Nieuwerburgh F, Veenstra-VanderWeele J, Walitza S, Wang Y, Wendland JR, Westenberg HG, Shugart YY, Miguel EC, McMahon W, Wagner M, Nicolini H, Posthuma D, Hanna GL, Heutink P, Denys D, Arnold PD, Oostra BA, Nestadt G, Freimer NB, Pauls DL, Wray NR, Stewart SE, Mathews CA, Knowles JA, Cox NJ, Scharf JM. Partitioning the Heritability of Tourette Syndrome and Obsessive Compulsive Disorder Reveals Differences in Genetic Architecture. PLOS Genetics 2013, 9: e1003864. PMID: 24204291, PMCID: PMC3812053, DOI: 10.1371/journal.pgen.1003864.Peer-Reviewed Original ResearchConceptsGenome-wide complex trait analysisExpression quantitative trait lociGenetic architectureGenetic correlationsGenome-wide common variant dataQuantitative trait lociComplex trait analysisDistinct genetic architecturesGenomic architectureGenomic elementsFunctional annotationMinor allele frequencyTrait lociPrevious heritability estimatesMAF binsGWAS studiesGene expressionTrait analysisHeritabilityGenetic overlapVariant dataHeritability estimatesAllele frequenciesCommon variationSNPsGene variants associated with antisocial behaviour: a latent variable approach
Bentley MJ, Lin H, Fernandez TV, Lee M, Yrigollen CM, Pakstis AJ, Katsovich L, Olds DL, Grigorenko EL, Leckman JF. Gene variants associated with antisocial behaviour: a latent variable approach. Journal Of Child Psychology And Psychiatry 2013, 54: 1074-1085. PMID: 23822756, PMCID: PMC3766409, DOI: 10.1111/jcpp.12109.Peer-Reviewed Original ResearchConceptsRisk allelesGenetic risk allelesSingle nucleotide polymorphismsGene variantsNurse home visitation programAge 15 yearsStress response pathwaysCholinergic signalingDrug useCommon genetic variantsPutative risk allelesAntisocial behaviorVariable scoresResponse pathwaysGenetic polymorphismsVisitation programMolecular networksPathway analysisStress responseGenesGenetic variablesMolecular levelGenetic variants
2009
Autism spectrum and obsessive–compulsive disorders: OC behaviors, phenotypes and genetics
Jacob S, Landeros‐Weisenberger A, Leckman JF. Autism spectrum and obsessive–compulsive disorders: OC behaviors, phenotypes and genetics. Autism Research 2009, 2: 293-311. PMID: 20029829, PMCID: PMC3974607, DOI: 10.1002/aur.108.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsChildChild Development Disorders, PervasiveChild, PreschoolComorbidityDiagnosis, DifferentialDisease Models, AnimalDiseases in TwinsGenetic Association StudiesGenetic Predisposition to DiseaseGenotypeHumansInfantIntellectual DisabilityInterview, PsychologicalNeuropsychological TestsObsessive-Compulsive DisorderPhenotypeQuantitative Trait, HeritableStereotyped BehaviorConceptsAutism spectrum disorderObsessive-compulsive behaviorObsessive-compulsive disorderNovel treatment interventionsFamily genetic studiesAutism spectrumGeneralist genesOC behaviorSpectrum disorderRare genetic variantsASD variesHeritable endophenotypeASD phenotypeCandidate gene studiesNovel genomic technologiesNonparametric linkage analysisInnovative statistical approachChronological ageGenetic mechanismsGenomic technologiesTreatment interventionsGenetic analysisGenetic influencesLinkage analysisGene studies
2008
A Developmental and Evolutionary Perspective on Obsessive-Compulsive Disorder: Whence and Whither Compulsive Hoarding?
Leckman JF, Bloch MH. A Developmental and Evolutionary Perspective on Obsessive-Compulsive Disorder: Whence and Whither Compulsive Hoarding? American Journal Of Psychiatry 2008, 165: 1229-1233. PMID: 18829875, DOI: 10.1176/appi.ajp.2008.08060891.Peer-Reviewed Original Research
2007
Co-existence of tic disorders and attention-deficit/hyperactivity disorder-recent advances in understanding and treatment
Rothenberger A, Roessner V, Banaschewski T, Leckman JF. Co-existence of tic disorders and attention-deficit/hyperactivity disorder-recent advances in understanding and treatment. European Child & Adolescent Psychiatry 2007, 16: 1-4. PMID: 17665277, DOI: 10.1007/s00787-007-1001-9.Peer-Reviewed Original ResearchMeSH KeywordsAttention Deficit Disorder with HyperactivityChildComorbidityHumansLearningPhenotypeTic DisordersConceptsAttention-deficit/hyperactivity disorderTic disordersTreatment of youthHyperactivity disorderCognitive disturbancesFuture researchOwn clinical entityDaily clinical practiceEvidence-based approachClinical entityDisordersTreatment choiceClinical practiceDifferential diagnosticsEssential research topicEndophenotypesYouthDifferent levelsTreatmentUnderstandingBetter understandingResearch topic
2006
Principal Components Analysis of Obsessive–Compulsive Disorder Symptoms in Children and Adolescents
Stewart SE, Rosario MC, Brown TA, Carter AS, Leckman JF, Sukhodolsky D, Katsovitch L, King R, Geller D, Pauls DL. Principal Components Analysis of Obsessive–Compulsive Disorder Symptoms in Children and Adolescents. Biological Psychiatry 2006, 61: 285-291. PMID: 17161383, DOI: 10.1016/j.biopsych.2006.08.040.Peer-Reviewed Original ResearchA Controlled Family Study of Attention-Deficit/Hyperactivity Disorder and Tourette's Disorder
STEWART SE, ILLMANN C, GELLER DA, LECKMAN JF, KING R, PAULS DL. A Controlled Family Study of Attention-Deficit/Hyperactivity Disorder and Tourette's Disorder. Journal Of The American Academy Of Child & Adolescent Psychiatry 2006, 45: 1354-1362. PMID: 17075358, DOI: 10.1097/01.chi.0000251211.36868.fe.Peer-Reviewed Original ResearchA Primary Candidate Gene for Obsessive-compulsive Disorder
Leckman JF, Kim YS. A Primary Candidate Gene for Obsessive-compulsive Disorder. JAMA Psychiatry 2006, 63: 717-720. PMID: 16818860, DOI: 10.1001/archpsyc.63.7.717.Peer-Reviewed Original Research
2005
A Multidimensional Model of Obsessive-Compulsive Disorder
Mataix-Cols D, Rosario-Campos MC, Leckman JF. A Multidimensional Model of Obsessive-Compulsive Disorder. American Journal Of Psychiatry 2005, 162: 228-238. PMID: 15677583, DOI: 10.1176/appi.ajp.162.2.228.Peer-Reviewed Original ResearchBrainCognitive Behavioral TherapyDiagnostic ImagingFactor Analysis, StatisticalGenetic Predisposition to DiseaseHumansModels, NeurologicalModels, PsychologicalNeuropsychological TestsObsessive-Compulsive DisorderPersonality InventoryPhenotypePredictive Value of TestsPrincipal Component AnalysisPsychiatric Status Rating ScalesReproducibility of ResultsSelective Serotonin Reuptake Inhibitors
2004
Obsessive-compulsive disorder phenotypes: implications for genetic studies
Miguel EC, Leckman JF, Rauch S, do Rosario-Campos MC, Hounie AG, Mercadante MT, Chacon P, Pauls DL. Obsessive-compulsive disorder phenotypes: implications for genetic studies. Molecular Psychiatry 2004, 10: 258-275. PMID: 15611786, DOI: 10.1038/sj.mp.4001617.Peer-Reviewed Original ResearchObsessive‐compulsive symptoms in parents of Tourette syndrome probands and autism spectrum disorder probands
KANO Y, OHTA M, NAGAI Y, PAULS DL, LECKMAN JF. Obsessive‐compulsive symptoms in parents of Tourette syndrome probands and autism spectrum disorder probands. Psychiatry And Clinical Neurosciences 2004, 58: 348-352. PMID: 15298645, DOI: 10.1111/j.1440-1819.2004.01266.x.Peer-Reviewed Original Research
2003
Epigenetic abnormalities associated with a chromosome 18(q21-q22) inversion and a Gilles de la Tourette syndrome phenotype
State MW, Greally JM, Cuker A, Bowers PN, Henegariu O, Morgan TM, Gunel M, DiLuna M, King RA, Nelson C, Donovan A, Anderson GM, Leckman JF, Hawkins T, Pauls DL, Lifton RP, Ward DC. Epigenetic abnormalities associated with a chromosome 18(q21-q22) inversion and a Gilles de la Tourette syndrome phenotype. Proceedings Of The National Academy Of Sciences Of The United States Of America 2003, 100: 4684-4689. PMID: 12682296, PMCID: PMC153616, DOI: 10.1073/pnas.0730775100.Peer-Reviewed Original ResearchObsessions and compulsions in anorexia nervosa subtypes
Halmi KA, Sunday SR, Klump KL, Strober M, Leckman JF, Fichter M, Kaplan A, Woodside B, Treasure J, Berrettini WH, Al Shabboat M, Bulik CM, Kaye WH. Obsessions and compulsions in anorexia nervosa subtypes. International Journal Of Eating Disorders 2003, 33: 308-319. PMID: 12655628, DOI: 10.1002/eat.10138.Peer-Reviewed Original Research
2002
Obsessive‐compulsive symptom dimensions in affected sibling pairs diagnosed with Gilles de la Tourette syndrome
Leckman JF, Pauls DL, Zhang H, Rosario‐Campos M, Katsovich L, Kidd KK, Pakstis AJ, Alsobrook JP, Robertson MM, McMahon WM, Walkup JT, van de Wetering BJ, King RA, Cohen DJ. Obsessive‐compulsive symptom dimensions in affected sibling pairs diagnosed with Gilles de la Tourette syndrome. American Journal Of Medical Genetics Part B Neuropsychiatric Genetics 2002, 116B: 60-68. PMID: 12497616, DOI: 10.1002/ajmg.b.10001.Peer-Reviewed Original ResearchGenomewide Scan of Hoarding in Sib Pairs in Which Both Sibs Have Gilles de la Tourette Syndrome
Zhang H, Leckman JF, Pauls DL, Tsai CP, Kidd KK, Campos MR, Genetics T. Genomewide Scan of Hoarding in Sib Pairs in Which Both Sibs Have Gilles de la Tourette Syndrome. American Journal Of Human Genetics 2002, 70: 896-904. PMID: 11840360, PMCID: PMC379118, DOI: 10.1086/339520.Peer-Reviewed Original ResearchAllelesBehavioral SymptomsChromosomes, HumanChromosomes, Human, Pair 17Chromosomes, Human, Pair 4Chromosomes, Human, Pair 5Gene FrequencyGenetic LinkageGenetic MarkersGenome, HumanHumansMatched-Pair AnalysisNuclear FamilyObsessive-Compulsive DisorderPhenotypeQuantitative Trait, HeritableSoftwareStatistics, NonparametricTourette SyndromeMaternal behavior and developmental psychopathology
Leckman JF, Herman AE. Maternal behavior and developmental psychopathology. Biological Psychiatry 2002, 51: 27-43. PMID: 11801229, DOI: 10.1016/s0006-3223(01)01277-x.Peer-Reviewed Original ResearchConceptsMaternal behaviorNeuronal nitric oxide synthaseEstrogen alpha receptorsNitric oxide synthaseMouse strain backgroundDopamine beta hydroxylaseGene knockout dataAnimal model systemsGene knockout studiesGene knockout technologyPeer-reviewed journalsOxide synthaseAlpha receptorsBehavioral deficitsSearch of literatureBeta hydroxylaseDisease pathogenesisTranscription factorsMolecular basisGenetic factorsKnockout studiesSpecific genesKnockout dataKnockout technologyStrain background
1995
Basic Fibroblast Growth Factor Increases the Number of Excitatory Neurons Containing Glutamate in the Cerebral Cortex
Vaccarino F, Schwartz M, Hartigan D, Leckman J. Basic Fibroblast Growth Factor Increases the Number of Excitatory Neurons Containing Glutamate in the Cerebral Cortex. Cerebral Cortex 1995, 5: 64-78. PMID: 7719131, DOI: 10.1093/cercor/5.1.64.Peer-Reviewed Original ResearchConceptsBasic fibroblast growth factorNerve growth factorGlutamate-containing neuronsCerebral cortexFibroblast growth factorGrowth factorAspartate-containing neuronsDifferent neurotransmitter phenotypesNumber of GABARatio of glutamateStem cellsNeurotransmitter phenotypeExcitatory neuronsInhibitory neuronsRat telencephalonVentricular zoneBFGF mRNAGABANeuronsCortexGlutamateDiffusible factorsThreefold increaseCellsFactors
1992
Pathogenesis of Tourette syndrome. Clues from the clinical phenotype and natural history.
Leckman JF, Pauls DL, Peterson BS, Riddle MA, Anderson GM, Cohen DJ. Pathogenesis of Tourette syndrome. Clues from the clinical phenotype and natural history. Advances In Neurology 1992, 58: 15-24. PMID: 1414618.Peer-Reviewed Original Research