2017
Mortality risk in a nationwide cohort of individuals with tic disorders and with tourette syndrome
Meier SM, Dalsgaard S, Mortensen PB, Leckman JF, Plessen KJ. Mortality risk in a nationwide cohort of individuals with tic disorders and with tourette syndrome. Movement Disorders 2017, 32: 605-609. PMID: 28339122, DOI: 10.1002/mds.26939.Peer-Reviewed Original ResearchConceptsTic disordersTourette syndromePremature deathMortality riskProspective cohort studyMortality rate ratiosComorbid attention-deficit/hyperactivity disorderAttention-deficit/hyperactivity disorderExclusion of individualsCohort studyObsessive-compulsive disorderClinical significancePsychiatric disordersPaternal ageSubstance abuseSyndromeHyperactivity disorderDisordersRate ratioDeathRiskCalendar yearAgeIndividualsClinicians
2016
Prenatal and Perinatal Risk Factors and the Promise of Birth Cohort Studies: Origins of Obsessive-Compulsive Disorder
Fernandez TV, Leckman JF. Prenatal and Perinatal Risk Factors and the Promise of Birth Cohort Studies: Origins of Obsessive-Compulsive Disorder. JAMA Psychiatry 2016, 73: 1117-1118. PMID: 27706471, PMCID: PMC5180419, DOI: 10.1001/jamapsychiatry.2016.2092.Peer-Reviewed Original Research
2015
Familial Risks of Tourette Syndrome and Chronic Tic Disorders: A Population-Based Cohort Study
Mataix-Cols D, Isomura K, Pérez-Vigil A, Chang Z, Rück C, Larsson KJ, Leckman JF, Serlachius E, Larsson H, Lichtenstein P. Familial Risks of Tourette Syndrome and Chronic Tic Disorders: A Population-Based Cohort Study. JAMA Psychiatry 2015, 72: 787-793. PMID: 26083307, DOI: 10.1001/jamapsychiatry.2015.0627.Peer-Reviewed Original ResearchConceptsChronic tic disorderFirst-degree relativesTic disordersTourette syndromeFamilial riskSwedish National Patient RegisterNational Patient RegisterSecond-degree relativesRelatives of probandsPopulation-based twin sampleThird-degree relativesFamily studiesCohort studyPatient RegisterFemale patientsSpecialist clinicMAIN OUTCOMESimilar riskGeneral populationPopulation cohortHeritable neuropsychiatric conditionsNeuropsychiatric conditionsSimilar environmental exposuresEnvironmental exposuresDisordersEffect of drugs on the risk of injuries in children with attention deficit hyperactivity disorder: a prospective cohort study
Dalsgaard S, Leckman JF, Mortensen PB, Nielsen HS, Simonsen M. Effect of drugs on the risk of injuries in children with attention deficit hyperactivity disorder: a prospective cohort study. The Lancet Psychiatry 2015, 2: 702-709. PMID: 26249301, DOI: 10.1016/s2215-0366(15)00271-0.Peer-Reviewed Original ResearchConceptsAge 10 yearsAttention deficit hyperactivity disorderAge 12 yearsRisk of injuryPrevalence of injuriesCommon causeDeficit hyperactivity disorderPharmacological treatmentEmergency wardOdds ratioADHD drugsMajor public health importanceEmergency ward visitsHyperactivity disorderProspective cohort studyDanish national registersNon-treated childrenLarge disease burdenPublic health importanceEffects of drugsCohort studyWard visitsUntreated childrenAdjusted differenceDisease burdenMaternal History of Autoimmune Disease and Later Development of Tourette Syndrome in Offspring
Dalsgaard S, Waltoft BL, Leckman JF, Mortensen PB. Maternal History of Autoimmune Disease and Later Development of Tourette Syndrome in Offspring. Journal Of The American Academy Of Child & Adolescent Psychiatry 2015, 54: 495-501.e1. PMID: 26004665, DOI: 10.1016/j.jaac.2015.03.008.Peer-Reviewed Original ResearchConceptsAdjusted incidence rate ratioIncidence rate ratiosMaternal autoimmune diseaseRisk of TSAutoimmune diseasesTourette syndromeMaternal historyNational Danish health registersNationwide prospective cohort studyDanish health registersPrior autoimmune diseaseProspective cohort studyParental psychiatric diagnosisDiagnosis of TSCohort studyHealth registersPerson yearsPrior diagnosisNeuroimmunological disordersIncidence rateTS diagnosisPsychiatric diagnosisPossible associationPoisson regressionPaternal ageMortality in children, adolescents, and adults with attention deficit hyperactivity disorder: a nationwide cohort study
Dalsgaard S, Østergaard SD, Leckman JF, Mortensen PB, Pedersen MG. Mortality in children, adolescents, and adults with attention deficit hyperactivity disorder: a nationwide cohort study. The Lancet 2015, 385: 2190-2196. PMID: 25726514, DOI: 10.1016/s0140-6736(14)61684-6.Peer-Reviewed Original ResearchMeSH KeywordsAccidentsAdolescentAdultAge of OnsetAttention Deficit and Disruptive Behavior DisordersAttention Deficit Disorder with HyperactivityCase-Control StudiesCause of DeathChildChild, PreschoolConduct DisorderCross-Sectional StudiesDenmarkFemaleHumansInfantMalePoisson DistributionRisk FactorsSubstance-Related DisordersYoung AdultConceptsMortality rate ratiosAttention deficit hyperactivity disorderHighest mortality rate ratiosSubstance use disordersOppositional defiant disorderDeficit hyperactivity disorderExcess mortalityConduct disorderUse disordersMortality rateDefiant disorderHyperactivity disorderNationwide cohort studyDanish national registersCommon mental disordersExclusion of individualsCohort studyLundbeck FoundationCommon causeFamily historyCohort membersLarge cohortPsychiatric disordersUnnatural causesDanish individuals
2014
Cardiovascular Safety of Stimulants in Children with Attention-Deficit/Hyperactivity Disorder: A Nationwide Prospective Cohort Study
Dalsgaard S, Kvist AP, Leckman JF, Nielsen HS, Simonsen M. Cardiovascular Safety of Stimulants in Children with Attention-Deficit/Hyperactivity Disorder: A Nationwide Prospective Cohort Study. Journal Of Child And Adolescent Psychopharmacology 2014, 24: 302-310. PMID: 24956171, PMCID: PMC4137345, DOI: 10.1089/cap.2014.0020.Peer-Reviewed Original ResearchConceptsAttention-deficit/hyperactivity disorderProspective cohort studyCardiovascular eventsCohort studyDose-response relationshipStimulant treatmentCardiovascular safetyHazard ratioRisk factorsFirst nationwide cohort studyNationwide prospective cohort studyPossible dose-response relationshipUnique personal identification numberCardiovascular adverse eventsCardiovascular risk factorsHyperactivity disorderNationwide cohort studyNational health registersStimulant usersPopulation-based sampleAdverse eventsHealth registersProspective followCox regressionPotential confounders
2010
Predictors of early adulthood quality of life in children with obsessive–compulsive disorder
Palermo SD, Bloch MH, Craiglow B, Landeros-Weisenberger A, Dombrowski PA, Panza K, Smith ME, Peterson BS, Leckman JF. Predictors of early adulthood quality of life in children with obsessive–compulsive disorder. Social Psychiatry And Psychiatric Epidemiology 2010, 46: 291-297. PMID: 20191262, PMCID: PMC3645906, DOI: 10.1007/s00127-010-0194-2.Peer-Reviewed Original ResearchConceptsObsessive-compulsive disorderEarly adulthoodOCD symptomsImpaired Functioning ToolMethodsA longitudinal cohort studyLongitudinal cohort studyResultsForty-two percentSeverity of OCDAverage followClinical predictorsCohort studyPoor QoLResidual impairmentMild impairmentQoLSymptomsObjectivesThe goalAnxiety symptomsAdulthoodChildrenQoL.ChildhoodHoarding symptomsImpairmentDisorders
2009
Predictors of Early Adult Outcomes in Pediatric-Onset Obsessive-Compulsive Disorder
Bloch MH, Craiglow BG, Landeros-Weisenberger A, Dombrowski PA, Panza KE, Peterson BS, Leckman JF. Predictors of Early Adult Outcomes in Pediatric-Onset Obsessive-Compulsive Disorder. Pediatrics 2009, 124: 1085-1093. PMID: 19786445, PMCID: PMC3974608, DOI: 10.1542/peds.2009-0015.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAdultAge DistributionAge of OnsetChildChild, PreschoolCohort StudiesDisease ProgressionFemaleFollow-Up StudiesHumansIncidenceLongitudinal StudiesMaleMonitoring, PhysiologicMultivariate AnalysisObsessive-Compulsive DisorderPredictive Value of TestsProportional Hazards ModelsRisk FactorsSeverity of Illness IndexSex DistributionTic DisordersTime FactorsTourette SyndromeYoung AdultConceptsObsessive-compulsive disorderOCD symptomsBaseline clinical characteristicsPediatric-onset obsessive-compulsive disorderPersistent obsessive-compulsive disorderEarly adult outcomesLong-term outcomesMain outcome measuresLongitudinal cohort studyPercent of subjectsComorbid tic disordersOC symptomsHoarding symptomsAdult outcomesExperience remissionClinical characteristicsClinical predictorsCohort studyOppositional defiant disorderTic symptomsComorbid ticsEligible childrenTic disordersFemale genderOutcome measures
2006
Adulthood Outcome of Tic and Obsessive-Compulsive Symptom Severity in Children With Tourette Syndrome
Bloch MH, Peterson BS, Scahill L, Otka J, Katsovich L, Zhang H, Leckman JF. Adulthood Outcome of Tic and Obsessive-Compulsive Symptom Severity in Children With Tourette Syndrome. JAMA Pediatrics 2006, 160: 65-69. PMID: 16389213, PMCID: PMC2291298, DOI: 10.1001/archpedi.160.1.65.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAdrenergic alpha-AgonistsAdultAntipsychotic AgentsAttention Deficit Disorder with HyperactivityBipolar DisorderChildDepressive DisorderFemaleFollow-Up StudiesHumansIntelligence TestsMaleObsessive-Compulsive DisorderProspective StudiesSchizophreniaSelective Serotonin Reuptake InhibitorsSeverity of Illness IndexTic DisordersTourette SyndromeConceptsTic symptomsTourette syndromeTic severitySymptom severityObsessive-compulsive disorderBaseline clinical measurementsChildhood-onset neuropsychiatric disorderOCD symptomsPercent of patientsProspective cohort studyPercent of subjectsOutpatient specialty clinicsThird of childrenThird of adultsAge 14 yearsStructured clinical evaluationCohort studyClinical courseComplete resolutionClinical evaluationPhonic ticsSpecialty clinicFollow-up interviewObsessive-compulsive symptom severityAverage age