Metabolomics guided pathway analysis reveals link between cancer metastasis, cholesterol sulfate, and phospholipids
Johnson CH, Santidrian AF, LeBoeuf SE, Kurczy ME, Rattray NJW, Rattray Z, Warth B, Ritland M, Hoang LT, Loriot C, Higa J, Hansen JE, Felding BH, Siuzdak G. Metabolomics guided pathway analysis reveals link between cancer metastasis, cholesterol sulfate, and phospholipids. Cancer & Metabolism 2017, 5: 9. PMID: 29093815, PMCID: PMC5663111, DOI: 10.1186/s40170-017-0171-2.Peer-Reviewed Original ResearchLung metastasesMFP tumorsMammary fat pad tumorsCholesterol sulfateCancer cellsPrimary mammary fat pad tumorSpontaneous tumor metastasisMouse xenograft modelPathway analysisDistant organ sitesPrimary cancerNormal lungMouse modelXenograft modelOrgan sitesMetastasisMetastatic nicheDNA/RNA synthesisTumor cellsCancer metastasisNormal tissuesTumor metastasisTumorsDistant sitesMetabolic characteristics