Clinical Management of Pediatric Acute-Onset Neuropsychiatric Syndrome: Part II—Use of Immunomodulatory Therapies
Frankovich J, Swedo S, Murphy T, Dale R, Agalliu D, Williams K, Daines M, Hornig M, Chugani H, Sanger T, Muscal E, Pasternack M, Cooperstock M, Gans H, Zhang Y, Cunningham M, Bernstein G, Bromberg R, Willett T, Brown K, Farhadian B, Chang K, Geller D, Hernandez J, Sherr J, Shaw R, Latimer E, Leckman J, Thienemann M, Consortium P. Clinical Management of Pediatric Acute-Onset Neuropsychiatric Syndrome: Part II—Use of Immunomodulatory Therapies. Journal Of Child And Adolescent Psychopharmacology 2017, 27: 574-593. PMID: 36358107, PMCID: PMC9836706, DOI: 10.1089/cap.2016.0148.Peer-Reviewed Original ResearchPediatric acute-onset neuropsychiatric syndromeImmunomodulatory therapyIntravenous immunoglobulinIntravenous corticosteroidsNeuropsychiatric syndromeHigh-dose intravenous corticosteroidsNonsteroidal anti-inflammatory drugsOral corticosteroid burstsPreliminary treatment guidelinesTincture of timeHigh-dose corticosteroidsFirst-line therapyTherapeutic plasma exchangeInfectious disease expertsLife-threatening severityAnti-inflammatory drugsLife-threatening impairmentComprehensive treatment protocolCognitive behavioral therapyChronic presentationCorticosteroid burstsCorticosteroid coursesPANDAS subgroupImmune abnormalitiesPAN patients