2023
Cognitive training for children with ADHD: composite cognitive score outcome in a randomized controlled trial
Bikic A, Dalsgaard S, Pittman B, Leckman J, Wexler B. Cognitive training for children with ADHD: composite cognitive score outcome in a randomized controlled trial. Nordic Journal Of Psychiatry 2023, 78: 87-91. PMID: 37905332, DOI: 10.1080/08039488.2023.2270954.Peer-Reviewed Original ResearchConceptsAttention-deficit/hyperactivity disorderCognitive trainingDeficit/hyperactivity disorderComposite cognition scoreSessions of trainingCognitive functioningHyperactivity disorderCognitive improvementCognition scoresTraining sessionsMixed resultsFrequency of trainingTrainingChildrenSessionsIntervention groupCognitionInterventionFunctioningPost Hoc AnalysisScore outcomesControl groupPrevious studiesDisordersOutcomes
2020
An examination of the relationship between regulatory T cells and symptom flare-ups in children and adolescents diagnosed with chronic tic disorder and Tourette syndrome
Yildirim Z, Karabekiroglu K, Yildiran A, Celiksoy MH, Artukoglu B, Baykal S, Babadağı Z, Leckman J. An examination of the relationship between regulatory T cells and symptom flare-ups in children and adolescents diagnosed with chronic tic disorder and Tourette syndrome. Nordic Journal Of Psychiatry 2020, 75: 18-24. PMID: 32580599, DOI: 10.1080/08039488.2020.1779808.Peer-Reviewed Original ResearchConceptsTS/chronic tic disorderChronic tic disorderSex-matched healthy controlsModerate-severe groupHealthy controlsLymphocyte countTourette syndromeLymphocyte percentagePatient groupTic disordersHC groupControl groupT-helper lymphocyte countYale Global Tic Severity ScaleT helper (TH) (CD4) numberT-lymphocyte countsT lymphocyte numbersT-lymphocyte percentageRegulatory T cellsT cell valuesTic Severity ScaleTreg percentageChildhood-onset neurodevelopmental disorderLymphocyte numbersPhonic ticsEffects of the Mother-Child Education Program on Parenting Stress and Disciplinary Practices Among Refugee and Other Marginalized Communities in Lebanon: A Pilot Randomized Controlled Trial
Ponguta LA, Issa G, Aoudeh L, Maalouf C, Hein SD, Zonderman AL, Katsovich L, Khoshnood K, Bick J, Awar A, Nourallah S, Householder S, Moore CC, Salah R, Britto PR, Leckman JF. Effects of the Mother-Child Education Program on Parenting Stress and Disciplinary Practices Among Refugee and Other Marginalized Communities in Lebanon: A Pilot Randomized Controlled Trial. Journal Of The American Academy Of Child & Adolescent Psychiatry 2020, 59: 727-738. PMID: 32014538, DOI: 10.1016/j.jaac.2019.12.010.Peer-Reviewed Original ResearchConceptsMother-Child Education ProgramIntervention groupWait-list control groupGroup-based interventionPost-intervention dataStress Index-Short FormModified intentionParenting Stress Index-Short FormIndex-Short FormUnderpowered analysesControl groupMother-child dyadsProgram attendanceEducation programsPilot studyEarly childhoodOutcomesTrialsHumanitarian settingsInterventionMultiple imputationMothersParenting stressChildrenChild outcomes
2018
Attention and executive functions computer training for attention-deficit/hyperactivity disorder (ADHD): results from a randomized, controlled trial
Bikic A, Leckman JF, Christensen TØ, Bilenberg N, Dalsgaard S. Attention and executive functions computer training for attention-deficit/hyperactivity disorder (ADHD): results from a randomized, controlled trial. European Child & Adolescent Psychiatry 2018, 27: 1563-1574. PMID: 29644473, DOI: 10.1007/s00787-018-1151-y.Peer-Reviewed Original ResearchConceptsAttention-deficit/hyperactivity disorderCognitive functionMultiple cognitive functionsComputer training programCognitive trainingHyperactivity disorderComputer trainingTraining programOutcome measuresFunctional outcome measuresIntervention groupTrainingChildrenAttentionMeasuresSecondary outcome measuresDate of registrationControl groupSignificant beneficial effectDisordersInterventionSingle-blind trialSignificant effectOutcomesTrials
2015
Cognitive computer training in children with attention deficit hyperactivity disorder (ADHD) versus no intervention: study protocol for a randomized controlled trial
Bikic A, Leckman JF, Lindschou J, Christensen TØ, Dalsgaard S. Cognitive computer training in children with attention deficit hyperactivity disorder (ADHD) versus no intervention: study protocol for a randomized controlled trial. Trials 2015, 16: 480. PMID: 26499057, PMCID: PMC4619562, DOI: 10.1186/s13063-015-0975-8.Peer-Reviewed Original ResearchConceptsAttention deficit hyperactivity disorderDeficit hyperactivity disorderCognitive functionCognitive trainingCognitive dysfunctionHyperactivity disorderComputer trainingSymptoms of inattentionMultiple cognitive functionsCommon neurodevelopmental disorderBackgroundAttention deficit hyperactivity disorderEveryday lifeCognitive skillsADHD symptomsNeurodevelopmental disordersYoung childrenWeeks of trainingPharmacological treatmentTrainingChildrenClinical superiority trialPoor generalizationLong-term effectsControl groupIntervention group
2011
Involvement of immunologic and biochemical mechanisms in the pathogenesis of Tourette’s syndrome
Landau YE, Steinberg T, Richmand B, Leckman JF, Apter A. Involvement of immunologic and biochemical mechanisms in the pathogenesis of Tourette’s syndrome. Journal Of Neural Transmission 2011, 119: 621-626. PMID: 22139323, PMCID: PMC3936959, DOI: 10.1007/s00702-011-0739-x.Peer-Reviewed Original ResearchConceptsTourette syndrome groupTourette syndromeSyndrome groupHealthy age-matched control subjectsTertiary pediatric medical centerAge-matched control subjectsIgG-4 levelsPediatric medical centerNovel therapeutic modalitiesNon-ceruloplasmin copperQuantitative immunoglobulinsImmunological markersControl subjectsHealthy childrenMedical recordsPhonic ticsMedical CenterTherapeutic modalitiesControl groupBiochemical markersSyndromeDemographic dataBiochemical indicesOxidative stressNeurodevelopmental disorders
2009
Randomized Trial of Anger Control Training for Adolescents With Tourette's Syndrome and Disruptive Behavior
Sukhodolsky DG, Vitulano LA, Carroll DH, McGuire J, Leckman JF, Scahill L. Randomized Trial of Anger Control Training for Adolescents With Tourette's Syndrome and Disruptive Behavior. Journal Of The American Academy Of Child & Adolescent Psychiatry 2009, 48: 413-421. PMID: 19242384, DOI: 10.1097/chi.0b013e3181985050.Peer-Reviewed Original ResearchConceptsClinical Global Impressions-Improvement scaleTourette syndromeACT groupControl trainingTAU control groupPrimary outcome measureIndependent evaluatorsAnger control trainingRating Scale scoresDisruptive behaviorEnd point evaluationLarge trialsBehavior rating scale scoresRandomized subjectsTAU conditionOutcome measuresScale scoreControl groupSyndromeRating ScaleACT conditionBehavior Rating ScaleAdolescentsTrialsDisruptive Behavior Rating Scale
2005
Antineural antibody in patients with Tourette’s syndrome and their family members
Yeh CB, Wu CH, Tsung HC, Chen CW, Shyu JF, Leckman JF. Antineural antibody in patients with Tourette’s syndrome and their family members. Journal Of Biomedical Science 2005, 13: 101-112. PMID: 16215701, DOI: 10.1007/s11373-005-9033-y.Peer-Reviewed Original ResearchConceptsAntineural antibodiesTourette syndromeTS patientsTic disordersControl groupFirst-degree family membersAge-matched control groupFamily membersSera of controlsImmunological pathophysiologyStreptococcal infectionPrimary cell culturesPatientsInfectious agentsSyndromeNeuropsychiatric disordersWestern blottingAntibodiesRat tissuesInteraction of geneticsGenetic vulnerabilitySerumDisordersFuture studiesCell cultures
2002
Characteristics of acute stress symptoms and nitric oxide concentration in young rescue workers in Taiwan
Yeh CB, Leckman J, Wan FJ, Shiah IS, Lu RB. Characteristics of acute stress symptoms and nitric oxide concentration in young rescue workers in Taiwan. Psychiatry Research 2002, 112: 59-68. PMID: 12379451, DOI: 10.1016/s0165-1781(02)00179-8.Peer-Reviewed Original ResearchConceptsAcute stress disorderYoung military personnelControl groupMale military personnelNitric oxideInitial evaluationMilitary personnelPoint prevalence ratesAcute stress symptomsDSM-IV criteriaSignificant inverse correlationStress symptomsNitric oxide concentrationPlasma concentrationsPlasma measuresPrevalence ratesRelated syndromesNeuropsychological interviewStress disorderInverse correlationPlasma samplesLongitudinal studyPotential roleRescue workersDisaster workers
1990
Thyroid function in fragile-X syndrome males.
Bregman JD, Leckman JF, Ort SI. Thyroid function in fragile-X syndrome males. The Yale Journal Of Biology And Medicine 1990, 63: 293-9. PMID: 2125773, PMCID: PMC2589194.Peer-Reviewed Original Research
1985
Computed tomographic brain scanning in four neuropsychiatric disorders of childhood
Harcherik DF, Cohen DJ, Ort S, Paul R, Shaywitz BA, Volkmar FR, Rothman SL, Leckman JF. Computed tomographic brain scanning in four neuropsychiatric disorders of childhood. American Journal Of Psychiatry 1985, 142: 731-734. PMID: 3859227, DOI: 10.1176/ajp.142.6.731.Peer-Reviewed Original ResearchConceptsBrain densityVentricular volumeNeuropsychiatric disordersMedical control patientsTomographic brain scanningVentricle-brain ratioTotal ventricular volumeVentricular volume ratioControl patientsMedical patientsVentricular asymmetryBrain scanningControl groupCAT scanPatientsDiagnostic groupsPatient diagnosisNeuropsychiatric patientsSignificant differencesDiagnosisDisordersChildhoodGroup