2017
Temporal Association of Certain Neuropsychiatric Disorders Following Vaccination of Children and Adolescents: A Pilot Case–Control Study
Leslie DL, Kobre RA, Richmand BJ, Guloksuz S, Leckman JF. Temporal Association of Certain Neuropsychiatric Disorders Following Vaccination of Children and Adolescents: A Pilot Case–Control Study. Frontiers In Psychiatry 2017, 8: 3. PMID: 28154539, PMCID: PMC5244035, DOI: 10.3389/fpsyt.2017.00003.Peer-Reviewed Original ResearchObsessive-compulsive disorderAnorexia nervosaNeuropsychiatric disordersPrior vaccinationPilot case-control studyAnxiety disordersConditional logistic regression modelsClear public health benefitsVaccination of childrenCase-control studyChronic tic disorderMajor depressive disorderChildhood infectious diseasesCertain neuropsychiatric disordersAttention deficit hyperactivity disorderPublic health benefitsLogistic regression modelsAntecedent administrationAntecedent infectionAntecedent vaccinationDeficit hyperactivity disorderInfluenza vaccinationVaccination scheduleIncident diagnosisCDC guidelines
2015
Obsessive–compulsive symptoms are associated with psychiatric comorbidities, behavioral and clinical problems: a population-based study of Brazilian school children
Alvarenga PG, do Rosario MC, Cesar RC, Manfro GG, Moriyama TS, Bloch MH, Shavitt RG, Hoexter MQ, Coughlin CG, Leckman JF, Miguel EC. Obsessive–compulsive symptoms are associated with psychiatric comorbidities, behavioral and clinical problems: a population-based study of Brazilian school children. European Child & Adolescent Psychiatry 2015, 25: 175-182. PMID: 26015374, DOI: 10.1007/s00787-015-0723-3.Peer-Reviewed Original ResearchConceptsFamily History ScreenObsessive-compulsive disorderObsessive-compulsive symptomsSchool-aged childrenChild Behavior ChecklistUnaffected controlsPediatric-onset obsessive-compulsive disorderPresence of OCSPopulation-based studyComorbid psychiatric disordersMajor depressive disorderWell-Being AssessmentOCD groupBrazilian school childrenGroup of childrenPsychiatric comorbidityDepressive disorderClinical impactFunctional impairmentPsychiatric disordersClinical problemOCS groupDiagnostic groupsSignificant socio-demographic differencesSocio-demographic differences
2009
Meta-analysis of the dose-response relationship of SSRI in obsessive-compulsive disorder
Bloch MH, McGuire J, Landeros-Weisenberger A, Leckman JF, Pittenger C. Meta-analysis of the dose-response relationship of SSRI in obsessive-compulsive disorder. Molecular Psychiatry 2009, 15: 850-855. PMID: 19468281, PMCID: PMC2888928, DOI: 10.1038/mp.2009.50.Peer-Reviewed Original ResearchConceptsSelective serotonin reuptake inhibitorsY-BOCS scoresSerotonin reuptake inhibitorsObsessive-compulsive disorderHigh dosesReuptake inhibitorsTreatment respondersDose of SSRIsTreatment efficacyDouble-blind placebo-controlled clinical trialGreater side effect burdenPlacebo-controlled clinical trialSide effect burdenAbsolute risk differenceTreatment of adultsGreater treatment efficacyMajor depressive disorderImproved treatment efficacyTreatment of OCDDose-response relationshipRevMan 4.2.8Clinical trialsDepressive disorderCause dropoutsMean change
2008
Neuropsychiatric Disorders Associated With Streptococcal Infection: A Case-Control Study Among Privately Insured Children
Leslie DL, Kozma L, Martin A, Landeros A, Katsovich L, King RA, Leckman JF. Neuropsychiatric Disorders Associated With Streptococcal Infection: A Case-Control Study Among Privately Insured Children. Journal Of The American Academy Of Child & Adolescent Psychiatry 2008, 47: 1166-1172. PMID: 18724258, PMCID: PMC2783578, DOI: 10.1097/chi.0b013e3181825a3d.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAttention Deficit Disorder with HyperactivityCase-Control StudiesChildChild, PreschoolCross-Sectional StudiesDepressive Disorder, MajorFemaleHealth SurveysHumansIncidenceInsurance, HealthMaleMigraine DisordersNeurocognitive DisordersObsessive-Compulsive DisorderOdds RatioOtitis MediaRiskSinusitisStreptococcal InfectionsTic DisordersTourette SyndromeUnited StatesConceptsMajor depressive disorderAttention-deficit/hyperactivity disorderPrior streptococcal infectionStreptococcal infectionObsessive-compulsive disorderTic disordersTourette syndromeNeuropsychiatric disordersConditional logistic regression modelsStreptococcal sore throatDiagnosis of OCDCase-control studyLogistic regression modelsSore throatIncident diagnosisEpidemiologic evidenceDepressive disorderSubsequent diagnosisNoninfectious conditionsScarlet feverChildren ages 4Immune systemInfectious diseasesInfectionDiagnosis
2007
Parental representations and subclinical changes in postpartum mood
Mayes LC, Leckman JF. Parental representations and subclinical changes in postpartum mood. Infant Mental Health Journal 2007, 28: 281-295. PMID: 28640466, DOI: 10.1002/imhj.20136.Peer-Reviewed Original ResearchPeripartum periodMonths postpartumEarly parenting experiencesPast historyImmediate postpartum periodMajor depressive disorderMood fluctuationsSocial supportParents' perceptionsSubclinical changesPostpartum periodMore episodesDepressive disorderMajor depressionPostpartum depressionPostpartum moodMonths gestationDepressed moodMaternal careParenting experiencesMothersNew infantParental moodDepressionPostpartum
2000
The Psychiatric Symptoms of Rheumatic Fever
Mercadante MT, Busatto GF, Lombroso PJ, Prado L, Rosário-Campos MC, do Valle R, Marques-Dias MJ, Kiss MH, Leckman JF, Miguel EC. The Psychiatric Symptoms of Rheumatic Fever. American Journal Of Psychiatry 2000, 157: 2036-2038. PMID: 11097972, DOI: 10.1176/appi.ajp.157.12.2036.Peer-Reviewed Original ResearchConceptsAttention deficit hyperactivity disorderRheumatic feverSydenham's choreaTic disordersHigh riskComparison groupFever groupMajor depressive disorderDeficit hyperactivity disorderObsessive-compulsive disorderDepressive disorderRisk factorsPsychiatric symptomsPsychiatric disordersChoreaFeverNeuropsychiatric disordersObsessive-compulsive symptomsRating ScaleHyperactivity disorderSymptomsDisordersADHD symptomsChildrenSemistructured interviews