2024
The trajectory of anxiety symptoms during the transition from childhood to young adulthood is predicted by IQ and sex, but not polygenic risk scores
Salto A, Salum G, Hoffmann M, Santoro M, Zugman A, Pan P, Belangero S, Ito L, Doretto V, Croci M, Brañas M, de Giusti C, Da Silva‐Jr F, Ribeiro S, Miguel E, Leckman J. The trajectory of anxiety symptoms during the transition from childhood to young adulthood is predicted by IQ and sex, but not polygenic risk scores. JCPP Advances 2024 DOI: 10.1002/jcv2.12268.Peer-Reviewed Original ResearchAnxiety symptomsIntelligence quotientTrajectory class membershipPolygenic risk scoresTrajectory classesLate adolescenceCourse of anxiety symptomsScreen for Child Anxiety Related DisordersTrajectories of anxiety symptomsBrazilian High-Risk CohortYoung adulthoodEffect of intelligence quotientAnxiety related disordersHigh-decreasing classClass membershipLongitudinal studyConfirmatory factor analysisGrowth mixture modelingIncidence of anxiety symptomsInternalizing symptomatologyLow-increasing classHigher IQCognitive abilitiesAnxiety riskFactor analysis
2018
DNA methylome variation in a perinatal nurse-visitation program that reduces child maltreatment: a 27-year follow-up
O’Donnell K, Chen L, MacIsaac JL, McEwen LM, Nguyen T, Beckmann K, Zhu Y, Chen LM, Brooks-Gunn J, Goldman D, Grigorenko EL, Leckman JF, Diorio J, Karnani N, Olds DL, Holbrook JD, Kobor MS, Meaney MJ. DNA methylome variation in a perinatal nurse-visitation program that reduces child maltreatment: a 27-year follow-up. Translational Psychiatry 2018, 8: 15. PMID: 29317599, PMCID: PMC5802588, DOI: 10.1038/s41398-017-0063-9.Peer-Reviewed Original ResearchConceptsNurse-Family PartnershipIntervention programsProspective longitudinal studyYears of ageMajor psychiatric disordersAge 27 yearsChild maltreatmentPsychosocial intervention programEarly intervention programsLifestyle factorsIntervention groupBlood samplesPsychiatric disordersAdult offspringDiagnostic InterviewChildhood adversityNFP programInterindividual variationLongitudinal studyComponent scoresSustained impactAbuse/neglectDNA methylationFamily partnershipsDNA methylome
2015
A Prospective Longitudinal Study of Perceived Infant Outcomes at 18–24 Months: Neural and Psychological Correlates of Parental Thoughts and Actions Assessed during the First Month Postpartum
Kim P, Rigo P, Leckman JF, Mayes LC, Cole PM, Feldman R, Swain JE. A Prospective Longitudinal Study of Perceived Infant Outcomes at 18–24 Months: Neural and Psychological Correlates of Parental Thoughts and Actions Assessed during the First Month Postpartum. Frontiers In Psychology 2015, 6: 1772. PMID: 26635679, PMCID: PMC4654106, DOI: 10.3389/fpsyg.2015.01772.Peer-Reviewed Original ResearchOwn infant cryThoughts/actionsSocioemotional outcomesNeural responsesParental thoughtsSocioemotional competenciesPositive thoughtsInfant cryingCurrent longitudinal studyLongitudinal studyParent-focused interventionsThoughts/behaviorsFirst month postpartumInfant-related stimuliNeuroimaging sessionAnxious thoughtsPsychological correlatesParental sensitivityProspective longitudinal studyNeural activationParent differencesMonths postpartumEmotional bondAuditory cortexInfant outcomes
2014
Neural plasticity in fathers of human infants
Kim P, Rigo P, Mayes LC, Feldman R, Leckman JF, Swain JE. Neural plasticity in fathers of human infants. Social Neuroscience 2014, 9: 522-535. PMID: 24958358, PMCID: PMC4144350, DOI: 10.1080/17470919.2014.933713.Peer-Reviewed Original ResearchConceptsFathers' brainsNeural plasticityLateral prefrontal cortexCurrent longitudinal studyPosterior cingulate cortexVoxel-based morphometry analysisGray matter volumeNeural basisCognitive developmentNeural regionsNeural changesOrbitofrontal cortexPrefrontal cortexWeeks postpartumHuman fathersParental motivationCingulate cortexHuman infantsMood symptomsBrain regionsLongitudinal studyPostpartum mood symptomsMatter volumeMorphometry analysisHuman mothers
2013
Developmental approaches to child psychopathology: longitudinal studies and implications for clinical practice.
Séguin JR, Leckman JF. Developmental approaches to child psychopathology: longitudinal studies and implications for clinical practice. Journal De L'Académie Canadienne De Psychiatrie De L'enfant Et De L'adolescent 2013, 22: 3-5. PMID: 23390426, PMCID: PMC3565708.Peer-Reviewed Original Research
2010
Streptococcal Upper Respiratory Tract Infections and Exacerbations of Tic and Obsessive-Compulsive Symptoms: A Prospective Longitudinal Study
Leckman JF, King RA, Gilbert DL, Coffey BJ, Singer HS, Dure LS, Grantz H, Katsovich L, Lin H, Lombroso PJ, Kawikova I, Johnson DR, Kurlan RM, Kaplan EL. Streptococcal Upper Respiratory Tract Infections and Exacerbations of Tic and Obsessive-Compulsive Symptoms: A Prospective Longitudinal Study. Journal Of The American Academy Of Child & Adolescent Psychiatry 2010, 50: 108-118.e3. PMID: 21241948, PMCID: PMC3024577, DOI: 10.1016/j.jaac.2010.10.011.Peer-Reviewed Original ResearchConceptsExacerbation of ticsGABHS infectionStreptococcal infectionSymptom exacerbationStreptococcal upper respiratory tract infectionPediatric autoimmune neuropsychiatric disordersUpper respiratory tract infectionObsessive-compulsive symptomsAutoimmune neuropsychiatric disordersHemolytic streptococcal infectionRespiratory tract infectionsThroat swab cultureLongitudinal studyProspective longitudinal studyPANDAS subjectsClinical exacerbationStreptococcal antibodiesTract infectionsClinical symptomsGABHS infectionsGroup of childrenLaboratory valuesSwab culturesClinical conditionsClinical evaluators
2007
Tourette Syndrome and Tic Disorders: A Decade of Progress
SWAIN JE, SCAHILL L, LOMBROSO PJ, KING RA, LECKMAN JF. Tourette Syndrome and Tic Disorders: A Decade of Progress. Journal Of The American Academy Of Child & Adolescent Psychiatry 2007, 46: 947-968. PMID: 17667475, DOI: 10.1097/chi.0b013e318068fbcc.Peer-Reviewed Original Research
2006
Psychosocial stress predicts future symptom severities in children and adolescents with Tourette syndrome and/or obsessive‐compulsive disorder
Lin H, Katsovich L, Ghebremichael M, Findley DB, Grantz H, Lombroso PJ, King RA, Zhang H, Leckman JF. Psychosocial stress predicts future symptom severities in children and adolescents with Tourette syndrome and/or obsessive‐compulsive disorder. Journal Of Child Psychology And Psychiatry 2006, 48: 157-166. PMID: 17300554, PMCID: PMC3073143, DOI: 10.1111/j.1469-7610.2006.01687.x.Peer-Reviewed Original ResearchConceptsDepressive symptom severityFuture depressive symptomsHealthy control subjectsObsessive-compulsive disorderDepressive symptomsPsychosocial stressTourette syndromeSymptom severityControl subjectsLong-term contextual threatSeverity of ticsProspective longitudinal studyChronological ageIndependent predictorsOC symptomsTic severityOC symptom severityPsychosocial adversitySymptomsFuture symptom severityClinician ratingsSeverityParental reportsSignificant predictorsLongitudinal study
2005
Increased serum levels of interleukin-12 and tumor necrosis factor-alpha in Tourette’s syndrome
Leckman JF, Katsovich L, Kawikova I, Lin H, Zhang H, Krönig H, Morshed S, Parveen S, Grantz H, Lombroso PJ, King RA. Increased serum levels of interleukin-12 and tumor necrosis factor-alpha in Tourette’s syndrome. Biological Psychiatry 2005, 57: 667-673. PMID: 15780855, DOI: 10.1016/j.biopsych.2004.12.004.Peer-Reviewed Original ResearchConceptsEarly-onset obsessive-compulsive disorderObsessive-compulsive disorderSymptom exacerbationInterleukin-12Control subjectsImmune responseTourette syndromeTumor necrosis factor-alpha concentrationsNecrosis factor-alpha concentrationsAge-matched control subjectsInvolvement of innateLocal cytokine synthesisT cell immunityHumoral immune responseCentral nervous systemInnate immune responseLongitudinal studyProspective longitudinal studyT cell activationCell immunitySerum levelsPediatric populationCommon infectionsSerum concentrationsInflammatory process
2002
Characteristics of acute stress symptoms and nitric oxide concentration in young rescue workers in Taiwan
Yeh CB, Leckman J, Wan FJ, Shiah IS, Lu RB. Characteristics of acute stress symptoms and nitric oxide concentration in young rescue workers in Taiwan. Psychiatry Research 2002, 112: 59-68. PMID: 12379451, DOI: 10.1016/s0165-1781(02)00179-8.Peer-Reviewed Original ResearchConceptsAcute stress disorderYoung military personnelControl groupMale military personnelNitric oxideInitial evaluationMilitary personnelPoint prevalence ratesAcute stress symptomsDSM-IV criteriaSignificant inverse correlationStress symptomsNitric oxide concentrationPlasma concentrationsPlasma measuresPrevalence ratesRelated syndromesNeuropsychological interviewStress disorderInverse correlationPlasma samplesLongitudinal studyPotential roleRescue workersDisaster workers